Memory For Words Research Articles

The role of speech style, frequency, and density in recognition memory for spoken words.

What determines whether listeners remember a spoken word? The Effortfulness Hypothesis claims that memory is modulated by a word's intelligibility during real-time processing, while the Distinctiveness Hypothesis claims that it is modulated by a word's distinguishing characteristics. We tested these differing predictions using American English words that varied along three dimensions known to affect both intelligibility and distinctiveness: speech style (clear versus casual), frequency (high versus low), and neighborhood density (high versus low). In a recognition memory experiment, participants (n = 66) listened to a set of study words, and then gave yes/no judgments to indicate whether or not they had heard the word earlier. Results showed that those words which exhibited distinctive characteristics - whether due to clear speech style, low frequency, or low density - were remembered better. The finding supports the Distinctiveness Hypothesis, suggesting that our capacity for remembering words relies on their distinctiveness, rather than on our capacity for recognizing them in real time.

Drawing improves memory in patients with hippocampal damage.

The hippocampus plays a critical role in the formation of declarative memories, and hippocampal damage leads to significant impairments in new memory formation. Drawing can serve as a form of multi-modal encoding that improves declarative memory performance relative to other multimodal encoding strategies such as writing. We examined whether, and to what extent, patients with hippocampal damage could benefit from the mnemonic strategy of drawing. Three patients with focal hippocampal damage, and one patient with both hippocampal and cortical lesions, in addition to 22 age-, sex-, and education-matched controls, were shown a list of words one at a time during encoding and instructed to either draw a picture or repeatedly write each word for 40 s. Following a brief filled delay, free recall and recognition memory for words from both encoding trial types were assessed. Controls showed enhanced recall and recognition memory for words drawn versus those that were written, an effect that was even more pronounced in patients with focal hippocampal damage. By contrast, the patient with both hippocampal and cortical lesions showed no drawing-mediated boost in either recall or recognition memory. These findings demonstrate that drawing is an effective encoding strategy, likely accruing from the engagement of extra-hippocampal processes including the integration of cortical-based motor, visual, and semantic processing, enabling more elaborative encoding.

Lowered cutoffs to reduce false positives on the Word Memory Test

ABSTRACT Objective To adjust the decision criterion for the Word Memory Test (WMT, Green, 2003) to minimize the frequency of false positives. Method Archival data were combined into a database (n = 3,210) to examine the best cut score for the WMT. We compared results based on the original scoring rules and those based on adjusted scoring rules using a criterion based on 16 performance validity tests (PVTs) exclusive of the WMT. Cutoffs based on peer-reviewed publications and test manuals were used. The resulting PVT composite was considered the best estimate of validity status. We focused on a specificity of .90 with a false-positive rate of less than .10 across multiple samples. Results Each examinee was administered the WMT, as well as on average 5.5 (SD = 2.5) other PVTs. Based on the original scoring rules of the WMT, 31.8% of examinees failed. Using a single failure on the criterion PVT (C-PVT), the base rate of failure was 45.9%. When requiring two or more failures on the C-PVT, the failure rate dropped to 22.8%. Applying a contingency analysis (i.e., X2) to the two failures model on the C-PVT measure and using the original rules for the WMT resulted in only 65.3% agreement. However, using our adjusted rules for the WMT, which consisted of relying on only the IR and DR WMT subtest scores with a cutoff of 77.5%, agreement between the adjusted and the C-PVT criterion equaled 80.8%, for an improvement of 12.1% identified. The adjustmeny resulted in a 49.2% reduction in false positives while preserving a sensitivity of 53.6%. The specificity for the new rules was 88.8%, for a false positive rate of 11.2%. Conclusions Results supported lowering of the cut score for correct responding from 82.5% to 77.5% correct. We also recommend discontinuing the use of the Consistency subtest score in the determination of WMT failure.

Countable alphabet stationary processes with at least one memory word and intermittent estimation with universal rates

Countable alphabet stationary processes with at least one memory word and intermittent estimation with universal rates

Exploring the Production Effect in Memory Reveals a Balanced Bilingual Advantage.

There is evidence suggesting that bilingual individuals demonstrate an advantage over monolinguals in performing various tasks related to memory and executive functions. The characteristics of this bilingual advantage are not unanimously agreed upon in the literature, and some even doubt it exists. The heterogeneity of the bilingual population may explain this inconsistency. Hence, it is important to identify different subgroups of bilinguals and characterize their cognitive performance. The current study focuses on the production effect, a well-established memory phenomenon, in bilingual young adults differing in their English and Hebrew proficiency levels, and the possible balanced bilingual advantage. The aims of this study are (1) to evaluate the production effect in three groups of bilingual participants: English-dominant bilinguals, Hebrew-dominant bilinguals, and balanced bilinguals, and (2) to examine whether memory advantage depends on varying degrees of bilingualism. One hundred twenty-one bilingual young adults who speak English and Hebrew at different levels participated. All learned lists of familiar words, in English and Hebrew, half by reading aloud and half by silent reading, followed by free recall tests. As expected, a production effect (better memory for aloud words than for silent words) was found for all groups in both languages. Balanced bilinguals remembered more words than did dominant participants, demonstrating a memory advantage in both languages. These findings support the hypothesis that the presence of cognitive advantage in bilingualism depends on the acquisition of a good proficiency level in each of the languages, with direct implications for family language policy and bilingual education.

The Impact of Linguistic Prediction Violations on Downstream Recognition Memory and Sentence Recall.

Predicting upcoming words during language comprehension not only affects processing in the moment but also has consequences for memory, although the source of these memory effects (e.g., whether driven by lingering pre-activations, re-analysis following prediction violations, or other mechanisms) remains underspecified. Here, we investigated downstream impacts of prediction on memory in two experiments. First, we recorded EEG as participants read strongly and weakly constraining sentences with expected, unexpected but plausible, or semantically anomalous endings ("He made a holster for his gun / father / train") and were tested on their recognition memory for the sentence endings. Participants showed similar rates of false alarms for predicted but never presented sentence endings whether the prediction violation was plausible or anomalous, suggesting that these arise from pre-activation of the expected words during reading. During sentence reading, especially in strongly constraining sentences, plausible prediction violations elicited an anterior positivity; anomalous endings instead elicited a posterior positivity, whose amplitude was predictive of later memory for those anomalous words. ERP patterns at the time of recognition differentiated plausible and anomalous sentence endings: Words that had been plausible prediction violations elicited enhanced late positive complex amplitudes, suggesting greater episodic recollection, whereas anomalous sentence endings elicited greater N1 amplitudes, suggesting attentional tagging. In a follow-up behavioral study, a separate group of participants read the same sentence stimuli and were tested for sentence-level recall. We found that recall of full sentences was impaired when sentences ended with a prediction violation. Taken together, the results suggest that prediction violations draw attention and affect encoding of the violating word, in a manner that depends on plausibility, and that this, in turn, may impair future memory of the gist of the sentence.

Spontaneous Production Rates in Song and Speech

Many everyday tasks appear to be performed at an optimal rate that differs between individuals but is consistent within individuals. These optimal rates are estimated using a participant's Spontaneous Production Rate (SPR), the rate at which an individual produces sequences of sounds in the absence of external tempo cues. A previous study that measured SPRs in speech and piano production found no association between SPRs across tasks, a result suggesting that domain-specific constraints determine optimal rates. The present study addressed whether this dissociation would remain when music and speech are produced with the same effector system: vocal production. Participants spoke short, well-known phrases and sang familiar children's songs on “da” to avoid memorization of words. SPRs were measured by the mean inter-onset interval (IOI) between successively produced syllables or tones and showed large individual differences. Results showed consistent SPRs within individuals within each domain (speaking or singing) as well as consistent SPRs across the speaking and singing conditions. These results align with theories of optimal rates based on energy efficiency arising from biomechanical constraints rather than domain-specific communication goals.

Neurometabolic therapy of mild cognitive impairment in patients with chronic cerebral ischemia

To evaluate the effect of a sequential therapy regimen with Mexidol (500 mg injections intravenously for 14 days) and Mexidol FORTE 250 (250 mg tablets 3 times a day for 60 days) on higher cortical functions in patients with moderate cognitive disorders in chronic cerebral ischemia. A comparative, prospective study included 63 patients with chronic cerebral ischemia with moderate cognitive impairment. All patients received basic therapy aimed at reducing risk factors (antihypertensive, antithrombotic drugs as indicated). Patients of the main group (30 people: 12 men, 18 women) received Mexidol intravenously 500 mg in 100 ml of 0.9% NaCl solution once a day for 14 days, then Mexidol FORTE 250 (film-coated tablets) 250 mg 3 times a day for the next 60 days. The comparison group consisted of 33 patients (14 men, 19 women) who received only basic therapy. The groups were comparable in terms of age, sex characteristics and severity of cognitive deficit. We examined cognitive status (MoCA scale, Frontal Dysfunction Battery, 10 Word Memorization tests), severity of asthenia (MFI-20 scale), anxiety and depression (HADS scale), patient's subjective assessment of the dynamics of the condition (CGI-improvement scale) in 1st, 14th and 74th±5 days of observation. On days 1 and 74±5 of observation, patients were examined using transcranial magnetic stimulation to study the neuronal activity of the cerebral cortex. In the main group, at the time of completion of taking Mexidol and Mexidol FORTE 250, a pronounced cognitive regression was noted (MoCA scale +3 points, difference with the comparison group 1 point (p<0.0001); Frontal Dysfunction Battery test +4 points, difference with comparison group 2 points (p<0.001); memory test «10 words» +2 points, difference with the comparison group 1 point (p<0.05), emotional (HADS anxiety scale -8 points, difference with the comparison group 3 points (p<0.001), depression -3.5 points, difference with the comparison group 1.5 points (p<0.01), asthenic disorders (MFI-20 scale -30 points, difference with the comparison group 15.5 points (p<0.01), improvement in the well-being of patients (CGI-improvement scale -2 points, difference with the comparison group 1 point (p<0.0001). According to the transcranial magnetic stimulation performed, a statistically significant decrease in the central motor conduction time at the level of 1 and 2 motor neurons of the pyramidal tract bilaterally from the start to the end of therapy with Mexidol and Mexidol FORTE 250 was determined (p<0.01). An inverse correlation was found between the time of central motor conduction and the results of the Frontal Dysfunction Battery test at the same time points with left-sided localization of 1 motor neuron (p<0.01). The results of a study of the use of sequential therapy with Mexidol 500 mg IV drip 1 time per day for 14 days followed by oral administration of Mexidol FORTE 250 1 tablet 3 times a day for 60 days indicate its clinical effectiveness and safety in patients with chronic cerebral ischemia with mild cognitive impairment, and also confirm its importance for preventing the progression of cognitive disorders.

A 30-day kendama program for community-dwelling elderly: Effects on participants' physical and cognitive functions and the practicality of the program.

This study examined the effects of a 30-day kendama program on physical and cognitive functions and the practicality of the program for community-dwelling elderly individuals to reduce the risk of dementia and musculoskeletal disorders. Seventeen community-dwelling elderly persons aged ≥65 years participated in a 30-day kendama program wherein they practiced kendama in groups once a week for a total of four times and individually for at least 20 minutes a day for 30 days. The frequency and duration of the group and individual practices were surveyed to assess the practicality of the program. The physical function assessment revealed that knee extension muscle strength increased significantly by 18.8% after the intervention (p < 0.01). Further, the cognitive function assessment showed that the time required to perform the Stroop test decreased by 10.1%, the number of Symbol Digit Modalities Tests (SDMTs) performed increased by 5.6%, and the number of correct answers in the word memory test increased by 17.8% after the intervention, with each showing a significant change (p < 0.05). The results of the questionnaire on the participants' 30-day kendama program showed that approximately 30% answered that the frequency of individual practice was "a little too much," indicating that the program needed to be modified. The results of this study suggested that kendama can be enjoyed easily and is expected to be practiced continuously with friends. Therefore, kendama can serve as an exercise program for reducing the risk of dementia and musculoskeletal disorders. In the future, it will be necessary to reconsider the frequency of individual kendama practice.

PERSONALITY AND WORD RECALL AS INTERACTIVE PREDICTORS OF PERCEIVED MEMORY ABILITY

Abstract Cognitive gerontology research requires consideration of both actual performance and perceptions of performance. While subjective memory perceptions are positively associated with memory performance, these correlations typically are modest in magnitude. Therefore, researchers have noted the need to consider potential moderators of this association, to better understand whether certain people show weaker or stronger linkages between performance and perceptions. The current study leveraged personality (NEO Big Five), memory performance (i.e., word recall), and perceptions of memory ability (i.e., metamemory in adulthood scale and subjective memory complaints) data from the St. Louis Personality and Aging Network (SPAN) study (n = 774, mean age: 71.52 years). Personality traits were more associated with subjective than objective memory, and the most consistent associations were for extraversion (r = -.20 for complaints, r = .26 for metamemory) and conscientiousness (r = -.26 for complaints and r = .33 for metamemory). Moreover, extraversion moderated associations between word recall and both memory capacity and complaints. Results suggested that associations between word recall and the two subjective indicators were weaker for those adults higher in extraversion, relative to adults who scored lower on extraversion. One possible interpretation is that extraverted older adults may construct their cognitive self-perceptions using information from their social interactions more than objective cues. These findings highlight the need to determine how personality traits influence which sources of information older adults employ when thinking about their cognitive ability, which in turn may explain their choices for activity engagement.

A lack of retrieval practice effects in children's recognition and recall memory of novel words during storybook reading

IntroductionRetrieval practice enhances adults' long-term memory over restudying. However, it is less clear whether young children also benefit from retrieval practice. This study assessed whether retrieval practice could support children's novel word learning in the context of storybook reading.MethodIn Experiments 1–3, preschoolers (N = 167, RangeAge = 26–68 months) were presented with 10 novel word-object pairs across four consecutive storybook readings. Half of the children were read the storybook four times (i.e., SSSS), whereas the other half of the children were read the storybook once and were then asked to retrieve the novel words during the subsequent three readings (i.e., STTT). Children's recall and recognition memory for the novel words was tested after a 5-min delay.Results and discussionResults revealed that although children had high retrieval success during learning, retrieval practice did not provide an advantage over re-reading for children's recall (Experiment 1), even when additional mapping and retrieval opportunities were provided (Experiment 2); that is, children who engaged in retrieval practice did not outperform children who re-read the storybooks. A retrieval practice effect also did not emerge in children's recognition memory of novel words (Experiment 3). Taken together, this study suggests that retrieval practice may only benefit young children under specific learning conditions. Future research should therefore consider characteristics of the learner and broader learning context to explain developmental differences in retrieval practice effects.

Knowledge Graph Construction of Near-Homonymy and Near-Synonymy English Words

This paper investigates the issue of near-homonymy and near-synonymy in English vocabulary learning and explores the significance and practical value of addressing this problem. Through data analysis, we emphasize the widespread demand for English language acquisition and the importance of the English language. Furthermore, we cite research in the field of education to provide evidence of the positive impact of near-homonymy and near-synonymy on word memorization. The main research work of this paper includes the construction of a graph database and the measurement of near-homonymy and near-synonymy. We describe in detail the workflow of building the graph database, including the definition of nodes and edges, as well as edge filtering methods. Additionally, we introduce the mathematical principles and formulas used to calculate near-homonymy and near-synonymy. The experimental section presents the data source and the process of constructing the graph database, including data preprocessing, similarity calculation, and parameter settings. We establish a graph database using neo4j and showcase the intermediate results of near-homonymy and near-synonymy, as well as visualization results. Finally, we summarize the main findings of this paper and discuss the prospects for applying similarity calculations based on word origins.

The attentional boost effect in free recall dynamics.

With the attentional boost effect (ABE), responding to a briefly presented target in a detection task enhances the encoding of other items presented at the same time. However, the effects of target detection on context memory for the event in which the stimulus appeared remain unclear. Here, we present findings from verbal free recall and recognition experiments that test the effects of target detection during encoding on temporal and relational aspects of context memory. Consistent with prior demonstrations of limited effects of target detection on context memory, in Experiment 1 there was no evidence that target detection influenced the likelihood of transitioning to items that were presented at similar times during encoding, or that were in the same encoding condition. These null effects were replicated in a second experiment, which added an old/new recognition and relational memory test. These results indicate that target detection during encoding has minimal effects on the formation of temporal associations between words in memory.

Multimodal Exercise and Cognitive Training Program Improves Cognitive Function in Amnestic Mild Cognitive Impairment

To investigate the preliminary efficacy of a combined physical exercise + cognitive training intervention for older adults with amnestic mild cognitive impairment (aMCI). Randomized clinical trial. Veteran Affairs Hospital, Palo Alto, CA. Sample included 72 community-dwelling volunteers (mean age 72.4 ± 9.5) diagnosed with aMCI. Participants were randomized to either a combined aerobic and resistance exercise + cognitive training (CARE+CT) or stretching exercise + CT (SE+CT). Primary outcomes included intervention specific assessments of word list and name-face recall. Secondary cognitive outcomes included standardized composite scores that reflect cognitive domains (e.g., learning and memory, executive function, processing speed, visuospatial ability, language). Secondary physiological outcomes included VO2 max and functional capacity (e.g., distance walked 6-minute walk test). APOE and BDNF were determined from whole blood samples. Controlling for age and employment status, linear mixed effects models revealed that all participants experienced significant improvement in the delayed recall of word list, learning and memory and executive function. Only the CARE+CT condition had significant improvement in processing speed and functional capacity. APOE4 status impacted cognitive benefits of those in the SE+CT condition. Results provide preliminary support for combined exercise and cognitive training interventions for older adults with aMCI. Further research is needed to understand the mechanisms involved as well as the impact of these interventions in diverse samples. ClinicalTrials.gov Identifier: NCT01962038.

Reading for Meaning: The Influence of Reader Characteristics on Paragraph Understanding in Aphasia.

The study improves our understanding of the reading comprehension difficulties seen in people with aphasia. It investigates the influence of reader characteristics, including personal demographic variables, and linguistic and wider cognitive skills, on text comprehension. Seventy-five people with aphasia and 87 neurologically typical readers completed a test of paragraph comprehension. People with aphasia also completed background tests of language, attention, recognition memory, and executive functions. The influence of demographic variables (age, gender, and level of education) was analyzed separately in the group of people with aphasia and the typical readers using analyses of variance. In the people with aphasia, the relationship between paragraph comprehension and the language and cognitive tests was explored using correlational analyses. In the typical readers, there was a significant effect of gender and level of education and a significant three-way interaction. For the people with aphasia, there were no significant effects of demographic variables. Significant positive correlations were found between performance on paragraph comprehension and each of the language tests and with tests of auditory attention, executive functions, and recognition memory for words. In people with aphasia, the effects of demographic variables were overshadowed by the effect of their language difficulties. The association seen across language measures reflects the shared semantic representations across single-word, sentence, and text levels, across modalities. The study emphasizes the importance of attention, executive functions, and short-term memory in the comprehension of and memory for what we read. The contribution of both language difficulties and wider cognitive skills needs to be considered when planning intervention. https://doi.org/10.23641/asha.24695451.

Modelling orthographic similarity effects in recognition memory reveals support for open bigram representations of letter coding

A variety of letter string representations has been proposed in the reading literature to account for empirically established orthographic similarity effects from masked priming studies. However, these similarity effects have not been explored in episodic memory paradigms and very few memory models have employed orthographic representation of words. In the current work, through two recognition memory experiments employing word and pseudoword stimuli respectively, we empirically established a set of key orthographic similarity effects for the first time in recognition memory – namely the substitution effect, transposition effect and reverse effect in recognition memory of words and pseudowords, and a start-letter importance in recognition memory of words. Subsequently, we compared orthographic representations from the reading literature including slot coding, closed-bigram, open-bigram and the overlap model. Each of these representations was situated in a global matching model and fitted to recognition performance via Luce’s choice rule in a hierarchical Bayesian framework. Model selection results showed support for the open-bigram representation in both experiments.

Reflection, Memory, and the Fine Art of Poetry: Reading Memories of Words by Jaydeep Sarangi

Reflection, Memory, and the Fine Art of Poetry: Reading Memories of Words by Jaydeep Sarangi

Enhanced memory for negative words is associated with amnestic mild cognitive impairment and in vivo cerebral amyloid‐β burden independently of depression

AbstractBackgroundEmotion dysregulation was studied as a potential risk marker for Alzheimer’s disease (AD) by assessing emotional memory in high AD‐risk groups characterized by the presence of mild cognitive impairment (MCI) or remitted major depressive disorder (rMDD) and by evaluating the relationship between emotional memory and in vivo cerebral amyloid‐β deposition.Method435 participants enrolled in the PACt‐MD clinical trial of cognitive remediation plus transcranial direct current stimulation were evaluated at baseline. The sample included 127 older adults with amnestic mild cognitive impairment (aMCI), 51 non‐amnestic MCI (naMCI), 60 rMDD without MCI, 81 rMDD+aMCI, 42 rMDD+naMCI, and 74 cognitively unimpaired older adults (CU). Diagnoses were established during a consensus conference based on psychiatric, medical, and neuropsychological assessment. Emotional memory was assessed by evaluating immediate and short‐term delayed recall of 15 personality adjectives (5 each of positive, negative and neutral words) from the Emotional Verbal Learning Test (Mah et al., 2017, American Journal of Geriatric Psychiatry, 25:1160). A subset (N = 167) completed a Positron Emission Tomography (PET) scan with carbon‐11 Pittsburgh Compound B ([11C] PIB). Valence and diagnostic group effects on recall were assessed using mixed ANOVA. Regression modelling assessed the association between emotional memory bias and amyloid‐β burden.ResultRelative to CU, both aMCI and rMDD+aMCI groups showed enhanced memory for negative words at immediate recall, which persisted after short delay in the aMCI group only (F(1, 339) = 2.66, p = .048; Figure 1). Enhanced memory for negative words at short delay was predictive of in vivo cerebral amyloid‐β deposition (standardized beta = .117, t = 1.84, p = .067), over and above the contributions of age, sex, Apolipoprotein E genotype, depression diagnosis and symptoms, and long delayed verbal recall (F(4,154) = 25.8, p&lt;.001, R2 = .41; Figure 2).ConclusionThe association between enhanced memory for negative personality adjectives and aMCI replicates earlier work in single‐domain aMCI (Mah et al., 2017) and suggests that aMCI is characterized by a negativity bias in memory. These findings, taken together with the relationship between a negativity bias in memory and amyloid‐β burden, suggest that emotion dysregulation, in the form of enhanced memory for negative information, is a potential marker of AD risk.

Drawing enhances memory for emotional words.

Past work has demonstrated that drawing a sketch, compared to writing during encoding, improves memory of to-be-remembered words, pictures, and academic terms. We examined whether this benefit extended to emotional materials. In Experiment 1, negative, positive, and neutral words were presented in an encoding phase, with intermixed prompts to either write out or draw a picture representing the word. Participants later freely recalled words by writing them out. Recall was higher for words drawn than for words written at encoding, and the magnitude of the benefit was differentially enhanced for emotional compared to neutral words. In Experiment 2, negative, positive, and neutral words were again presented but encoding type was compared using pure lists between participants. The pattern of memory performance replicated that observed in Experiment 1. Further, the use of drawing as an encoding technique interacted with emotionality, whereby emotional words that were drawn were best remembered. Our results demonstrate that the memory benefit conferred by drawing at encoding extends to emotional materials. Our findings suggest that the use of drawing as an encoding strategy, and the emotionality of the stimulus itself, contributes independently to enhance retention. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Primacy and recency effects in verbal memory are differentially associated with post‐mortem frontal cortex p‐tau217 level in a mixed sample of community‐dwelling older adults

AbstractBackgroundEmerging research indicates plasma phosphorylated (p)‐tau217 levels may demonstrate sensitivity to preclinical and symptomatic Alzheimer’s disease (AD). Serial position effects (primacy and recency) in verbal memory are sensitive cognitive markers of early AD; however associations between these measures and p‐tau217 in postmortem brain samples are unclear. In a mixed sample of older adults, this study examined how primacy and recency scores measured years before death are associated with post‐mortem levels of p‐tau217, with p‐tau202 as a complementary post‐mortem measure of early tau phosphorylation.MethodData were used from the Rush University Religious Orders Study and the Memory and Aging Project. Participants were 1098 community‐dwelling older adults (68.9% female, M age = 80.1) who were non‐demented at baseline and followed until death (M follow‐up years = 9.2; status at death: 34.7% unimpaired, 26.0% mild cognitive impairment, 39.3% dementia). Baseline serial position scores were calculated as the proportion of words recalled from the beginning (primacy) and end (recency) of the CERAD Word Memory List. A neuropathological exam classified Braak stage. A middle frontal gyrus tissue sample was used to quantify p‐tau217 and p‐tau202 with selected reaction monitoring proteomics. Linear regression analyses examined associations of cognitive scores with p‐tau, adjusting for age, sex, education, APOE e4 status, Braak stage, and time to death.ResultAs expected, higher Braak scores were associated with higher levels of brain p‐tau217. In the fully adjusted model, higher baseline primacy scores (b = ‐.27, p = .026), but not recency scores (b = ‐.02, p = .901), were associated with lower levels of p‐tau217 but not p‐tau202 in middle frontal cortex. Higher delayed recall (b = ‐.08, p = .007), but not immediate recall (b = ‐.01, p = .071), was also associated with lower p‐tau217.ConclusionPrimacy scores measured years before death were associated with the outcome of post‐mortem brain levels of p‐tau217, but not p‐tau202. The differential associations of serial position scores with p‐tau suggest they may add complementary information about early neuropathological changes when used in conjunction with routine delayed recall scores. These findings further contribute to evidence for p‐tau217 as a sensitive biomarker of AD.