To this day, Dante Alighieri’s Divine Comedy, written in the early fourteenth century, remains one of the most significant literary works of Western culture. It has not only been adapted in music, film, and art, but also in the world of video games. Since the early 1980s, video games have chosen the poetry as a basis for their plots, and various approaches to musical interpretation have emerged. With the release of Dante’s Inferno (2010), for the first time an approach was demonstrably chosen that resulted from an intensive examination of the Divine Comedy. This article explores the thesis that using literary works as a basis for video games not only affects the plot, gameplay, and character design, but also significantly influences the musical concept. Thus, it is evident that the literary source and its interpretation should be incorporated into the analysis of video game music. Thanks to Garry Schyman, who made the original scores available for analysis, the resulting musical concept will be examined more closely and compared with the previous Dante games.