The seismic performance of residential woodframe buildings has a widespread and lasting impact on the socioeconomic vitality of a community. To enable efficient seismic risk and resilience assessment, a comprehensive framework that is rooted in performance-based earthquake engineering (PBEE) methodology is proposed. The framework is formulated as a computational workflow which is operationalized as an automation program dubbed “Auto-WoodSDA”. The end-to-end platform is developed to perform four major tasks: (1) generate code-compliant seismic design, (2) create numerical models, (3) perform nonlinear analyses, and (4) assess earthquake-induced financial losses and functional recovery time. Given the user inputs, Auto-WoodSDA sequentially executes the four tasks without intermediate human intervention to produce seismic performance metrics such as the expected annual loss. It is presented as a ready-to-implement platform that is computationally efficient and scalable in performing large-scale seismic risk and resilience assessment. An example building from the existing literature is used to demonstrate the key features of the automation framework and verify the results. The results underscore the ability of the AutoWoodSDA computational workflow to automate the generation of reliable new code-compliant woodframe building designs, perform nonlinear analysis, and assess the earthquake-induced impacts using PBEE principles.