Clinical Research Work Research Articles

ERPDB: An Integrated Database of ERP Data for Neuroinformatics Research

Event-related potential (ERP) is the measurement of the brain's electrical activity in response to different types of events, such as attention, words, thinking, or sounds. By measuring the brain's response to such events, we can learn how different types of information are processed. As the mass of recorded ERP data explodes, an automatic and accurate tool to store, manage, and retrieve data readily is of increasing concern in neuroinformatics. In this paper, we describe a relational ERP database that has been constructed using the SQL server 2000 database management system and an IIS web server that has been setup for data retrieval through a custom web interface (http://202.113.232.103:8088/erpdb/index.asp). A novel database structure has been used to store ERP data of different activity channels, which provides a rapid and accurate way for data retrieval within any given range on the time zone with various searching options. The database is divided into: (1) subjects' information and record information and (2) ERP data, which has been structured and standardized in a database table supplemented with unrestricted text files. It can integrate or exchange data with other clinical databases or computer-based information systems through a program based on ADO techniques. Users are able to readily retrieve ERP data through the user-friendly web page interface. All online resources of the database are freely available to the scientific community. As the database develops further, we anticipate it will become a valuable tool that will make a great contribution to everyday clinical practice, teaching, and research work inneuroscience and psychology in the future.

Reduced‐intensity conditioning allogeneic stem cell transplantation for patients with chemoresistant or relapsed follicular lymphoma

Patients with recurrent advanced stage follicular lymphoma (FL) have a poor prognosis (median survival 4–5 years) with limited therapeutic options. Conventional allogeneic stem cell transplantation (allo-SCT) was suggested to be a curative option for FL. However, the benefit of standard myeloablative allo-SCT is usually offset by high transplant-related mortality (TRM) (Peniket et al, 2003). Reduced-intensity conditioning (RIC) allo-SCT generated some interesting results in patients with FL and were related to a potent graft-versus-lymphoma (GVL) effect (Khouri et al, 2001; Marks et al, 2002; Faulkner et al, 2004). Here, we report our experience in eight FL patients who received RIC allo-SCT in progressive and/or chemoresistant disease. All donors were human leucocyte antigen (HLA)-identical siblings. Details of the patients’ characteristics, transplant procedures, graft-versus-host disease (GVHD) features and outcome are summarised in Table I. Of note, four patients had relapsed after autologous SCT (ASCT) and three had chemoresistant disease at the time of allo-SCT. After RIC allo-SCT, sustained engraftment of neutrophils and platelets was achieved in all patients. With a median follow-up of 19 (range, 7–85) months, the cumulative incidence of TRM was 25% (95% confidence interval, 3–65%, Patients 2 and 3). These two patients died of chronic GVHD (cGVHD), and were in complete remission (CR) at time of death. The cumulative incidence of grade 2 to 4 acute GVHD (aGVHD) was 62% (five patients), and seven out of eight patients (87%) developed cGVHD (six extensive and one limited). Objective disease responses were observed concomitantly or after GVHD onset, without any additional chemotherapy. Interestingly, of the three patients who were chemoresistant at the time of allo-SCT (Patients 2, 5 and 6), two experienced CR after grade 2 aGVHD (Patients 2 and 6). One of them is still in CR 19 months after allo-SCT (Patient 6), whereas the other died in CR at 7 months from cGVHD (Patient 2). One patient experienced disease recurrence at 8 months, after ciclosporin A taper, and received a donor lymphocyte infusion (DLI) at 10 months, which induced CR (Patient 8). In two other patients, disease progressions occurred after allo-SCT (Patients 1 and 5), at 8 and 42 months, but both are still alive after salvage chemotherapy. Patient 5 was allografted in chemoresistant progressive disease and did not experience GVHD, neither after immunosuppression withdrawal, nor after DLI. Interestingly, Patient 1 responded to salvage ESHAP (etoposide, methylprednisolone, cytarabine, cisplatin)-type chemotherapy combined with radiotherapy at 42 months, and achieved a sustainable CR (though this patient had previously failed ASCT). Eighty-five months later, this patient is still alive in CR. Patients with chemoresistant FL or who failed ASCT have limited therapeutic options. Because of its potential to reduce TRM, RIC allo-SCT has arisen as an attractive modality in patients with FL. However, the role of RIC allo-SCT in this disease remains a matter of debate (Bierman et al, 2003). In the myeloablative setting, allo-SCT failed to demonstrate superior survival when compared with purged ASCT, and neither acute nor cGVHD appeared to significantly reduce the relapse risk (van Besien et al, 2003). In this study, a potent GVL effect can be suggested, as six patients experienced an objective response concomitantly to GVHD, or after DLI. In contrast, one patient did not develop signs of GVHD, and relapsed shortly after allo-SCT. The alkylating agent (busulfan) contained in the RIC regimen is unlikely to explain disease control, because the majority of patients had failed multiple chemotherapy regimens including ASCT with high-dose alkylating agents. Despite its obvious limitations, mainly due to its small size, this study indicated that RIC allo-SCT is feasible and may be a therapeutic option for those patients with chemoresistant disease and/or who have relapsed after ASCT, as a significant GVL effect can be achieved in this particular population. We thank the ‘Association pour la Recherche sur le Cancer (ARC; ARECA Pole)’, the ‘Ligue Nationale contre le Cancer’, the ‘Fondation de France’, the ‘Fondation contre la Leucémie’, the ‘Agence de Biomédecine’, the ‘Association Cent pour Sang la Vie’, and the ‘Association Laurette Fuguain’ for their generous and continuous support for our clinical and basic research work. Our group is supported by several grants from the French ministry of health as part of the ‘Programme Hospitalier de Recherche Clinique (PHRC)’.

Phototherapy and malignancy: Possible enhancement by iron administration and hyperbaric oxygen

Photodynamic therapy (PDT) is a new therapeutic approach for the treatment of malignant tumors. Hyperbaric oxygen (HBO(2)) shows beneficial effects in various modalities of cancer interventions. Tumor cells tend to accumulate large amount of iron. There is interaction between tissue content of oxygen, iron, free radical production and tissue damage. Accumulation of intracellular iron is necessary for the production of oxygen radicals. HBO(2) increases tissue oxygen and hydrogen peroxide production in the cells. Malignant cells require iron, and exhibit more transferrin receptors. The photodynamic sensitization of human leukemic cells is achieved with accumulation of porphyrins stimulated by 5-aminolaevulanic acid (ALA) plus hemin. Further, a significant improvement in tumor response is obtained when PDT is delivered during hyperoxygenation. When PDT is combined with hyperoxygenation, the hypoxic condition is improved and the cell killing rate at various time points after PDT is significantly enhanced. Photosensitization with use of porphyrins is used with HBO(2) and PDT for treatment of certain tumors. PDT with ALA is used for treatment of actinic keratosis (AK). The combination of iron administration (by injection or oral rout), hemin, or transferrin, as a source for iron, HBO(2) as a source of oxygen under pressure and PDT as a source of generating free-radical tissue damage may be useful in the treatment of tumors. The possibility of combining HBO(2), iron, light and local photosensitizers to overcome skin tumors deserve extensive laboratory and clinical research work. Conclusively, iron, HBO(2), and PDT may have synergistic effect to hamper tumor cells.

International Central Nervous System and Ocular Lymphoma Workshop: Recommendations for the Future

Purpose: To bring together multidisciplinary experts to discuss primary central nervous system lymphoma (PCNSL) and primary intraocular lymphoma (PIOL). Methods: NIH campus workshop discussion focusing on future work in both clinical and basic lymphoma research. Results: The discussion lead to recommendations on elucidating disease pathobiology, improving diagnostic accuracy and sensitivity, and novel therapeutic strategies. Conclusions: Approaches which have been successfully applied to other neoplasms, such as microarray, may be applied to improve diagnostic accuracy and sensitivity of PCNSL and PIOL and should be systematically incorporated into clinical trials of both. Development of animal models of PCNSL and PIOL may be useful in understanding the unique ocular and CNS milieu. Disease detection by radiological, nuclear medicine, molecular and flow cytometric approaches should be systematically studied to improve early diagnosis, accurate staging, and response evaluation. Improved therapy remains the ultimate goal. Efforts in these arenas should be coordinated on a national and international level.

Reflections on therapeutic trials in primary biliary cirrhosis: A quality of life oriented counter-view

To the editor: A recent placebo-controlled, multi-center clinical trial, published in Hepatology, has reported that the addition of methotrexate to ursodeoxycholic acid (UDCA) therapy has no discernable effect on survival, or time to transplantation, in primary biliary cirrhosis (PBC).1 Although obviously disheartened by the efforts he and his colleagues have put in to what transpired to be a negative trial, we feel that the accompanying, rather pessimistic, editorial by Combes is far too narrow in its outlook.2 In this editorial Combes argues that it is difficult, if not impossible, to envisage future improvement in therapy in PBC. Whilst morbidity and mortality are of fundamental importance as goals in the treatment of any disease, we would argue that it is just as important that clinicians look to treat patients' symptoms and to improve their quality of life (QOL). This is particularly important in a condition such as PBC where significant impairment of QOL is recognised, typically resulting from symptoms such as fatigue, which are unrelated to disease severity.3-6 The importance of improvement in QOL as a goal of therapy in its own right, is made all the more pertinent by the observation, made so elegantly by Combes and colleagues, that outcomes in terms of survival are actually very good, almost regardless of therapy in young PBC patients with early disease (although it should be noted that the outcome in terms of survival may be less rosy in older patient groups).7 Whilst the Combes trial looked at end points including mortality, liver transplantation and clinical parameters, there is no mention of symptomatic and/or QOL assessment. In light of the low mortality demonstrated, and the likelihood that, if the patients are at all representative, they have substantial (but non-assessed) impairment of their QOL, it could be argued that the most important outcome measure was not studied. The counter view to Combes is that what is needed in PBC is not pessimism but realism about the true nature of the impact that the disease has on patients and, accordingly, a paradigm shift in treatment goals. Although the search for novel additional pharmacological therapies able to stop disease progression continues, there is a persuasive argument that patients who progress on UDCA would do so with other agents, and that transplantation will be required by those patients who do progress in any case. However, even in patients in whom the disease is only slowly progressive, the symptoms of the disease can have a major impact on QOL. Ameliorating symptoms and improving QOL in such patients would be of major practical benefit to large numbers of patients. We have a duty of care as clinicians and researchers to look at QOL in our PBC patients and we would suggest that, in the future, at least as much effort be put in to clinical research and trial work in the area of improving QOL, as in to high concept, large scale and long term mortality-orientated trials which as Combes acknowledges have generated relatively little benefit to patients to date. David E.J. Jones*, Neeraj Bhala*, Julia L. Newton*, * Liver Research Group, School of Clinical Medical Sciences, University of Newcastle, Newcastle-upon-Tyne, UK

Model for Gene‐Environment Interaction: The Case for Dialysis

Organ complications in end-stage renal disease (ESRD) such as cardiovascular disease, anemia, bone disease, malnutrition, inflammation, and infections occur in many organ systems and are caused by a multitude of underlying disease-, uremia-, and therapy-related factors, and with a wide range of manifestations and severity. Interindividual variability in the pathophysiologic response of the uremic host to environmental factors, including renal replacement therapy, may be governed to a significant degree by genetic susceptibility factors. Specific genes regulate the pathophysiologic responses of organ systems affected by ESRD and can serve as candidate genes for the host-environment interaction. This review summarizes emerging clinical and translational research work in the field of genetic polymorphism of candidate genes and their effects on the development of organ complications in ESRD. Methodologic limitations of the existing published data, the need for large prospective cohort studies, and potential future risks for the use of genomic information in resource allocation are also highlighted.

Surgical Strategy in Obstetric Brachial Plexus Palsy: The Aachen Experience

We present our personal experience with 650 children suffering from obstetric brachial plexus palsy. We describe the related surgery including early microsurgical nerve reconstruction and later tendon and muscle transfers. We discuss our clinical approach, the indications and timing for surgery, the technical details of primary and secondary surgery in our hands, and the possible outcome. We emphasize that both clinical work and research work need an interdisciplinary team approach and that diagnostic, therapeutic, and prognostic improvement is based on the refinements of our (micro)surgical skill and the continuous exchange of information between specialized centers.

Restoring the harmony and order of the body: treatment of cancer patients according to syndrome differentiation

By reviewing the clinical work of the past 40 years and combining with the theories of traditional Chinese medicine, the author proposed that the spleen plays a key role in treating liver cancer according to syndrome differentiation. Based on the clinical and experimental research work, the author advanced a theory that the goal of the treatment of cancer according to syndrome differentiation is to restore the harmony and order of the body. Further research into this theory will be conducive to establishing a new theoretical system of integrative medicine on cancer treatment.

Torture and the borders of humanity

When the history of the group violently crosses the path of the history of the individual, that process calls for an interdisciplinary examination. Such interdisciplinarity turns out to yield undeniable benefits for the study of the deliberate injuring of one human being by another. In this article, a psychologist and a historian set out to tackle some of the questions raised by one extreme kind of violence, torture. What are its aims? What underlies its methods, and what are its mechanisms, once we look below the surface? Who are the torturers, and how are they made? What escape is there from torture ‐not just from the victim's point of view, but the torturer's as well? Testimony, case studies from clinical practice and research work are offered in support of their suggestions.

July 16, 2002

HomeCirculationVol. 106, No. 3July 16, 2002 Free AccessAnnouncementPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAnnouncementPDF/EPUBJuly 16, 2002Rapid Access Publication James T. Willerson, MD James T. WillersonJames T. Willerson Search for more papers by this author Originally published16 Jul 2002https://doi.org/10.1161/circ.106.3.283Circulation. 2002;106:283The Editors of Circulation are pleased to announce that our effort to provide even more rapid access to all original scientific articles that have been accepted for publication in Circulation began with our first issue of the new year. All original clinical and basic manuscripts, once accepted, will now be published Online five to nine working days after galley proofs are returned from the author to Lippincott Williams & Wilkins. Rapid Access Publication will enable individual and institutional subscribers to log on to the Circulation web site, www.circ.ahajournals.org, and access the pdf file of a group of manuscripts that was accepted just days earlier. These same manuscripts will be published in the print journal within 4 to 5 weeks. Editorials and review articles are not included in Rapid Access Publication. This new opportunity for rapid publication of accepted manuscripts allows Circulation to make important information available to its readers in an even more timely fashion.Rapid Track for Review and PublicationThe Editors of Circulation wish to remind readers of a special category of manuscripts we initiated nearly two years ago. Rapid Track for Publication is a category of manuscript submission designed for expedited review, and if accepted, expedited publication of manuscripts reporting the results of important clinical trials and major basic science discoveries. We are committed to providing an initial decision one week after the manuscript enters the review process. If the manuscript is accepted for publication, it will be published Online one week after galley proofs are returned to our publisher, and in the print journal within four to five weeks. We are pleased to offer this special opportunity for very rapid review and publication of the most important clinical and basic research work submitted to Circulation.Clinician Update and Cardiology Patient PageDr Elliott Antman is the Section Editor for two new sections that were introduced in the Online version of Circulation in May and June, 2001. The new sections are available as a collection through radio buttons on the home page of Circulation Online, and now each new article is published rapidly in the print journal as well. We are pleased to offer the new sections as a review for the physician and as a resource for the patient.Cardiovascular NewsImages in Cardiovascular MedicineMagnetic Resonance Angiography of a Congenitally Interrupted Aortic ArchAnitha Varghese, MRCP, BSc; Michael, Gatzoulis, MD; Raad H. Mohiaddin, MRCP, FRCR(Circulation. 2002;106:e9-e10.)Book Reviews(Circulation. 2002;106:e11-e12.) Previous Back to top Next FiguresReferencesRelatedDetailsCited By Gong N, Bodi I, Zobel C, Schwartz A, Molkentin J and Backx P (2006) Calcineurin Increases Cardiac Transient Outward K+ Currents via Transcriptional Up-regulation of Kv4.2 Channel Subunits, Journal of Biological Chemistry, 10.1074/jbc.M607774200, 281:50, (38498-38506), Online publication date: 1-Dec-2006. July 16, 2002Vol 106, Issue 3 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.106.3.283 Originally publishedJuly 16, 2002 PDF download Advertisement

July 19, 2002

HomeCirculationVol. 106, No. 2July 19, 2002 Free AccessAnnouncementPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAnnouncementPDF/EPUBJuly 19, 2002 James T. Willerson, MD James T. WillersonJames T. Willerson Search for more papers by this author Originally published9 Jul 2002https://doi.org/10.1161/circ.106.2.161Circulation. 2002;106:161Rapid Access PublicationThe Editors of Circulation are pleased to announce that our effort to provide even more rapid access to all original scientific articles that have been accepted for publication in Circulation began with our first issue of the new year. All original clinical and basic manuscripts, once accepted, will be published Online five to nine working days after galley proofs are returned from the author to Lippincott Williams & Wilkins. Rapid Access Publication will enable individual and institutional subscribers to log on to the Circulation web site, www.circ.ahajournals.org, and access the pdf file of a group of manuscripts that was accepted just days earlier. These same manuscripts will be published in the print journal within 4 to 5 weeks. Editorials and review articles are not included in Rapid Access Publication. This new opportunity for rapid publication of accepted manuscripts allows Circulation to make important information available to its readers in an even more timely fashion.Rapid Track for Review and PublicationThe Editors of Circulation wish to remind readers of a special category of manuscripts we initiated nearly two years ago. Rapid Track for Publication is a category of manuscript submission designed for expedited review, and if accepted, expedited publication of manuscripts reporting the results of important clinical trials and major basic science discoveries. We are committed to providing an initial decision one week after the manuscript enters the review process. If the manuscript is accepted for publication, it will be published Online one week after galley proofs are returned to our publisher, and in the print journal within four to five weeks. We are pleased to offer this special opportunity for very rapid review and publication of the most important clinical and basic research work submitted to Circulation.Clinician Update and The Cardiology Patient PageDr Elliott Antman is the Section Editor for two new sections that were introduced in the Online version of Circulation in May and June, 2001. The new sections are available as a collection through radio buttons on the home page of Circulation Online, and now each new article is published rapidly in the print journal as well. We are pleased to offer the new sections as a review for the physician and as a resource for the patient.Cardiovascular NewsImages in Cardiovascular MedicineRight and Left Ventricular Outflow Tract Obstruction in Hypertrophic CardiomyopathySagar N. Doshi, BSc, MBChB, MRCP; Michael C. Kim, MD; Samin K. Sharma, MD; Valentin Fuster, MD, PhD(Circulation. 2002;106:e3– e4.)Correspondence(Circulation. 2002;106:e5– e8.) Previous Back to top Next FiguresReferencesRelatedDetails July 9, 2002Vol 106, Issue 2 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.106.2.161 Originally publishedJuly 9, 2002 PDF download Advertisement

June 11, 2002

HomeCirculationVol. 105, No. 23June 11, 2002 Free AccessOtherPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessOtherPDF/EPUBJune 11, 2002Rapid Access Publication James T. Willerson, MD and James T. WillersonJames T. Willerson Search for more papers by this author and Search for more papers by this author and for the Editors of Circulation Originally published11 Jun 2018https://doi.org/10.1161/01.cir.0000530638.35468.72Circulation. 2002;105:2695The Editors of Circulation are pleased to announce that our effort to provide even more rapid access to all original scientific articles that have been accepted for publication in Circulation began with our first issue of the new year. All original clinical and basic manuscripts, once accepted, will be published Online five to nine working days after galley proofs are returned from the author to Lippincott Williams & Wilkins. Rapid Access Publication will enable individual and institutional subscribers to log on to the Circulation web site, www.circ.ahajournals.org, and access the pdf file of a group of manuscripts that was accepted just days earlier. These same manuscripts will be published in the print journal within 4 to 5 weeks. Editorials and review articles are not included in Rapid Access Publication. This new opportunity for rapid publication of accepted manuscripts allows Circulation to make important information available to its readers in an even more timely fashion.Rapid Track for Review and PublicationThe Editors of Circulation wish to remind readers of a special category of manuscripts we initiated nearly two years ago. Rapid Track for Publication is a category of manuscript submission designed for expedited review, and if accepted, expedited publication of manuscripts reporting the results of important clinical trials and major basic science discoveries. We are committed to providing an initial decision one week after the manuscript enters the review process. If the manuscript is accepted for publication, it will be published Online one week after galley proofs are returned to our publisher, and in the print journal within four to five weeks. We are pleased to offer this special opportunity for very rapid review and publication of the most important clinical and basic research work submitted to Circulation.Clinician Update and The Cardiology Patient PageDr Elliott Antman is the Section Editor for two new sections that were introduced in the Online version of Circulation in May and June, 2001. The new sections are available as a collection through radio buttons on the home page of Circulation Online, and now each new article is published rapidly in the print journal as well. We are pleased to offer the new sections as a review for the physician and as a resource for the patient.Cardiovascular NewsImages in Cardiovascular MedicineRoles of Low and Oscillating Shear Stress?Attila Thury, MD; Jolanda J. Wentzel, PhD; Ruud V.H. Vinke, MSc; Frank J.H. Gijsen, PhD; Johan C.H. Schuurbiers, BSc; Rob Krams, MD, PhD; Pim J. de Feyter, MD, PhD; Patrick W. Serruys, MD, PhD; Cornelis J. Slager, PhD (Circulation. 2002; 105:e185-e187Google Scholar.) Correspondence (Circulation. 2002; 105:e188-e191Google Scholar.) Previous Back to top Next FiguresReferencesRelatedDetails June 11, 2002Vol 105, Issue 23 Advertisement Article InformationMetrics https://doi.org/10.1161/01.cir.0000530638.35468.72 Originally publishedJune 11, 2018 PDF download Advertisement

June 4, 2002

HomeCirculationVol. 105, No. 22June 4, 2002 Free AccessAnnouncementPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAnnouncementPDF/EPUBJune 4, 2002Rapid Access Publication James T. Willerson, MD James T. WillersonJames T. Willerson Search for more papers by this author Originally published4 Jun 2002https://doi.org/10.1161/circ.105.22.2573Circulation. 2002;105:2573The Editors of Circulation are pleased to announce that our effort to provide even more rapid access to all original scientific articles that have been accepted for publication in Circulation began with our first issue of the new year. All original clinical and basic manuscripts, once accepted, will now be published Online five to nine working days after galley proofs are returned from the author to Lippincott Williams & Wilkins. Rapid Access Publication will enable individual and institutional subscribers to log on to the Circulation web site, www.circ.ahajournals.org, and access the pdf file of a group of manuscripts that was accepted just days earlier. These same manuscripts will be published in the print journal within 4 to 5 weeks. Editorials and review articles are not included in Rapid Access Publication. This new opportunity for rapid publication of accepted manuscripts allows Circulation to make important information available to its readers in an even more timely fashion.Rapid Track for Review and PublicationThe Editors of Circulation wish to remind readers of a special category of manuscripts we initiated nearly two years ago. Rapid Track for Publication is a category of manuscript submission designed for expedited review, and if accepted, expedited publication of manuscripts reporting the results of important clinical trials and major basic science discoveries. We are committed to providing an initial decision one week after the manuscript enters the review process. If the manuscript is accepted for publication, it will be published Online one week after galley proofs are returned to our publisher, and in the print journal within four to five weeks. We are pleased to offer this special opportunity for very rapid review and publication of the most important clinical and basic research work submitted to Circulation.Clinician Update and Cardiology Patient PageDr Elliott Antman is the Section Editor for two new sections that were introduced in the Online version of Circulation in May and June, 2001. The new sections are available as a collection through radio buttons on the home page of Circulation Online, and now each new article is published rapidly in the print journal as well. We are pleased to offer the new sections as a review for the physician and as a resource for the patient.Cardiovascular NewsImages in Cardiovascular MedicineAngiographic Evidence of Coronary-Subclavian Steal SyndromeC. R. Kroll, MD; M. Agarwal, MD; G. A. Stouffer, MD (Circulation. 2002; 105:e184Google Scholar.) Previous Back to top Next FiguresReferencesRelatedDetails June 4, 2002Vol 105, Issue 22 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.105.22.2573 Originally publishedJune 4, 2002 PDF download Advertisement

May 14, 2002

HomeCirculationVol. 105, No. 19May 14, 2002 Free AccessAnnouncementPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAnnouncementPDF/EPUBMay 14, 2002Rapid Access Publication James T. Willerson, MD James T. WillersonJames T. Willerson Search for more papers by this author Originally published14 May 2002https://doi.org/10.1161/circ.105.19.2241Circulation. 2002;105:2241The Editors of Circulation are pleased to announce that our effort to provide even more rapid access to all original scientific articles that have been accepted for publication in Circulation began with our first issue of the new year. All original clinical and basic manuscripts, once accepted, will be published Online five to nine working days after galley proofs are returned from the author to Lippincott Williams & Wilkins. Rapid Access Publication will enable individual and institutional subscribers to log on to the Circulation web site, www.circ.ahajournals.org, and access the pdf file of a group of manuscripts that was accepted just days earlier. These same manuscripts will be published in the print journal within 4 to 5 weeks. Editorials and review articles are not included in Rapid Access Publication. This new opportunity for rapid publication of accepted manuscripts allows Circulation to make important information available to its readers in an even more timely fashion.Rapid Track for Review and PublicationThe Editors of Circulation wish to remind readers of a special category of manuscripts we initiated nearly two years ago. Rapid Track for Publication is a category of manuscript submission designed for expedited review, and if accepted, expedited publication of manuscripts reporting the results of important clinical trials and major basic science discoveries. We are committed to providing an initial decision one week after the manuscript enters the review process. If the manuscript is accepted for publication, it will be published Online one week after galley proofs are returned to our publisher, and in the print journal within four to five weeks. We are pleased to offer this special opportunity for very rapid review and publication of the most important clinical and basic research work submitted to Circulation.Clinician Update and The Cardiology Patient PageDr Elliott Antman is the Section Editor for two new sections that were introduced in the Online version of Circulation in May and June, 2001. The new sections are available as a collection through radio buttons on the home page of Circulation Online, and now each new article is published rapidly in the print journal as well. We are pleased to offer the new sections as a review for the physician and as a resource for the patient.for the Editors of CirculationCardiovascular NewsImages in Cardiovascular MedicineTruncus Arteriosus and Double Aortic ArchJean-François Paul, MD; Alain Serraf, MDCirculation. 2002;105:e170.)Correspondence(Circulation. 2002;105:e171-e175.) Previous Back to top Next FiguresReferencesRelatedDetails May 14, 2002Vol 105, Issue 19 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.105.19.2241 Originally publishedMay 14, 2002 PDF download Advertisement

April 30, 2002

HomeCirculationVol. 105, No. 17April 30, 2002 Free AccessAnnouncementPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAnnouncementPDF/EPUBApril 30, 2002Rapid Access Publication James T. Willerson, MD James T. WillersonJames T. Willerson Search for more papers by this author Originally published30 Apr 2002https://doi.org/10.1161/circ.105.17.2007Circulation. 2002;105:2007The Editors of Circulation are pleased to announce that our effort to provide even more rapid access to all original scientific articles that have been accepted for publication in Circulation began with our first issue of the new year. All original clinical and basic manuscripts, once accepted, will be published Online five to nine working days after galley proofs are returned from the author to Lippincott Williams & Wilkins. Rapid Access Publication will enable individual and institutional subscribers to log on to the Circulation web site, www.circ.ahajournals.org, and access the pdf file of a group of manuscripts that was accepted just days earlier. These same manuscripts will be published in the print journal within 4 to 5 weeks. Editorials and review articles are not included in Rapid Access Publication. This new opportunity for rapid publication of accepted manuscripts allows Circulation to make important information available to its readers in an even more timely fashion.Rapid Track for Review and PublicationThe Editors of Circulation wish to remind readers of a special category of manuscripts we initiated nearly two years ago. Rapid Track for Publication is a category of manuscript submission designed for expedited review, and if accepted, expedited publication of manuscripts reporting the results of important clinical trials and major basic science discoveries. We are committed to providing an initial decision one week after the manuscript enters the review process. If the manuscript is accepted for publication, it will be published Online one week after galley proofs are returned to our publisher, and in the print journal within four to five weeks. We are pleased to offer this special opportunity for very rapid review and publication of the most important clinical and basic research work submitted to Circulation.Clinician Update and The Cardiology Patient PageDr Elliott Antman is the Section Editor for two new sections that were introduced in the Online version of Circulation in May and June, 2001. The new sections are available as a collection through radio buttons on the home page of Circulation Online, and now each new article is published rapidly in the print journal as well. We are pleased to offer the new sections as a review for the physician and as a resource for the patient.Cardiovascular NewsImages in Cardiovascular MedicinePulmonary Vein Exit-Block During Radio-Frequency Ablation of Paroxysmal Atrial FibrillationOsnat Gurevitz, MD; Paul A. Friedman, MD (Circulation. 2002; 105:e124–e125Google Scholar.) Correspondence (Circulation. 2002; 105:e126–e129Google Scholar.) Previous Back to top Next FiguresReferencesRelatedDetailsCited By Paulraj P and Paul B (2011) Metal microchannel lamination using surface mount adhesives for low-temperature heat exchangers, Journal of Manufacturing Processes, 10.1016/j.jmapro.2011.01.001, 13:2, (85-95), Online publication date: 1-Aug-2011. April 30, 2002Vol 105, Issue 17 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.105.17.2007 Originally publishedApril 30, 2002 PDF download Advertisement

April 23, 2002

HomeCirculationVol. 105, No. 16April 23, 2002 Free AccessAnnouncementPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAnnouncementPDF/EPUBApril 23, 2002Rapid Access Publication James T. Willerson, MD James T. WillersonJames T. Willerson Search for more papers by this author Originally published23 Apr 2002https://doi.org/10.1161/circ.105.16.1873Circulation. 2002;105:1873The Editors of Circulation are pleased to announce that our effort to provide even more rapid access to all original scientific articles that have been accepted for publication in Circulation began with our first issue of the new year. All original clinical and basic manuscripts, once accepted, will be published Online five to nine working days after galley proofs are returned from the author to Lippincott Williams & Wilkins. Rapid Access Publication will enable individual and institutional subscribers to log on to the Circulation web site, www.circ.ahajournals.org, and access the pdf file of a group of manuscripts that was accepted just days earlier. These same manuscripts will be published in the print journal within 4 to 5 weeks. Editorials and review articles are not included in Rapid Access Publication. This new opportunity for rapid publication of accepted manuscripts allows Circulation to make important information available to its readers in an even more timely fashion.Rapid Track for Review and PublicationThe Editors of Circulation wish to remind readers of a special category of manuscripts we initiated nearly two years ago. Rapid Track for Publication is a category of manuscript submission designed for expedited review, and if accepted, expedited publication of manuscripts reporting the results of important clinical trials and major basic science discoveries. We are committed to providing an initial decision one week after the manuscript enters the review process. If the manuscript is accepted for publication, it will be published Online one week after galley proofs are returned to our publisher, and in the print journal within four to five weeks. We are pleased to offer this special opportunity for very rapid review and publication of the most important clinical and basic research work submitted to Circulation.Clinician Update and The Cardiology Patient PageDr Elliott Antman is the Section Editor for two new sections that were introduced in the Online version of Circulation in May and June, 2001. The new sections are available as a collection through radio buttons on the home page of Circulation Online, and now each new article is published rapidly in the print journal as well. We are pleased to offer the new sections as a review for the physician and as a resource for the patient.Cardiovascular NewsImages in Cardiovascular MedicineFormation of a Free Floating Left Atrial Thrombus Despite Three Weeks of AnticoagulationM. Timur Selcuk, MD; Hatice Selcuk, MD; Bilal Geyik, MD; Irfan Sabah, MD (Circulation. 2002; 105:e122-e123Google Scholar.) Previous Back to top Next FiguresReferencesRelatedDetails April 23, 2002Vol 105, Issue 16 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.105.16.1873 Originally publishedApril 23, 2002 PDF download Advertisement

April 16, 2002

HomeCirculationVol. 105, No. 15April 16, 2002 Free AccessAnnouncementPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAnnouncementPDF/EPUBApril 16, 2002Rapid Access Publication James T. Willerson, MD James T. WillersonJames T. Willerson Search for more papers by this author Originally published16 Apr 2002https://doi.org/10.1161/circ.105.15.1745Circulation. 2002;105:1745The Editors of Circulation are pleased to announce that our effort to provide even more rapid access to all original scientific articles that have been accepted for publication in Circulation began with our first issue of the new year. All original clinical and basic manuscripts, once accepted, will be published Online five to nine working days after galley proofs are returned from the author to Lippincott Williams & Wilkins. Rapid Access Publication will enable individual and institutional subscribers to log on to the Circulation web site, www.circ.ahajournals.org, and access the pdf file of a group of manuscripts that was accepted just days earlier. These same manuscripts will be published in the print journal within 4 to 5 weeks. Editorials and review articles are not included in Rapid Access Publication. This new opportunity for rapid publication of accepted manuscripts allows Circulation to make important information available to its readers in an even more timely fashion.Rapid Track for Review and PublicationThe Editors of Circulation wish to remind readers of a special category of manuscripts we initiated nearly two years ago. Rapid Track for Publication is a category of manuscript submission designed for expedited review, and if accepted, expedited publication of manuscripts reporting the results of important clinical trials and major basic science discoveries. We are committed to providing an initial decision one week after the manuscript enters the review process. If the manuscript is accepted for publication, it will be published Online one week after galley proofs are returned to our publisher, and in the print journal within four to five weeks. We are pleased to offer this special opportunity for very rapid review and publication of the most important clinical and basic research work submitted to Circulation.Clinician Update and The Cardiology Patient PageDr Elliott Antman is the Section Editor for two new sections that were introduced in the Online version of Circulation in May and June, 2001. The new sections are available as a collection through radio buttons on the home page of Circulation Online, and now each new article is published rapidly in the print journal as well. We are pleased to offer the new sections as a review for the physician and as a resource for the patient.Cardiovascular NewsImages in Cardiovascular MedicineFibrillary/Immunotactoid Glomerulopathy With Cardiac InvolvementMarc S. Sabatine, MD; H. Thomas Aretz, MD; Leslie S.T. Fang, MD, PhD; G. William Dec, MD; (Circulation. 2002; 105:e120-e121Google Scholar.) Previous Back to top Next FiguresReferencesRelatedDetails April 16, 2002Vol 105, Issue 15 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.105.15.1745 Originally publishedApril 16, 2002 PDF download Advertisement

April 9, 2002

HomeCirculationVol. 105, No. 14April 9, 2002 Free AccessAnnouncementPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAnnouncementPDF/EPUBApril 9, 2002Rapid Access Publication James T. Willerson, MD and James T. WillersonJames T. Willerson Search for more papers by this author and Search for more papers by this author and for the Editors of Circulation Originally published9 Apr 2002https://doi.org/10.1161/circ.105.14.1619Circulation. 2002;105:1619The Editors of Circulation are pleased to announce that our effort to provide even more rapid access to all original scientific articles that have been accepted for publication in Circulation began with our first issue of the new year. All original clinical and basic manuscripts, once accepted, will now be published Online five to nine working days after galley proofs are returned from the author to Lippincott Williams & Wilkins. Rapid Access Publication will enable individual and institutional subscribers to log on to the Circulation web site, www.circ.ahajournals.org, and access the pdf file of a group of manuscripts that was accepted just days earlier. These same manuscripts will be published in the print journal within 4 to 5 weeks. Editorials and review articles are not included in Rapid Access Publication. This new opportunity for rapid publication of accepted manuscripts allows Circulation to make important information available to its readers in an even more timely fashion.Rapid Track for Review and PublicationThe Editors of Circulation wish to remind readers of a special category of manuscripts we initiated nearly two years ago. Rapid Track for Publication is a category of manuscript submission designed for expedited review, and if accepted, expedited publication of manuscripts reporting the results of important clinical trials and major basic science discoveries. We are committed to providing an initial decision one week after the manuscript enters the review process. If the manuscript is accepted for publication, it will be published Online one week after galley proofs are returned to our publisher, and in the print journal within four to five weeks. We are pleased to offer this special opportunity for very rapid review and publication of the most important clinical and basic research work submitted to Circulation.Clinician Update and The Cardiology Patient PageDr Elliott Antman is the Section Editor for two new sections that were introduced in the Online version of Circulation in May and June, 2001. The new sections are available as a collection through radio buttons on the home page of Circulation Online, and now each new article is published rapidly in the print journal as well. We are pleased to offer the new sections as a review for the physician and as a resource for the patient.Cardiovascular NewsImages in Cardiovascular MedicinePersistent Left Superior Vena Cava Demonstrated With Multislice Spiral Computed TomographyThomas C. Gerber, MD; Ronald S. Kuzo, MD (Circulation. 2002; 105:e79Google Scholar.) Correspondence (Circulation. 2002; 105:e80-e85Google Scholar.) AbstractsAbstracts From the Asia Pacific Scientific Forum: Bench to Bedside to Community and the 42nd Annual Conference on Cardiovascular Disease Epidemiology and Prevention (Circulation. 2002; 105:e86–e119Google Scholar.) Previous Back to top Next FiguresReferencesRelatedDetails April 9, 2002Vol 105, Issue 14 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.105.14.1619 Originally publishedApril 9, 2002 PDF download Advertisement

April 2, 2002

HomeCirculationVol. 105, No. 13April 2, 2002 Free AccessAnnouncementPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAnnouncementPDF/EPUBApril 2, 2002Rapid Access Publication James T. Willerson, MD and James T. WillersonJames T. Willerson Search for more papers by this author and Search for more papers by this author and for the Editors of Circulation Originally published2 Apr 2002https://doi.org/10.1161/circ.105.13.1513Circulation. 2002;105:1513The Editors of Circulation are pleased to announce that our effort to provide even more rapid access to all original scientific articles that have been accepted for publication in Circulation began with our first issue of the new year. All original clinical and basic manuscripts, once accepted, will be published Online five to nine working days after galley proofs are returned from the author to Lippincott Williams & Wilkins. Rapid Access Publication will enable individual and institutional subscribers to log on to the Circulation web site, www.circ.ahajournals.org, and access the pdf file of a group of manuscripts that was accepted just days earlier. These same manuscripts will be published in the print journal within 4 to 5 weeks. Editorials and review articles are not included in Rapid Access Publication. This new opportunity for rapid publication of accepted manuscripts allows Circulation to make important information available to its readers in an even more timely fashion.Rapid Track for Review and PublicationThe Editors of Circulation wish to remind readers of a special category of manuscripts we initiated nearly two years ago. Rapid Track for Publication is a category of manuscript submission designed for expedited review, and if accepted, expedited publication of manuscripts reporting the results of important clinical trials and major basic science discoveries. We are committed to providing an initial decision one week after the manuscript enters the review process. If the manuscript is accepted for publication, it will be published Online one week after galley proofs are returned to our publisher, and in the print journal within four to five weeks. We are pleased to offer this special opportunity for very rapid review and publication of the most important clinical and basic research work submitted to Circulation.Clinician Update and The Cardiology Patient PageDr Elliott Antman is the Section Editor for two new sections that were introduced in the Online version of Circulation in May and June, 2001. The new sections are available as a collection through radio buttons on the home page of Circulation Online, and now each new article is published rapidly in the print journal as well. We are pleased to offer the new sections as a review for the physician and as a resource for the patient.Cardiovascular NewsImages in Cardiovascular MedicineUnusual Angiographic Appearance of Scimitar Syndrome Associated With Primitive Hepatic Venous PlexusNandini Madan, MD; John W. Moore, MD, MPH (Circulation. 2002; 105:e78Google Scholar.) Previous Back to top Next FiguresReferencesRelatedDetails April 2, 2002Vol 105, Issue 13 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.105.13.1513 Originally publishedApril 2, 2002 PDF download Advertisement

February 19, 2002

HomeCirculationVol. 105, No. 7February 19, 2002 Free AccessAnnouncementPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAnnouncementPDF/EPUBFebruary 19, 2002Rapid Access Publication James T. Willerson, MD James T. WillersonJames T. Willerson Search for more papers by this author Originally published19 Feb 2002https://doi.org/10.1161/circ.105.7.781Circulation. 2002;105:781The Editors of Circulation are pleased to announce that our effort to provide even more rapid access to all original scientific articles that have been accepted for publication in Circulation began with our first issue of the new year. All original clinical and basic manuscripts, once accepted, will be published Online five to nine working days after galley proofs are returned from the author to Lippincott Williams & Wilkins. Rapid Access Publication will enable individual and institutional subscribers to log on to the Circulation web site, www.circ.ahajournals.org, and access the pdf file of a group of manuscripts that was accepted just days earlier. These same manuscripts will be published in the print journal within 4 to 5 weeks. Editorials and review articles are not included in Rapid Access Publication. This new opportunity for rapid publication of accepted manuscripts allows Circulation to make important information available to its readers in an even more timely fashion.Rapid Track for Review and PublicationThe Editors of Circulation wish to remind readers of a special category of manuscripts we initiated nearly two years ago. Rapid Track for Publication is a category of manuscript submission designed for expedited review, and if accepted, expedited publication of manuscripts reporting the results of important clinical trials and major basic science discoveries. We are committed to providing an initial decision one week after the manuscript enters the review process. If the manuscript is accepted for publication, it will be published Online one week after galley proofs are returned to our publisher, and in the print journal within four to five weeks. We are pleased to offer this special opportunity for very rapid review and publication of the most important clinical and basic research work submitted to Circulation.Clinician Update and The Cardiology Patient PageDr Elliott Antman is the Section Editor for two new sections that were introduced in the Online version of Circulation in May and June, 2001. The new sections are available as a collection through radio buttons on the home page of Circulation Online, and now each new article is published rapidly in the print journal as well. We are pleased to offer the new sections as a review for the physician and as a resource for the patient.Cardiovascular NewsImages in Cardiovascular MedicinePostoperative Dislocation of the Heart After PneumonectomyJens Rodenwaldt, MD; Alexander E. Lembcke, MD; Till H. Wiese, MD;Sebastian Höhn; Bernd K. Hamm, MD (Circulation. 2002; 105:e49–e50Google Scholar.) Previous Back to top Next FiguresReferencesRelatedDetails February 19, 2002Vol 105, Issue 7 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.105.7.781 Originally publishedFebruary 19, 2002 PDF download Advertisement