Wisconsin Diagnostic Breast Cancer Dataset Research Articles

Feature Selection and Classification of Clinical Datasets Using Bioinspired Algorithms and Super Learner.

A computer-aided diagnosis (CAD) system that employs a super learner to diagnose the presence or absence of a disease has been developed. Each clinical dataset is preprocessed and split into training set (60%) and testing set (40%). A wrapper approach that uses three bioinspired algorithms, namely, cat swarm optimization (CSO), krill herd (KH) ,and bacterial foraging optimization (BFO) with the classification accuracy of support vector machine (SVM) as the fitness function has been used for feature selection. The selected features of each bioinspired algorithm are stored in three separate databases. The features selected by each bioinspired algorithm are used to train three back propagation neural networks (BPNN) independently using the conjugate gradient algorithm (CGA). Classifier testing is performed by using the testing set on each trained classifier, and the diagnostic results obtained are used to evaluate the performance of each classifier. The classification results obtained for each instance of the testing set of the three classifiers and the class label associated with each instance of the testing set will be the candidate instances for training and testing the super learner. The training set comprises of 80% of the instances, and the testing set comprises of 20% of the instances. Experimentation has been carried out using seven clinical datasets from the University of California Irvine (UCI) machine learning repository. The super learner has achieved a classification accuracy of 96.83% for Wisconsin diagnostic breast cancer dataset (WDBC), 86.36% for Statlog heart disease dataset (SHD), 94.74% for hepatocellular carcinoma dataset (HCC), 90.48% for hepatitis dataset (HD), 81.82% for vertebral column dataset (VCD), 84% for Cleveland heart disease dataset (CHD), and 70% for Indian liver patient dataset (ILP).

Optimization of Classification Accuracy Using K-Means and Genetic Algorithm by Integrating C4.5 Algorithm for Diagnosis Breast Cancer Disease

Technological development resulted in data proliferating. The data is processed into valid information for daily needs. Data mining is a technique to convert data into useful information. Data mining has been widely used in performing prediction functions, for example, health and medical science. This study using Wisconsin Diagnostic Breast Cancer dataset taken from UCI Machine Learning Repository. The dataset has 32 attributes with 569 samples. This data has a continuous and high dimensional data type, and it makes the C4.5 algorithm need long computation time and extensive storage. This study aims to improve the accuracy of the C4.5 with a combination of K-Means and Genetic Algorithm. These study results compared the accuracy of the C4.5 algorithm before and after applying the combination of K-Means and the Genetic Algorithm for diagnosing breast cancer. The accuracy of C4.5 is 91,228%. Meanwhile, the accuracy of C4.5 after optimized using the K-Means and Genetic Algorithm is 94,824%, with the average number of features are selected 22 features. Thus, the application of K-Means and Genetic Algorithm on the C4.5 Algorithm can improve the accuracy of diagnosing breast cancer by 3,596%.

Artificial neural network with Taguchi method for robust classification model to improve classification accuracy of breast cancer.

Artificial neural networks (ANN) perform well in real-world classification problems. In this paper, a robust classification model using ANN was constructed to enhance the accuracy of breast cancer classification. The Taguchi method was used to determine the suitable number of neurons in a single hidden layer of the ANN. The selection of a suitable number of neurons helps to solve the overfitting problem by affecting the classification performance of an ANN. With this, a robust classification model was then built for breast cancer classification. Based on the Taguchi method results, the suitable number of neurons selected for the hidden layer in this study is 15, which was used for the training of the proposed ANN model. The developed model was benchmarked upon the Wisconsin Diagnostic Breast Cancer Dataset, popularly known as the UCI dataset. Finally, the proposed model was compared with seven other existing classification models, and it was confirmed that the model in this study had the best accuracy at breast cancer classification, at 98.8%. This confirmed that the proposed model significantly improved performance.

Entropy Based k Nearest Neighbor Pattern Classification (EbkNN): En-route to Achieving a High Accuracy in Breast Cancer Diagnosis

Entropy based k-Nearest Neighbor pattern classification (EbkNN) is a variation of the conventional k-Nearest Neighbor rule of pattern classification, which exclusively optimizes the value of k-neighbors for each test data based on the calculations of entropy. The formula for entropy used in EbkNN is the one that has been defined popularly in information theory for a set of n different types of information (class) attached to a total of m objects (data points) with each object defined by f features. In EbkNN that value of k is chosen for discrimination of given test data for which the entropy is the least non-zero value. Other rules of conventional kNN are retained in EbkNN. It is concluded that EbkNN works best for binary classification. It is computationally prohibitive to use EbkNN for discriminating the data points of the test dataset into number of classes greater than two. The biggest advantage of EbkNN vis-à-vis the conventional kNN is that in one single run of EbkNN algorithm we get optimum classification of test data. But conventional kNN algorithm has to be run separately for each of the selected range of values of k, and then the optimum k to be chosen from amongst them. We also tested our EbkNN method on WDBC (Wisconsin Diagnostic Breast Cancer) dataset. There are 569 instances in this dataset and we made a random choice of first 290 instances as training dataset and the rest 279 instances as test dataset. We got an exceptionally remarkable result with EbkNN method- accuracy close to 100% and better than the ones got by most of the other researchers who worked on WDBC dataset.

Prediction of Breast Cancer Using Machine Learning

Background: Breast cancer is one of the diseases which cause number of deaths ever year across the globe, early detection and diagnosis of such type of disease is a challenging task in order to reduce the number of deaths. Now a days various techniques of machine learning and data mining are used for medical diagnosis which has proven there metal by which prediction can be done for the chronic diseases like cancer which can save the life’s of the patients suffering from such type of disease. The major concern of this study is to find the prediction accuracy of the classification algorithms like Support Vector Machine, J48, Naïve Bayes and Random Forest and to suggest the best algorithm. Objective: The objective of this study is to assess the prediction accuracy of the classification algorithms in terms of efficiency and effectiveness. Methods: This paper provides a detailed analysis of the classification algorithms like Support Vector Machine, J48, Naïve Bayes and Random Forest in terms of their prediction accuracy by applying 10 fold cross validation technique on the Wisconsin Diagnostic Breast Cancer dataset using WEKA open source tool. Results: The result of this study states that Support Vector Machine has achieved the highest prediction accuracy of 97.89 % with low error rate of 0.14%. Conclusion: This paper provides a clear view over the performance of the classification algorithms in terms of their predicting ability which provides a helping hand to the medical practitioners to diagnose the chronic disease like breast cancer effectively.

Abstract PO-003: Early detection of breast cancer during the Covid-19 pandemic using artificial intelligence neural networks

Abstract Currently, as governments across the world attempt to halt the spread of COVID-19, many of their efforts are being hampered by shortages of crucial testing kits. Even in many developed countries, the health system has come to the point of standstill due to the increasing demand for intensive care units. One study reveals that 40,000 women die in a year from breast cancer, which is one woman every 13 minutes dying from this disease every day. Breast cancer remains the number one form of cancer that women are diagnosed with around the world. Any hospital in the world will have a multidisciplinary team of experts including radiologists, oncologists, surgeons, and other respiratory physicians and consultants. This multidisciplinary team uses a wide variety of data taken from CT scans, x-rays, PET scans, biopsies, clinical examination, imaging mammography, ultrasound (sonography), pathology biopsy, and fine-needle aspiration to identify whether a patient has cancer. Individuals with cancer, particularly those who are receiving systemic anticancer treatments, have been postulated to be at increased risk of mortality from COVID-19. Therefore, it is the need of an hour to implement an early detection of cancer that will prevent patients from COVID-19 and due treatment will be provided. Breast cancer that is detected early is far easier to cure, but at the same time it is difficult to detect. An accurate breast cancer staging is an essential task performed by pathologists (experts who examine the laboratory samples) to inform clinical management for the appropriate treatment. For instance, evaluation of the extent of cancer spread by histopathologic analysis or microscopic examination is an important part of breast cancer staging, and the process involves the decision-making of human behavior with time-consuming and costly sample examination and a period of more than one month to have breast cancer type, stage, etc., to decide the appropriate therapy to patients by the time it can affect the results of therapeutic treatments and survival of patients. The application of artificial intelligence (AI) machine learning technology with deep learning algorithms to whole-slide pathology images can potentially improve the diagnostic accuracy of breast cancer at a very early stage. I have developed a simple machine-learning model using the Python programming language and neural network, inspired by the structure of the human brain, with 12 attributes, out of which 10 real-valued features from each cell nucleus obtained from the Wisconsin diagnostic breast cancer dataset available in public domain for the education capacity that explains about the stage of breast cancer M (Malignant) and B (Benign). This model predicts the presence of breast cancer with an accuracy of 98.8% at a very early stage. The continuous development of technology in the medical field will save countless lives and the overall quality of human life will continue to improve over time. Citation Format: Subash Kumar. Early detection of breast cancer during the Covid-19 pandemic using artificial intelligence neural networks [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2020 Jul 20-22. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(18_Suppl):Abstract nr PO-003.

\u201cSPOCU\u201d: scaled polynomial constant unit activation function

We address the following problem: given a set of complex images or a large database, the numerical and computational complexity and quality of approximation for neural network may drastically differ from one activation function to another. A general novel methodology, scaled polynomial constant unit activation function “SPOCU,” is introduced and shown to work satisfactorily on a variety of problems. Moreover, we show that SPOCU can overcome already introduced activation functions with good properties, e.g., SELU and ReLU, on generic problems. In order to explain the good properties of SPOCU, we provide several theoretical and practical motivations, including tissue growth model and memristive cellular nonlinear networks. We also provide estimation strategy for SPOCU parameters and its relation to generation of random type of Sierpinski carpet, related to the [pppq] model. One of the attractive properties of SPOCU is its genuine normalization of the output of layers. We illustrate SPOCU methodology on cancer discrimination, including mammary and prostate cancer and data from Wisconsin Diagnostic Breast Cancer dataset. Moreover, we compared SPOCU with SELU and ReLU on large dataset MNIST, which justifies usefulness of SPOCU by its very good performance.

Tabu Search and Machine-Learning Classification of Benign and Malignant Proliferative Breast Lesions.

Breast cancer is the most diagnosed cancer among women around the world. The development of computer-aided diagnosis tools is essential to help pathologists to accurately interpret and discriminate between malignant and benign tumors. This paper proposes the development of an automated proliferative breast lesion diagnosis based on machine-learning algorithms. We used Tabu search to select the most significant features. The evaluation of the feature is based on the dependency degree of each attribute in the rough set. The categorization of reduced features was built using five machine-learning algorithms. The proposed models were applied to the BIDMC-MGH and Wisconsin Diagnostic Breast Cancer datasets. The performance measures of the used models were evaluated owing to five criteria. The top performing models were AdaBoost and logistic regression. Comparisons with others works prove the efficiency of the proposed method for superior diagnosis of breast cancer against the reviewed classification techniques.

Correlation-Based Ensemble Feature Selection Using Bioinspired Algorithms and Classification Using Backpropagation Neural Network.

A framework for clinical diagnosis which uses bioinspired algorithms for feature selection and gradient descendant backpropagation neural network for classification has been designed and implemented. The clinical data are subjected to data preprocessing, feature selection, and classification. Hot deck imputation has been used for handling missing values and min-max normalization is used for data transformation. Wrapper approach that employs bioinspired algorithms, namely, Differential Evolution, Lion Optimization, and Glowworm Swarm Optimization with accuracy of AdaBoostSVM classifier as fitness function has been used for feature selection. Each bioinspired algorithm selects a subset of features yielding three feature subsets. Correlation-based ensemble feature selection is performed to select the optimal features from the three feature subsets. The optimal features selected through correlation-based ensemble feature selection are used to train a gradient descendant backpropagation neural network. Ten-fold cross-validation technique has been used to train and test the performance of the classifier. Hepatitis dataset and Wisconsin Diagnostic Breast Cancer (WDBC) dataset from University of California Irvine (UCI) Machine Learning repository have been used to evaluate the classification accuracy. An accuracy of 98.47% is obtained for Wisconsin Diagnostic Breast Cancer dataset, and 95.51% is obtained for Hepatitis dataset. The proposed framework can be tailored to develop clinical decision-making systems for any health disorders to assist physicians in clinical diagnosis.

A Generic-Driven Wrapper Embedded With Feature-Type-Aware Hybrid Bayesian Classifier for Breast Cancer Classification

Breast cancer is one of the most common cancers diagnosed in women. For preventive diagnosis, feature selection is an essential step to construct the breast cancer classifier. The features of a real breast cancer dataset are usually composed of discrete and continuous ones. Also, the Area Under the Curve (AUC) of the receiver operating characteristic receives more attention in such a medical field. The existing research work is insufficient to take into account both the hybrid trait of the features and the specific classification objective. We have proposed a wrapper method, i.e., a integrated framework in which Bayesian classifiers are embedded for the feature selection of breast cancer datasets. To deal with both the discrete features and the continuous features, we adopt the naive approach for the discrete features but the kernel probability density estimation for the continuous ones, respectively, which leads to feature-type-aware hybrid Bayesian classifiers. All the classifiers are fed with different feature subsets and evaluated by their AUC metrics as the fitness indexes. Thus, with the genetic algorithm, we can obtain a near optimal feature subset, which yields a good AUC metric with its corresponding classifiers. Moreover, the one-class F-score is used to help enhance the convergence of the algorithm. Experiments are done both with the continuous Wisconsin diagnostic breast cancer dataset and the real breast cancer dataset for Chinese women. The results prove that the proposed wrapper is feasible, accurate and efficient, compared with the related genetic algorithm based approaches.