It was accounted for ABI as damage to the brain which brings about disintegration in subjective, physical, enthusiastic and autonomous working. Acquired brain injury can occur due to injury, hypoxia, contamination,tumor, substance manhandle, degenerative neurological sickness and stroke1,2. Serious ABI is characterized as a GCS of 3-8 after cardiopulmonary revival in a patient with an irregular computer tomography (CT) output of the head which shows haematomas, wounds, oedema, and compacted basal cisterns3,4. The definitions gave in this passage were embraced for use in this ABI investigation.CPIS was used to diagnose and determine the incidence of VAP. Clinicalpulmonaryinfectionscore(CPIS)- Temperature(ºC) ≥36.5and≤38.4=0point ≥38.5and≤38.9=1point ≥39or≤36=2points Bloodleukocytecount(cells/mm3) ≥4,000and≤11,000=0point <4,000or>11,000=1point+bandforms ≥500=+1point Trachealsecretions Scanty=0point Moderate/profusebutnotpurulent=1point Moderate/profuseandpurulent=2point Oxygenation:PaO2/FiO2 >240orARDS=0point ≤240andnoevidenceofARDS=2points Pulmonaryradiography Noinfiltrate=0point Patchy/diffuseinfiltrates=1point Localisedinfiltrate=2points Culture of tracheal aspirate (semi-quantitative) Pathogenic bacteria cultured ≤ 1+ or nogrowth=0point Pathogenicbacteriacultured>1+ornogrowth=1point SamepathogenicbacteriaseenonGramstain>1+=2points Totalscore=CPIS(possiblerange=0to12) Methods: Respiratory physiotherapy procedures assists to expand lung volumes, enhance gas diffusion,reduce work of breathing, reduce MV stay of patients and induce optimum recovery.Inthis the respiratory physiotherapy applications involved a regimen of Positioning, Manual Hyperinflation (MH), Airway Suctioning,PNF for Respiration, Passive Limb Movement protocol and Early Mobilisation protocol. Results: The results shows that the Chronic Pulmonary Infection Score (CPIS) reduced from at the time of admission to at the time of discharge, the significance of P<.005 Conclusion: Respiratory physiotherapy managed Chronic Pulmonary Infection Score (CPIS) reduction from at the time of admission to at the time of discharge and improved the outcome of the ABI patients.