The purpose of this study was to determine if chronic LBP and chronic neck pain-associated fatigue responded to multidisciplinary multimodal treatment not specifically targeted to the treatment of fatigue. A total of 85 chronic LBP and 33 chronic neck pain patients completed the Multidimensional Fatigue Inventory (MFI), Neuropathic Pain Scale (NPS), and Beck Depression Inventory on admission. In addition, an information tool was completed on each CPP. This tool listed demographic information, primary and secondary pain diagnoses, DSM-IV psychiatric diagnoses assigned, pain location, pain precipitating event, type of injury, years in pain, number of surgeries, type of surgery, type of pain pattern, opioids consumed per day in morphine equivalents, worker compensation status, and whether according to the clinical examination, the CPP did or did not have a neuropathic pain component. At completion of the multidisciplinary multimodal treatment, each CPP again completed the MFI. Student T-test was utilized to test for statistical changes on the MFI five scales pre to post treatment. Pearson and point biserial correlations were utilized to determine which variables significantly correlated with MFI change scores. Variables found significant at less or equal to 0.01 were utilized in a stepwise regression analysis to find variables predictive of change in MFI scores. Multidisciplinary multimodal treatment significantly improved CPP fatigue as measured by the MFI. The available variables utilized to predict improvement in fatigue explained only a small percentage (28.9%) of the variance. Improvement in fatigue was predicted by NPS-10 scale scores (neuropathic pain). Multidisciplinary multimodal pain facility treatment improves chronic LBP and neck pain associated fatigue. Improvement could not be predicted with significant accuracy. The purpose of this study was to determine if chronic LBP and chronic neck pain-associated fatigue responded to multidisciplinary multimodal treatment not specifically targeted to the treatment of fatigue. A total of 85 chronic LBP and 33 chronic neck pain patients completed the Multidimensional Fatigue Inventory (MFI), Neuropathic Pain Scale (NPS), and Beck Depression Inventory on admission. In addition, an information tool was completed on each CPP. This tool listed demographic information, primary and secondary pain diagnoses, DSM-IV psychiatric diagnoses assigned, pain location, pain precipitating event, type of injury, years in pain, number of surgeries, type of surgery, type of pain pattern, opioids consumed per day in morphine equivalents, worker compensation status, and whether according to the clinical examination, the CPP did or did not have a neuropathic pain component. At completion of the multidisciplinary multimodal treatment, each CPP again completed the MFI. Student T-test was utilized to test for statistical changes on the MFI five scales pre to post treatment. Pearson and point biserial correlations were utilized to determine which variables significantly correlated with MFI change scores. Variables found significant at less or equal to 0.01 were utilized in a stepwise regression analysis to find variables predictive of change in MFI scores. Multidisciplinary multimodal treatment significantly improved CPP fatigue as measured by the MFI. The available variables utilized to predict improvement in fatigue explained only a small percentage (28.9%) of the variance. Improvement in fatigue was predicted by NPS-10 scale scores (neuropathic pain). Multidisciplinary multimodal pain facility treatment improves chronic LBP and neck pain associated fatigue. Improvement could not be predicted with significant accuracy.