Oak wood (Quercus spp.) is the traditional and widely utilized raw material for wooden barrels deployed for the maturation of alcoholic beverages. The chemical compounds, extractives, lignin, hemicellulose, and others, in the wood are claimed to significantly influence the sensory attributes of the beverages during the aging process. The study aimed to assess the chemical properties of non-oak wood species. These species include Sandoricum koetjape (Burm. f.) Merr., Swietenia macrophylla King, Acacia mangium Willd., and Eucalyptus camaldulensis Dehnh., which are all locally available. The investigation was prompted by the limited availability and exorbitant fees associated with the importation of oak barrels into the country. The chemical properties of these non-oak wood species were compared to those of Quercus alba. The effects of tree species (TS) and tree portions (TP) on the chemical properties were evaluated using different TAPPI and ASTM methods. Results showed that S. macrophylla had the highest solubilities with 29.12, 14.64, and 9.09% in 1% sodium hydroxide solution, hot water, and ethanol-cyclohexane, respectively – higher than the solubilities of Q. alba in the three solvents. Meanwhile, E. camaldulensis had the highest lignin content (23.82%), whereas S. koetjape had the lowest lignin and S. macrophylla had the highest hemicellulose content. Q. alba had higher lignin content than all the species studied. The species’ alpha-cellulose contents were lower than that of Q. alba, whereas their holocellulose values were higher. Overall, the effect of TP (top, middle, and bottom) on the chemical composition of each of the wood samples was determined to have little to no effect on the chemical properties, hence indicating a relatively homogeneous distribution of chemical components from top to bottom. On the other hand, TS highly significant effect on the wood species on all the chemical properties analyzed. Overall, locally available non-oak wood species could be suitable as a raw material for wooden barrel fabrication. However, there is a need to conduct further studies on their anatomical, physico-mechanical, and other chemical properties.