To expand work‐family conflict (WFC) research to specific occupations, this study investigated how work and family generic and occupation‐specific stressors and support variables related to family interfering with work (F → W) and work interfering with family (W → F) among 230 Israeli high school teachers. Further expanding WFC research, the authors assessed WFC effects on burnout and vigor. Results indicated that W → F conflict was related to generic variables and more so to distinctive teaching characteristics (e.g., investment in student behavior and parent‐teacher relations). Both W → F and F → W predicted burnout, whereas only F → W predicted vigor. Implications for WFC research and occupational health programs are discussed.