With the rapid development of high-speed railways, wheel and rail wear has become increasingly serious due to the acute wheel-rail interaction. During the operation of high speed vehicle, complicated wheel-rail contact force will lead to wheel profile wear, which will worsen the dynamic performance of vehicle system, or even influence the safe operation of vehicles. In order to ensure the vehicle dynamic performance, right now regularly wheel re-profiling has to be adopted. Therefore, the study of wheel profile wear and its effect on vehicle dynamic performance is very important [1,. The purpose of the paper is to study the variation characteristics of vehicle dynamic performance with respect to the wheel profile wear through numerical simulation and field test.