Objectives: This study aims to determine the effect of spiritual leadership and work motivation on the performance of Bank BRI employees in Indonesia with job satisfaction as a moderating variable. Methods: This study uses a quantitative approach with an explanatory research design. Data collection technique is done by survey. The study population consisted of 300 BRI Bank employees spread across Indonesia. The population is infinite, so the sample size is determined based on the analytical technique. The sampling technique was purposive sampling, with the criteria of selecting respondents who were real Bank BRI employees who had worked for more than 3 months. And the analysis technique uses Smart PLS software. Results: Research result shows that spiritual leadership is the most important factor that significantly influences employee performance with a t-statistic value of 3.023 and a p-value of 0.000. This is followed by work motivation and job satisfaction which are able to moderate spiritual leadership. However, job satisfaction as a moderator was found to be unable to moderate work motivation on employee performance in this study. Implications: Based on the results of this study, leaders in their leadership regularly develop and disseminate spiritual values within the organization, especially altruistic traits that do not prioritize personal interests and show compassion for employees through attention, care, fairness, trustworthiness, respect and uphold honesty. In the end, employees feel valued and feel together as part of the workplace community, are encouraged and motivated to help each other, have faith in the meaning of work for their lives and think positively when solving problems.