Background: Nurses make up the largest percentage of health workers and play an important role in providing health services, so nurses are at high risk of fatigue. Fatigue can cause nurses to make mistakes in work procedures so that it will have a negative impact on patients. This study aims to analyze the risk factors of nurses' work fatigue in the Inpatient Room of Hospital X and Hospital Y in Kendari City, Southeast Sulawesi Province, Indonesia. Methods: The type of research used is analytic which is observational using cross sectional research design with univariate, bivariate and multivariate tests. The population in this study were all nurses in the Inpatient Room of Hospital X and Hospital Y with sampling techniques using total sampling so that the sample amounted to 131 nurses. Data analysis using chi-square test and logistic regression. Results: The results showed that there was an effect of work stress (0.00), workload (0.04), work shift (0.00), tenure (0.00) on nurses' work fatigue in the Inpatient Room of Hospital X and Hospital Y and there was no effect of length of service (0.69) on nurses' work fatigue in the Inpatient Room of Hospital X and Hospital Y. Conclusion: The conclusion of this study is that there is an effect of work stress, workload, work shifts and tenure on job fatigue in nurses. Work stress variable is the most influential variable on nurses' work fatigue with an Exp(B) value of 14.647.
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