Wood Bark Research Articles

Waste-to-Energy Conversion of Rubberwood Residues for Enhanced Biomass Fuels: Process Optimization and Eco-Efficiency Evaluation

Torrefaction was applied to enhance the fuel properties of sawdust (SD) and bark wood (BW), biomass wastes from the rubberwood processing industry. Design Expert (DE) software was used in an experimental design to study the effects of affecting factors including torrefaction temperature and time as well as the biomass size towards the desirable properties such as HHV, mass yield, fixed carbon content, and eco-efficiency values. Promising results showed that the HHVs of the torrefied SD (25 MJ/kg) and BW (26 MJ/kg) were significantly increased when compared to preheated SD (17 MJ/kg) and preheated BW (17 MJ/kg) and in a range similar to that of coal (25–35 MJ/kg). The TGA, FTIR, biomass compositions, and O/C ratios suggested that thermochemical reactions played a significant role in the torrefaction at which thermal degradation coupled with possible in situ chemical reactions took place, to some extent. The optimal conditions of the torrefaction were identified at 320 °C and 30 min for SD, and 325 °C and 30 min for BW. The maximum HHVs at the optimal condition were 22, 23, and 20 MJ/kg while the eco-efficiency values were 29.18, 27.89, and 13.72 kJ/kg CO2_eq*THB for torrefied SD, torrefied BW, and coal, respectively. The findings of this study indicate that torrefied rubberwood residues enhanced HHV, eco-efficiency, and less contribution to CO2 emissions compared to fossil fuels.

The Gut Microbiome and Lignocellulose Digestion in Constrictotermes cyphergaster (Termitidae: Nasutitermitinae): A Termite Incorporating Lichen into Its Diet

Lichen-feeding termites occupy a distinctive ecological niche. This feeding behavior underscores a complex interplay between the termites’ digestive abilities and the biochemical properties of lichens, known for their resilience and production of secondary metabolites. Understanding the dietary preferences and digestive mechanisms of these termites offers insights into their ecological roles and the evolutionary adaptations that enable them to exploit such a specialized food source. We conducted experiments with Constrictotermes cyphergaster, feeding it with different combinations of its natural food sources: wood bark and lichen from host trees. Gut microbial communities were analyzed through 16S rRNA sequencing and shotgun metagenomics. Our results revealed that a diet containing lichens induces a shift in microbiota composition and increases the abundance of genes encoding an AA3 enzyme with a role in lignin digestion. This study emphasizes the potential role of lichens in enhancing the digestive capabilities of termites, highlighting the intricate relationships between diet, gut microbiota, and enzymatic activity in Termitidae.

Nordalbergin Synergizes with Novel β-Lactam Antibiotics against MRSA Infection.

The synergetic strategy has created tremendous advantages in drug-resistance bacterial infection treatment, whereas challenges related to novel compound discovery and identifying drug-binding targets still remain. The mechanisms of antimicrobial resistance involving β-lactamase catalysis and the degradation of β-lactam antibiotics are being revealed, with relevant therapies promising to improve the efficacy of existing major classes of antibiotics in the foreseeable future. In this study, it is demonstrated that nordalbergin, a coumarin isolated from the wood bark of Dalbergia sissoo, efficiently potentiated the activities of β-lactam antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) by suppressing β-lactamase performance and improving the bacterial biofilm susceptibility to antibiotics. Nordalbergin was found to destabilize the cell membrane and promote its permeabilization. Moreover, nordalbergin efficiently improved the therapeutic efficacy of amoxicillin against MRSA pneumonia in mice, as supported by the lower bacterial load, attenuated pathological damage, and decreased inflammation level. These results demonstrate that nordalbergin might be a promising synergist of amoxicillin against MRSA infections. This study provided a new approach for developing potentiators for β-lactam antibiotics against MRSA infections.

A techno-economic and environmental analysis of co-firing implementation using coal and wood bark blend at circulating fluidized bed boiler

The study aimed to explore the effects of biomass co-firing of coal using acacia wood bark at circulating fluidized bed (CFB) boiler coal-fired power plant with 110 MWe capacity. The analysis focused on main equipment parameters, including the potential for slagging, fouling, corrosion, agglomeration, fuel cost, and specific environmental factors. Initially, coal and acacia wood bark fuel were blended at a 3% mass ratio, with calorific values of 8.59 MJ/kg and 16.59 MJ/kg, respectively. The corrosion due to chlorine and slagging potential when using wood bark was grouped into the minor and medium categories. The results showed that co-firing at approximately 3% mass ratio contributed to changes in the upper furnace temperature due to the variation in heating value, high total humidity, and a less homogeneous particle size distribution. Significant differences were also observed in the temperature of the lower furnace area, showing the presence of a foreign object covering the nozzle, which disturbed the ignition process. A comparison of the seal pot temperature showed imbalances as observed from the temperature indicators installed on both sides of boiler, with specific fuel consumption (SFC) increasing by approximately 0.17%. During the performance test, the price of acacia wood bark was 0.034 USD/kg, resulting in fuel cost of 0.023355 USD/kWh, adding 0.061 cent/kWh to coal firing cost. Despite co-firing, the byproducts of the combustion process, such as SO2 and NOx, still met environmental quality standards in accordance with government regulations. However, a comprehensive medium- and long-term impact evaluation study should be carried out to implement co-firing operations using acacia wood bark at coal-fired power plant. Based on the characteristics, such as low calorific value, with high ash, total moisture, and alkali, acacia wood bark showed an increased potential to cause slagging and fouling.

L-Arginine Doped Carbon Nanodots from Cinnamon Bark for Improved Fluorescent Yeast Cell Imaging.

In this study, we present an economical and efficient synthesis method for carbon nanodots (CNDs) derived from cinnamon bark wood powder, with the incorporation of L-arginine as a dopant at varying ratios (Cinnamon : L-Arginine - 1:0.25, 1:0.5) via a hydrothermal reaction. Extensive structural and optical characterization was conducted through techniques such as FTIR, XRD, HR-TEM, DLS, UV-Vis, and PL spectra, providing a comprehensive understanding of the properties of CNDs and doped-CNDs. Quantum yields (QY) were quantified for synthesized materials, contributing to the assessment of their fluorescence efficiency. The synthesized CNDs were successfully applied for bioimaging of yeast cells, employing fluorescence microscopy to visualize their interaction. Remarkably, L-arginine-doped CNDs exhibited enhanced fluorescence, showcasing the influence of the dopant. The nature of these CNDs was rigorously investigated, confirming their biocompatibility. Notably, this work presents a novel approach to synthesizing CNDs from a renewable and sustainable source, cinnamon bark wood powder, while exploring the effects of L-arginine doping on their optical and biological properties. This work not only contributes to the synthesis and characterization of CNDs but also highlights their potential for diverse applications, emphasizing their structural, optical, and biological attributes. The findings underscore the versatility of CNDs derived from cinnamon bark wood powder and their potential for advancing biotechnological and imaging applications.

Application of the TOPSIS decision-making method for selecting a manufacturing technique for children’s furniture elements with therapeutic functions

Making furniture or furniture elements that account for the needs of children at various stages of development or with psychomotor dysfunctions is very difficult. From the point of view of exploitation and production technology, it is difficult to select a specific material and manufacturing technique. In this article, the results of using the APEKS method, which is a type of Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method, are presented to select the best solution for the production of children’s furniture elements with surface structures similar to those of natural materials. Wood bark was selected as a material that, due to the sensory tactile sensations of dysfunctional children, could contribute to therapy and education. Comparative analysis was performed on the basis of the subtractive and additive methods used for manufacturing furniture products. Precise multiaxis milling of ash wood and 3D printing with fused filament fabrication technology using wood PLA filaments were carried out. The method used to select the best option considered quantitative and qualitative criteria in the assessment. Various parameters characterizing the surfaces were analyzed, such as geometric dimensions, hill heights, valley depths, and 3D surface parameters. The quality and surface roughness (Sa, Sz, Ssk, Sku, Sp, and Sv) parameters obtained based on 3D microscope measurements were determined. A scale of 1 to 10 was used to assess qualitative factors (i.e., usability and aesthetics). Based on the critical values obtained from the coefficient Kcri = 79.36, it was assumed that multiaxis wood milling was the best method for producing furniture elements with the required surface characteristics for use as therapeutic and educational tools for children with dysfunctions. The applied method allowed an effective evaluation of the compared variants of the production of furniture elements for customized applications.

Integrated anatomical structure, physiological, and transcriptomic analyses to identify differential cold tolerance responses of Ziziphus jujuba mill. ‘Yueguang’ and its autotetraploid ‘Hongguang’

Cold stress is a limiting stress factor that limits plant distribution and development; however, polyploid plants have specific characteristics such as higher resistance to abiotic stress, especially cold stress, that allow them to overcome this challenge. The cultivated cultivar Ziziphus jujuba Mill. ‘Yueguang’ (YG) and its autotetraploid counterpart ‘Hongguang’ (HG) exhibit differential cold tolerance. However, the underlying molecular mechanism and methods to enhance their cold tolerance remain unknown. Anatomical structure and physiological analysis indicated YG had a higher wood bark ratio, and xylem ratio under cold treatment compared to HG. However, the half-lethal temperature (LT50), cortex ratio, and malondialdehyde (MDA) content were significantly decreased in YG than HG, which indicated YG was cold tolerant than HG. Transcriptome analysis showed that 2084, 1725, 2888, and 2934 differentially expressed genes (DEGs) were identified in HC vs YC, H20 vs Y20, Y20 vs YC, and H20 vs HC treatment, respectively. Meanwhile, KEGG enrichment analysis of DEGs showed that several metabolic pathways, primarily plant hormone signal transduction and the MAPK signaling pathway, were involved in the differential regulation of cold tolerance between YG and HG. Furthermore, exogenous abscisic acid (ABA) and brassinolide (BR) treatments could improve their cold tolerance through increased SOD and POD activities, decreased relative electrical conductivity, and MDA content. All of these findings suggested that plant hormone signal transduction, particularly ABA and BR, might have an important role in the regulation of differential cold tolerance between YG and HG, laying the foundation for further improving cold tolerance in jujube and examining the molecular mechanisms underlying differences in cold tolerance among different ploidy cultivars.

Antioxidant, antiproliferative, anti-inflammatory, and enzyme inhibition potentials of Ficus carica wood bark and related bioactive phenolic metabolites

Antioxidant, antiproliferative, anti-inflammatory, and enzyme inhibition potentials of Ficus carica wood bark and related bioactive phenolic metabolites

Влияние химического состава биомассы на процесс агломерации в псевдоожиженном слое котлоагрегата Е-75-3,9-440 ДФТ

The combustion of biofuels in the fluidized bed is an attractive technology to process biomass. However, the technology of biomass combustion in fluidize beds is characterized by several problems associated with the agglomeration of bed material. The aim of the research is to study the influence of the chemical composition of biomass on the agglomeration process of the fluidized bed of the boiler unit E-75-3,9-440 DFT. The boiler burns a mixture of by-products of pulp and paper production to increase stability of the fluidized bed and the duration of boiler operation between periods of its deslagging. The study has tested two types of biomass burned in a mixture in a steam boiler unit E-75-3,9-440 DFT with a fluidized bed. The authors also have studied the samples of agglomerates, bed, and fly ash to find out more about the agglomeration process. The elemental composition of samples of bark-wood waste, sewage sludge, agglomerates and ash has been studied. Elements affecting the process of agglomeration of the fluidized bed have been identified. The results of the analysis have showed that essential ash- and slag-forming components in the sewage sludge are silicon, calcium, sulfur, and potassium, and in the bark wood waste the essential ash- and slag-forming components are calcium, potassium, and sodium. The main elements influencing the process of agglomeration of the fluidized bed are alkaline elements of potassium and sodium. The results obtained make it possible to predict the agglomeration of the fluidized bed, to select the fuel mixture in the proportion necessary to reduce the agglomeration process.

Cytotoxicity and Selectivity of Simpur Air (Dillenia suffruticosa) Wood Bark Fractions Against Cancer Cells

Liver, colon, and cervical cancer are the top three types of cancer which rank in the top five worldwide in terms of incidence and mortality. Simpur air (Dillenia suffruticosa)plant has traditionally been used for the treatment of various diseases, one of which is cancer. This study aims to prove cytotoxic effect and selectivity of simpur air wood bark fractions against liver HepG2, colon WiDr, and cervical HeLa cancer cells. Simpur air wood bark is macerated using 96% methanol. The methanolic crude extract was fractionated with the liquid-liquid partition method using n-hexane and ethyl acetate. Cytotoxicity test using MTT assay method. The result showed that the methanol extract, n-hexane fraction, ethyl acetate fraction, and methanol fraction in liver HepG2 cancer cells had IC50 values 179,32±13,55; 85,14±8,58; 140,08±22,63; >500 µg/mL and in colon WiDr cancer cells had IC50 values 133,02±27,64; 41,54±37,58; 124,76±17,22; >500 µg/mL. Meanwhile, all fractions had IC50 values >500 µg/mL in HeLa cervical cancer cells. These data indicate that the n-hexane fraction in WiDr cells is potentially cytotoxic and selective with a selectivity index value greater than 3. Thus, simpur air wood bark has the potential to be developed as an anticancer drug candidate.

Biomimetic design of flexible wood film combined with thermochromism and self-luminescence for enhanced energy-saving

In this research, the layered bionic wood films were designed and constructed inspired by the “reinforced concrete”-like chemical structure of wood combined with the macrostructure of bark and phloem. Specifically, a simple strategy for immobilizing diol eutectic phase change components with intelligent discoloration/chromogenic leaching in wood by using delignification wood (DE) with capillary penetration was adopted. The “reinforced concrete” structure solves the problem of easy leakage and weak strength due to strong molecular bonding. The bionic wood film has a high phase change enthalpy (155.5 J/g) and suitable phase change temperature (29.9 °C). On this basis, combined with PVA/glycerol as a flexible matrix as the inner bark of wood and phloem connecting each layer, combined with PVA/glycerol/PLO-8C as a key self-luminescent energy-enriched material as the outer bark of wood, the flexible and self-luminescent energy-saving wood films were reconstructed in a biomimetic way with a high mechanical strength (65.53 MPa). Through the change of color, the phase transition process and the current ambient temperature can be intuitively judged. The surface morphology and luminescence intensity were also not affected after 50 cycles of absorption and luminescence. This study provides a broader development direction for the application of intelligent enhanced energy enrichment of PCM-based on bionic wood construction.

Analysis of Combustion Characteristics in Boilers Using Comparison of Coal Fuel Mixtures and Bark Biomass To Determine Optimal Combustion Conditions in a Steam Power Plant

Currently, several material production industries have used self-sustaining power generation systems. Where the most common steam power plant system is found as an option to be used as a source of electricity. The use of biomass as an additional material for fuel in power plant has been widely carried out. This method is more commonly known as cofiring. Analysis of the cofiring combustion system of biomass in the boiler needs to be carried out in order to determine the characteristics of the combustion system that occurs. By varying the composition of the fuel, an analysis of the energy produced from the combustion reaction will be calculated. In this study, the comparison of the use of coal and wood bark was varied at conditions 80:20, 70:30, 60:40, 50:50, 40:60, 30:70, 20:80. Assuming that the steam rate and temperature conditions to be achieved from the combustion products are constant. From the results of the analysis it was found that an increase in the amount of cofiring bark resulted in a decrease in the heating value of the combustion reaction and an increase in fuel capacity. Thus, it can be concluded that the use of bark cofiring in boilers with a coal design is less effective because it will require additional energy to increase the fuel consumption rate and reduce combustion efficiency due to not achieving optimal combustion energy because the initial design combustion chamber capacity is fixed.

Assessment and optimization of co-firing power plant in Thailand: Seasonal effects and dust emission concerns

In this work, the industrial-scale co-fired power plant in Thailand was analyzed and the optimization model was proposed to provide a proper fuel selection for the feedstock seasonal planning to minimize the cost of electricity generation. Also, the dust emission model was introduced in this work to investigate the environmental concern of the proposed fuel formula. The seasonal effects including feed price, properties, and availability were also included in the optimization model. The optimum solution reported a set of fuel formulas for each season that is capable of maintaining power production stability and minimizing fuel costs. Although, the global demand for coal was at its peak in the winter season, using biomass (wood chip, wood bark, and fiber) could increase the production to achieve its minimum requirement. The optimization could reduce the cost of electricity (COE) production by up to 14% (in the winter season). Also, the emission model indicated that to increase the steam production rate to meet the requirement in the summer season, a larger amount of mixed fuel consumption rate was needed. This led to an increase in dust emissions in the summer season. However, in the winter season, the result from optimization could decrease dust emissions by up to 50%. In conclusion, increasing biomass utilization is a favorable option in both economic and environmental aspects.

Assessment of Bark Properties from Various Tree Species in Terms of Its Hydrophobicity and Energy Suitability

Wood bark is a by-product of the forestry industry with significant quantitative potential. Due to the higher heating value and hydrophobic character (dictated by the content of hydrophobic extracts in the chemical composition of the bark) facilitating long-term storage and transport, bark is considered a valuable material to be integrated into the energy industry as a substrate for combustion and co-combustion. However, the heterogeneous structure of the biomass causes significant differences in these parameters between different types of bark. For this reason, this study aimed to analyze the energy usefulness and hydrophobicity of 14 species of bark occurring in large amounts across Europe. Bark’s higher heating value has been shown to range from 17.239 MJ·kg−1 ± 0.318 MJ·kg−1 to 21.618 MJ·kg−1 ± 0.375 MJ·kg−1, and most species are extremely hydrophobic in the WDPT (water drop penetration time; 70–10,495 s) and MED (molarity ethanol droplet; 8.5–24%) tests. Nevertheless, the statistically significant differences between the species in the hydrophobicity tests indicate that the storage of individual types of bark should be adapted to the species and preceded by an analysis of its hydrophobicity. It was also shown that the WDPT test seems to be more suitable for the analysis of highly hydrophobic biomasses, due to the possibility of better differentiation of the level of hydrophobicity between species showing the same degree of hydrophobicity. In addition, the best type of bark that could be implemented in the power industry from the point of view of hydrophobicity and combustion characteristics was Silver Birch bark.

The effect of varnish type, glue amount, and density on the surface properties of low density particleboards produced from waste wood bark

Particleboards, which are widely used in various fields, are commonly coated with solid and liquid surface coating materials to achieve better physical, mechanical, and aesthetic results. This study produced low-density particleboards from waste wood bark using different adhesive mixtures and densities. These particleboards were then coated with three types of varnish: water-based (Aq), polyurethane-based (Pu), and oil/wax-based (Ow). The color, gloss, and surface roughness values of the coated boards were determined to investigate the effect of varnish type, total adhesive usage, and density on these properties. In the board groups produced with the same glue ratio and density, the roughness values obtained with Ow varnish application were mostly higher compared to Aq and Pu. In the Ow varnish type, the roughness (Rmax) decreased linearly with increasing total adhesive amount in particleboards produced at low density (320 kg/m3). The highest color change (ΔE*) values for all variations were obtained in the Ow varnish type, while the highest gloss values were achieved at 85° and in the B2 (4%-420 kg/m3) board group. It was concluded that higher density should be preferred for smoother and glossier surfaces, which are important in terms of surface properties and aesthetics. Overall, these findings highlight the preference for higher density to achieve smoother and glossier surfaces in areas where surface properties and aesthetics are significant.

Sound Absorbing Properties of Selected Green Material—A Review

Noise pollution is often overlooked and invisible, but it significantly impacts the quality of human life. One of the most straightforward solutions to mitigate noise pollution is by using sound-absorbing materials. Recently, research trends to develop sound absorbing green materials, typically derived from agricultural by-products, have witnessed an uptick. This paper summarizes the sound-absorbing properties of various green materials found in the literature, including coconut fiber, kenaf fiber, rice bran, rice husk, rice straw, Hanji (a traditional Korean paper), tea-leaf fiber, mandarin peel, pineapple-leaf fiber, corn husk, peanut shell, sugar palm trunk, yucca gloriosa fiber, fruit stones, wood barks, flax fiber, and nettle fiber. Natural fibers can be made by compressing the raw material or manufacturing them into fibrous materials or composites. The key variables that determine sound absorption performance are the thickness and density of the green material, as well as the presence of an air back cavity. Generally, thicker materials exhibit better sound absorption performance in the low- and mid-frequency range. Moreover, higher density is associated with better sound absorption performance at the same thickness. Additionally, increasing the distance between the sound-absorbing material and the air back cavity enhances sound absorption performance at low frequencies. Thus, these physical variables, rather than the specific materials used, primarily influence sound absorption capabilities. Therefore, various green materials, such as fibers, granules, and porous materials, can be effective sound absorbers if their thickness, density, and air back cavity are properly controlled.

Inhibition of the Acid Corrosion of 10Cr18Ni10Ti and 10Cr18Ni13Mo2Ti Austenitic Steels by Aqueous Extracts of Wood Bark

Inhibition of the Acid Corrosion of 10Cr18Ni10Ti and 10Cr18Ni13Mo2Ti Austenitic Steels by Aqueous Extracts of Wood Bark

Valorization of long-neglected spruce bark and bark-press effluents through integrated utilization of stilbenoids and pectin

Wood bark has exclusively been used for energy at pulp mills, while long-neglected, this huge biomass resource has great potential for valorization. To maximize its value in new ways, here we propose using both fresh (industrial) spruce bark and its bark-press effluents as sustainable sources of natural stilbenoids and pectin. Ultrafiltration removed approximately 90% of the high molecular weight polyphenols as well as enriched stilbenoids from bark-press effluents. Based on a techno-economic analysis, the forest industry would obtain greater revenue potential up to €100 per ton of bark by processing bark side streams compared to their traditional combustion-based strategy if implementing the improved debarking technology. Overall the valorization of stilbenoids and pectin from bark-press effluents or spruce bark offers a promising strategy to produce bio-based, high-value UV-filter ingredients as alternatives to fossil-based ones, and high-grade pectin in an economic feasible and potentially environmentally friendly bolt-on process to the existing mills.

Mechanistic insights and kinetics of torrefaction of pine wood biomasses using solid-state NMR

The purpose of this study is to investigate the potential use of torrefied biomass of the genus Pinus, in the form of wood bark (CC), chips (CV) and wood pellets (PP), as substitutes for metallurgical coke to reduce the high CO2 emissions from the use of metallurgical coke in blast furnaces. Thermogravimetric analysis were used to optimize the torrefaction temperature (250 °C or 290 °C), residence time (30 or 60 min) under inert atmosphere. All of the torrefied biomasses were analyzed to determine physical and chemical characteristics (proximate analyses, ultimate analyses, higher calorific value (HHV), Fourier transform infrared spectroscopy (FTIR) and ss-NMR. The composition of condensable and non-condensable gases formed during torrefaction process were also measured. The results showed that the two most promising biomasses were CV and PP torrefied at a temperature of 290 °C at a residence time of 30 min. The kinetics of torrefaction was analyzed by solid state ss-NMR characterization of the torrefied biomass at different time reactions and temperature (250–290 °C) under inert atmosphere, and followed a pseudo-first order kinetic model. The kinetics of evolution of ss-NMR signals related to C-1 of cellulose; C-4 of cellulose in ordered cellulose; C-4 of cellulose in disordered/amorphous cellulose; C-6 of cellulose, and carbon atoms of methoxyl groups in lignins, at different temperatures were used to estimate the activation energy, and values in the range 11–25 kJ mol−1 were obtained.

Nordalbergin Exerts Anti-Neuroinflammatory Effects by Attenuating MAPK Signaling Pathway, NLRP3 Inflammasome Activation and ROS Production in LPS-Stimulated BV2 Microglia.

Microglia-associated neuroinflammation is recognized as a critical factor in the pathogenesis of neurodegenerative diseases; however, there is no effective treatment for the blockage of neurodegenerative disease progression. In this study, the effect of nordalbergin, a coumarin isolated from the wood bark of Dalbergia sissoo, on lipopolysaccharide (LPS)-induced inflammatory responses was investigated using murine microglial BV2 cells. Cell viability was assessed using the MTT assay, whereas nitric oxide (NO) production was analyzed using the Griess reagent. Secretion of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) was detected by the ELISA. The expression of inducible NO synthase (iNOS), cyclooxygenase (COX)-2, mitogen-activated protein kinases (MAPKs) and NLRP3 inflammasome-related proteins was assessed by Western blot. The production of mitochondrial reactive oxygen species (ROS) and intracellular ROS was detected using flow cytometry. Our experimental results indicated that nordalbergin ≤20 µM suppressed NO, IL-6, TNF-α and IL-1β production; decreased iNOS and COX-2 expression; inhibited MAPKs activation; attenuated NLRP3 inflammasome activation; and reduced both intracellular and mitochondrial ROS production by LPS-stimulated BV2 cells in a dose-dependent manner. These results demonstrate that nordalbergin exhibits anti-inflammatory and anti-oxidative activities through inhibiting MAPK signaling pathway, NLRP3 inflammasome activation and ROS production, suggesting that nordalbergin might have the potential to inhibit neurodegenerative disease progression.