The hospital provides services in inpatient, outpatient and emergency departments. The increase in the number of hospitals every year from 2016 amounted to 2046, expanding in 2021 to a total of 2514 public hospitals in Indonesia. (Statistics Center data for 2016-2021). This shows that the level of hospital competition is getting tighter, so the demands for hospitals to improve nurse performance are getting higher. Work performance can be affected by several things, including stress and workload based; research in local Indian hospitals showed 34% of nurses experienced moderate stress, and as many as 2% experienced high stress, to cause physical and mental health problems; another study involving nurse subjects at Makassar hospital also showed nurses who experienced stress and felt a heavy workload until work performance decreased by 91.7%. This study aims to see the relationship and significant influence between work stress and nurse workload on nurses' work performance. The research method is a cross-sectional analytical study and a method of research sampling with total sampling techniques. The results of univariate studies showed that most subjects were female, 65.7%, age range 26-30 years, high level of work stress (53.9%), and moderate workload (76.3%). The bivariate results in this study showed a relationship between nurses' work stress and workload (p value 0.024). Research shows no workload relationship to work performance (p value 0.84). The results of multivariate analysis with logistic regression showed that the variable work stress was associated with p value 0.011, with high stress having 11,014 times and low stress 3.522 against low work performance. The conclusion of the study can be seen in the relationship of work performance variables to stress, and high stress causes nurses to have a risk of 11,014 times experiencing low work performance.