Nurses, especially ICU staff, complain of high level of stress regarding the workload. This can be related to many factors such as: nurse-patient ratio, doctor’s orders, timing, hospital environment to name a few. Nursing workload can be defined as all nursing work that must be carried out over a defined period of time. For example the effect of workload on covid-19 patients in intensive care units (ICUs) showed that higher RN staffing was associated with lower levels of hospital related mortality. Each additional full time equivalent RN per patient day corresponds to a 9% reduction in odds of death in ICUs. The aim of this study was to determine the extent of the effect of workload on nurses and other associated factors. A descriptive cross-sectional study was conducted in July to September 2020. 406 staff nurses were enrolled in the study. Instrument of the study was a questionnaire on the effect of workload on nursing staff who were taking care of covid-19 patients. Multiple logistic regression was utilized to identify the factors associated with high nursing workload of nurses. By using bivariate analysis; workload was found to be significantly associated with: nurse patient ratio, duty hours and type of department; the critical care units such as ICU, CCU and HD complained of higher workload (28.8, SD 3.7) than general units (20.7, SD 3.0) the P-value was 0.033. There was no significant difference between the workload and other demographic variables such as: environmental status, nationality, and type of hospital.