Working Memory Research Articles

Working memory gating in obesity is moderated by striatal dopaminergic gene variants

Everyday life requires an adaptive balance between distraction-resistant maintenance of information and the flexibility to update this information when needed. These opposing mechanisms are proposed to be balanced through a working memory gating mechanism. Prior research indicates that obesity may elevate the risk of working memory deficits, yet the underlying mechanisms remain elusive. Dopaminergic alterations have emerged as a potential mediator. However, current models suggest these alterations should only shift the balance in working memory tasks, not produce overall deficits. The empirical support for this notion is currently lacking, however. To address this gap, we pooled data from three studies (N = 320) where participants performed a working memory gating task. Higher BMI was associated with overall poorer working memory, irrespective of whether there was a need to maintain or update information. However, when participants, in addition to BMI level, were categorized based on certain putative dopamine-signaling characteristics (single-nucleotide polymorphisms [SNPs]; specifically, Taq1A and DARPP-32), distinct working memory gating effects emerged. These SNPs, primarily associated with striatal dopamine transmission, appear to be linked with differences in updating, specifically, among high-BMI individuals. Moreover, blood amino acid ratio, which indicates central dopamine synthesis capacity, combined with BMI shifted the balance between distractor-resistant maintenance and updating. These findings suggest that both dopamine-dependent and dopamine-independent cognitive effects exist in obesity. Understanding these effects is crucial if we aim to modify maladaptive cognitive profiles in individuals with obesity.

Adversity and working memory: Nuanced effects underpinned by rigorous methodology

Adversity and working memory: Nuanced effects underpinned by rigorous methodology

Effects of open-skill and closed-skill exercise on subthreshold depression in female adolescents: A randomized controlled trial

BackgroundSubthreshold depression (SD) affects a significant proportion of adolescent females, posing a risk of major depression in later life. This study examines the effects of open-skill exercise (OSE) and closed-skill exercise (CSE) on SD, executive function (EF), and emotional states in female adolescents. MethodsA double-blind randomized controlled trial involved 95 female adolescents (mean age = 16.73 ± 0.42 years) with SD symptoms. Participants were assigned to OSE, CSE, or control (CON) groups and underwent an 8-week exercise program. Primary outcomes were assessed using the Beck Depression Inventory (BDI-13) and the Center for Epidemiological Studies Depression Scale (CES-D), with secondary outcomes including EF tasks and emotional assessments. Differences were examined using generalized linear mixed models with intention-to-treat and multiple imputation. ResultsBoth OSE and CSE significantly reduced depressive symptoms, with CSE showing greater improvement. EF assessments showed enhanced cognitive flexibility and working memory in both exercise groups at 4 weeks, and superior inhibitory control and cognitive flexibility in the CSE group at 8 weeks. Emotional assessments indicated a notable reduction in negative emotions in the CSE group after 8 weeks. ConclusionsBoth OSE and CSE reduce SD symptoms in female adolescents, with CSE providing more sustained benefits for EF and emotional states. Further research on exercise interventions for mental health is warranted.Trial registration number: ChiCTR2400081139

Distractor filtering and task load in working memory training in healthy older adults.

Filtering efficiency (FE) has been suggested as a task-related process of working memory (WM) in older adults, but the interaction of distractors with WM when implemented as a training to improve WM capacity is unclear. To investigate the effect of manipulations of WM and/or FE load in a multicomponent model-based WM training in improving WM capacity. 205 healthy older adults (129 women; aged 64.0 ± 8.3 years) were randomised into three WM training groups with manipulations of WM and FE load (high WM; low FE load, high WM; high FE load and low WM; high FE load). All groups underwent three online cognitive testing sessions and twelve 40-min training sessions over three weeks using the SmartBrain smartphone application. WM capacity was measured with complex span tasks and FE using the Change Detection Task. Linear mixed-effect models adjusted for age, sex, education and pre-baseline performance showed increased WM capacity post-training, but no difference between groups. While both distractors and WM are needed to improve WM in the absence of distraction, manipulations of the FE and WM load do not influence improvements following training.

Cognitive Health Benefits of Everyday Physical Activity in a Diverse Sample of Middle-Aged Adults.

Physical activity has been associated with a wide range of health benefits including long-term benefits for cognitive and brain health. Whether episodes of everyday physical activity are associated with immediate cognitive benefits remains unknown. The purpose of the current study was to examine whether episodes of physical activity, occurring over the course of participants' daily lives, are associated with short-term improvements in cognitive health. Participants completed a 9-day ecological momentary assessment protocol involving 5 daily assessments of self-reported physical activity and ambulatory cognitive assessments of processing speed and visuospatial working memory. Data were analyzed in a multilevel modeling framework to explore changes in performance on each task associated with physical activity during the period leading up to the assessment as well as individual differences in average frequency of physical activity. Results of MLMs indicated that engaging in physical activity during the period (~3.5hr) leading up to an assessment was associated with improvements in processing speed equivalent to 4 years of cognitive aging. Such improvements were observed for both light and moderate-to-vigorous physical activity levels. No association was observed for visuospatial working memory accuracy; however, response time during the working memory task reliably mirrored the association observed for processing speed. The short-term benefits were observed, particularly, for individuals with an overall higher frequency of reported physical activity. Our findings suggest that engaging in everyday physical activity of any intensity level may have short-term, acute benefits for cognitive health and point to new potential targets for intervention. NCT03240406.

Improving cognitive function in Chinese children with ADHD and/or RD through computerized working memory training

BackgroundPrior research has found that children with attention-deficit hyperactivity disorder (ADHD) and reading difficulties (RD) are at an elevated risk of developing further cognitive deficits and developmental challenges [1]. ADHD and RD are characterized by a deficit in working memory, which negatively affects learning and behavior. The main aims of this study were to design a working memory training app and examine its effectiveness through a 5-week training program in Chinese children with ADHD and/or RD.MethodsThere were three experimental groups, with 26 participants in the ADHD group, 38 participants in the RD group, and 24 participants in the ADHD + RD group. The typically developing (TD) control group had 32 participants. All participants completed the pretest and posttest assessments on executive function and reading performance.ResultsThe findings indicate that the experimental groups improved performance in verbal and visual-spatial working memory as well as Chinese word reading. There was an overall reduction in functional impairment following the training, in contrast to the TD group.ConclusionThis study showed that working memory can be improved through computerized training in children with ADHD and/or RD. The implications of future research in working memory are discussed.Trial registrationClinical Trials Identifier: NCT06567444 (retrospectively registered) on 20 August 2024.

Exploring Working Memory in Context Sensitivity

ABSTRACT Context sensitivity refers to the ability to identify cues regarding the nature of stressor situations. This skill is a necessary precursor to successful emotion regulation and may involve detecting the presence or absence of stressor cues. Previous research has suggested that context sensitivity relies in part on working memory (WM), one component of cognitive control or executive functioning. We explored this potential relationship in an empirical study (N = 112) that assessed WM via WAIS-IV Digit Span as well as the ability to detect the presence or absence of stressor cues via the Context Sensitivity Index. Results demonstrated that detection of both cue presence and absence were significantly associated with the ability to apply semantic knowledge to information held in WM. Our findings expand upon a potential cognitive mechanism for context sensitivity.

Voice biomarkers in middle and later adulthood as predictors of cognitive changes.

Prosody voice measures, especially jitter and shimmer, have been associated with cognitive impairment and hold potential as early indicators of risk for cognitive decline. Prior research suggests that voice measures assessed concurrently with longitudinal cognitive outcomes are associated with 10-year cognitive declines in middle-age and older adults from Midlife in the U.S. (MIDUS) study. Using a subsample from the same study, we expanded previous research to examine voice measures that were (1) collected 8 years before cognitive outcomes, (2) derived from narrative speech in logical memory tests instead of word list recall tests, and (3) independent of the cognitive outcomes. Multilevel analyses controlled for covariates of age, sex, education, neurological conditions, depressive symptoms, and chronic conditions. The results indicated that higher jitter and lower shimmer predicted greater 10-year declines in episodic memory and working memory. These findings extend previous research by highlighting prosody voice measures assessed 8 years earlier as predictors of subsequent cognitive declines over a decade.

The Suppression Mechanisms of Passive Memory in Visual Working Memory: The Evidence from Electrophysiology.

Recent studies of visual working memory (VWM) underscore a structured hierarchy of storage states. Memories that are not immediately relevant to the task at hand but are essential for later use are transferred to a passive state, which operates independently of actively maintaining and manipulating current memories. Note that stimulating passive memory forcefully can reactivate it into an active state, resulting in a competition with active memory. Thus, to remain stable representations for both states within VWM, passive memory might involve sustained suppression during activity-silent maintenance to prevent reactivation from disrupting the current active storage. To investigate this, we analyzed lateralized electrophysiology signals while human participants (both women and men) were engaged in a sequential presentation memory task across two experiments. The results revealed positive contralateral delayed activity components and lateralized alpha enhancement for passive memory, neural indicative of suppression on passive storage. In addition, the suppression effect was independent of the memory load in both the active and the passive states. These findings support the notion of sustained suppression during activity-silent maintenance of passive memory, facilitating the stable maintenance of distinct storage states and advancing our understanding of the dynamic coding framework in VWM.

Distinct functions for beta and alpha bursts in gating of human working memory

Multiple neural mechanisms underlying gating to working memory have been proposed with divergent results obtained in human and animal studies. Previous findings from non-human primates suggest prefrontal beta frequency bursts as a correlate of transient inhibition during selective encoding. Human studies instead suggest a similar role for sensory alpha power fluctuations. To cast light on these discrepancies we employed a sequential working memory task with distractors for human participants. In particular, we examined their whole-brain electrophysiological activity in both alpha and beta bands with the same single-trial burst analysis earlier performed on non-human primates. Our results reconcile earlier findings by demonstrating that both alpha and beta bursts in humans correlate with the filtering and control of memory items, but with region and task-specific differences between the two rhythms. Occipital beta burst patterns were selectively modulated during the transition from sensory processing to memory retention whereas prefrontal and parietal beta bursts tracked sequence order and were proactively upregulated prior to upcoming target encoding. Occipital alpha bursts instead increased during the actual presentation of unwanted sensory stimuli. Source reconstruction additionally suggested the involvement of striatal and thalamic alpha and beta. Thus, specific whole-brain burst patterns correlate with different aspects of working memory control.

Relationship Between Socioeconomic Status and Basic Auditory Processing in Young Adults.

The current study aimed at investigating the relationship between socioeconomic status (SES) and basic auditory processing in young adults with normal hearing. Specifically, we sought to determine whether SES metrics, including parental education, parental occupation, and individual education attainment, influenced performance on tasks of basic auditory processing. Secondarily, we also aimed at understanding the interactive effects of SES and working memory on basic auditory processing. A total of 38 young adults were included in the study. Self-reported SES measures were recorded through Likert scales, and auditory processing measures included tests for temporal fine structure (TFS) and spectrotemporal sensitivity (STS). Pearson correlation analyses were conducted to probe the relationships between SES indicators and auditory processing performance. Multiple linear regressions were conducted to understand the interactive effects of SES and working memory on auditory processing performance. The analysis revealed no significant correlation between SES measures and basic auditory processing performance across TFS and STS tasks. Furthermore, analysis investigating the interaction between SES and working memory also yielded nonsignificant results. These findings indicate that, within this specific age cohort, SES information may not be indispensable for assessing basic auditory processing. Our study suggests that SES may not significantly influence basic auditory processing in young adults with normal hearing. However, further research with larger sample sizes and longitudinal designs is warranted to confirm these findings and explore potential age-related differences in the impact of SES on auditory processing across the lifespan.

Maternal trauma exposure is linked to adult offspring's cognitive functioning in the context of mass violence.

This study aimed to examine whether mothers' level of trauma exposure and posttraumatic stress disorder (PTSD) symptoms are related to their offspring's cognitive functioning. Mothers exposed to the 1994 genocide perpetrated against the Tutsi (N = 181) and one of their adult offspring were recruited in Rwanda. Mothers and their offspring answered questionnaires on sociodemographic information, the level of trauma exposure, and PTSD symptoms. They also performed a backward digit span task and a similarity task to assess their working memory and abstract reasoning, respectively. Hierarchical regression models were used to analyze the data. Mothers' level of trauma exposure, but not PTSD symptoms, was significantly related to their offspring's abstract reasoning performance after controlling for offspring's age, sex, and economic status. The relationship between mothers' level of trauma exposure, PTSD symptoms, and their offspring's working memory performance was not significant. Offspring's education was significantly linked to their working memory and abstract reasoning performance. The findings demonstrate that the intergenerational transmission of trauma can impact the cognitive functioning of the next generation. These results also illustrate the profound and long-term human impact of mass violence. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Le rôle de la mémoire de travail dans l’acquisition incidente du vocabulaire en langue seconde durant la compréhension orale chez les enfants : une revue de littérature

Developing vocabulary to understand oral and written language in first language (L1) and second language (L2) is a major challenge for both adults and young learners. The learning of words also depends on the working memory (WM), which is central to human cognition and language learning; several studies have established its important role in learning L1 (Gathercole & Baddeley, 1989, 1990) and, even more so, in L2 (Baddeley & al., 1998; Gathercole & al., 1999; Service & Kohonen, 1995). Despite previous studies on the role of WM in the incidental acquisition of second language vocabulary during listening comprehension, the need for clarification on this role, especially in children, remains to be explored. The aim of this article is to present a synthesis of the literature on the role of WM in the incidental acquisition of second language vocabulary during listening comprehension in children to highlight this need for the necessary clarifications.

Susceptibility to Attentional Capture by Target-Matching Distractors Predicts High Visual Working Memory Capacity

Recent event-related potential (ERP) studies showed that individuals with low visual working memory (VWM) capacity are more susceptible to salience-driven attentional capture than high-capacity individuals are, with the latter being able to proactively suppress salient but irrelevant distractors. However, it remains unclear whether and how contingent attentional capture by distractors that possess a task-relevant (target) feature is related to VWM capacity. Here, we adopted a central focused-attention task that contained peripheral target-matching distractors to investigate this issue (N = 51 adults). Surprisingly, we revealed that target-matching distractors elicited both a larger N2-posterior-contralateral (N2pc) and a larger post-N2pc distractor positivity (PD) component in high-capacity individuals than in low-capacity ones, meaning that high-capacity individuals are less able to ignore such distractors initially, though they could call on a stronger reactive suppression mechanism afterward. These findings illustrate that high-capacity individuals are more (rather than less or equally) susceptible to contingent attention capture compared with low-capacity ones.

Active maintenance of working memory contents affects functioning of attentional filtering.

Salient objects are well known to capture attention. Furthermore, a stimulus associated with the attention-capturing objects could infiltrate into working memory. This was recently formulated as filter disruption theory. In the present study, we asked whether such disruption of filter and incidental encoding of irrelevant information into working memory could be prevented. We hypothesized that an active maintenance of information could activate top-down control, thereby preventing the incidental infiltration of irrelevant information into working memory. In experiments, participants performed two consecutive visual searches while maintaining a visual item in working memory. In the first search, one of nontarget items was associated with a salient distractor. Importantly, the color of the nontarget item related to the salient distractor was incidentally encoded into working memory, exerting memory-driven attentional capture in the second search. However, such incidental encoding of irrelevant information into working memory did not occur when participants had to maintain a single color in working memory. This provides novel evidence that while the attentional filter is subject to perceptual distraction, active maintenance of information in working memory can prevent such disruption of the filter.

Theta-gamma-coupling as predictor of working memory performance in young and elderly healthy people

The relationship between working memory (WM) and neuronal oscillations can be studied in detail using brain stimulation techniques, which provide a method for modulating these oscillations and thus influencing WM. The endogenous coupling between the amplitude of gamma oscillations and the phase of theta oscillations is crucial for cognitive control. Theta/gamma peak-coupled transcranial alternating current stimulation (TGCp-tACS) can modulate this coupling and thus influence WM performance. This study investigated the effects of TGCp-tACS on WM in older adults and compared their responses with those of younger participants from our previous work who underwent the same experimental design. Twenty-eight older subjects underwent both TGCp-tACS and sham stimulation sessions at least 72 h apart. Resting-state electroencephalography (EEG) was recorded before and after the interventions, and a WM task battery with five different WM tasks was performed during the interventions to assess various WM components. Outcomes measured included WM task performance (e.g., accuracy, reaction time (RT)) and changes in power spectral density (PSD) in different frequency bands. TGCp-tACS significantly decreased accuracy and RT on the 10- and 14-point Sternberg tasks and increased RT on the Digit Symbol Substitution Test in older adults. In contrast, younger participants showed a significant increase in accuracy only on the 14-item Sternberg task. Electrophysiological analysis revealed a decrease in delta and theta PSD and an increase in high gamma PSD in both younger and older participants after verum stimulation. In conclusion, theta-gamma coupling is essential for WM and modulation of this coupling affects WM performance. The effects of TGCp-tACS on WM vary with age due to natural brain changes. To better support older adults, the study suggests several strategies to improve cognitive function, including: Adjusting stimulation parameters, applying stimulation to two sites, conducting multiple sessions, and using brain imaging techniques for precise targeting.

Working memory as a predictor of reading and listening comprehension in EFL college students: A reinvestigation

This study re-examines the role of working memory in aural/oral comprehension among English as a Foreign Language (EFL) college students, building upon previous research (Aldosari & Mekheimer, 2018). The investigation aims to determine the predictive relationship between working memory span and both reading and listening comprehension skills, with a particular focus on understanding whether specific working memory components contribute differentially to comprehension abilities. A sample of 100 female and 100 male EFL college students participated. Participants were administered working memory tasks, including the WRMT-III Passage Comp. subtest, followed by standardized reading and listening comprehension tests (WIAT II). Hierarchical regression analyses revealed that the WRMT-III Passage Comp. subtest was a powerful predictor of both reading and listening comprehension, consistently across genders. This subtest made a significant unique contribution to predicting comprehension skills even when controlling for other working memory components. T-tests revealed no significant differences in comprehension scores between male and female participants. The study highlights the crucial role of working memory in EFL college students' aural/oral comprehension and underscores the potential of the WRMT-III Passage Comp. subtest as a valuable tool for assessing working memory skills relevant to language learning. Further research examining the influence of individual working memory components on specific comprehension skills is recommended.

Vocabulary Acquisition in Beginner L2 Learners

This project focuses on how different vocabulary teaching methods may develop efficient lexical-semantic networks in L2 learners. Vocabulary that frequently co-occurs in the environment becomes associated in the lexicon (e.g., food + sports) and it strengthens the representation of vocabulary. This experiment tests the effect of co-occurrence presentation and thematic list presentation on vocabulary processing. The goal is to inform vocabulary teaching methods. L2 learners completed a pre-test, four sessions of vocabulary training, and an immediate post-test. During training sessions, participants saw images on a computer and reviewed Spanish vocabulary, under one of two conditions: one word presented at a time in thematic lists (e.g., food), or words displayed in a visual scene or context (e.g., dinner party). During testing, participants completed a picture naming task to assess how different types of vocabulary exposure impacts L2 processing. Other individual differences such as working memory and proficiency were collected as well. The results from the picture naming task show that effectiveness of training in thematic list (TL) verse visual scene (VS) depended on initial proficiency and working memory. Participants with a higher initial proficiency and working memory improved more when trained with the VS condition, while those with lower proficiency and working memory had greater success when trained via the TL condition.

Predictors of sentence recall performance in children with and without DLD: Complexity matters.

Using archival data from 106 children with and without DLD who spoke two dialects of English, we examined the independent contributions of vocabulary, morphological ability, phonological short term memory (pSTM), and verbal working memory (WM) to exact sentence recall, ungrammatical repetition, and incorrect tense production. For exact repetitions on simpler sentences, performance of the DLD group was predicted by morphological ability, pSTM and WM, while that of the TD group was predicted by vocabulary and sometimes pSTM. On complex sentences, performance of the DLD group was predicted by morphological ability, and the TD group was predicted by pSTM and WM. For ungrammatical repetitions and incorrect tense, morphological ability was a factor for both groups, with WM also affecting the DLD group for ungrammatical production. Thus, sentence recall taxes multiple resources, with more and different factors being taxed at lower levels of complexity for children with DLD than those without.

Executive functions in older adults with generalised anxiety disorder and healthy controls: Associations with heart rate variability, brain-derived neurotrophic factor, and physical fitness

Executive functions (EF) decline with age and this decline in older adults with generalised anxiety disorder (GAD) may be influenced by heart rate variability (HRV), brain-derived neurotrophic factor (BDNF), and physical fitness. Understanding these relationships is important for tailored treatments in this population. In this study, 51 adults with GAD (M age = 66.46, SD = 4.08) and 51 healthy controls (M age = 67.67, SD = 4.04) were assessed on cognitive inhibition (Stroop task), shifting (Trails part 4), flexibility (Wisconsin Card Sorting Test – Perseverative errors), working memory (Digit Span Backwards), IQ (Wechsler Abbreviated Scale of Intelligence), high frequency HRV, serum mature BDNF levels, and VO2 max. Results indicated that participants with GAD exhibited better cognitive inhibition compared to controls, with no general reduction in EF. Cognitive inhibition was predicted by gender, HRV, and BDNF levels, while cognitive shifting was predicted by gender and IQ, and cognitive flexibility and working memory by IQ. The enhanced cognitive inhibition in GAD participants might stem from maladaptive use of this function, characteristic of GAD, or protection from EF decline due to normal HRV. Increased BDNF levels, possibly due to good fitness, or compensatory mechanisms related to the disorder, might also play a role. These findings highlight the complexity of EF and related mechanisms in GAD, highlighting the need for interventions that consider both cognitive and physiological factors for optimal outcomes.