<i>Introduction</i>: The widespread adoption of mobile health (mHealth) technology has become a crucial aspect of healthcare delivery, particularly in regions with limited access to traditional healthcare systems. Cameroon, a Central African nation grappling with a high prevalence of HIV/AIDS, presents a suitable context for mHealth interventions. This study aims to assess expert opinions on the application of mHealth for data services in implementing HIV programs in Cameroon. <i>Methods</i>: Employing a mixed-methods approach, we utilized a quantitative cross-sectional design (via a survey questionnaire) and a qualitative design (through in-depth interviews). The purposive sample technique was employed to recruit health specialists from diverse organizations and healthcare facilities across the country. <i>Results</i>: Analysis of responses from mHealth experts revealed that 76% held a positive perspective on using mHealth for data services in HIV program implementation in Cameroon, while 24% expressed a negative opinion. Statistical analysis did not reveal a significant association (p = 0.265) between qualifications and perspectives on mHealth. Monitoring and Evaluation (M&E) experts exhibited a notable association (94.1%) with positive perspectives on mHealth utilization. In contrast, IT specialists and public health experts demonstrated slightly lower percentages (78.6% and 60%, respectively). <i>Conclusion</i>: Experts in mHealth conveyed optimism about using mHealth to provide data services for implementing HIV programs in Cameroon. The study discovered that mHealth users' perceptions were positively correlated with age group and work position. However, there was no discernible relationship between the attitudes of mHealth users and gender or educational attainment.
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