A new wireless impact echo prototype was developed for the condition assessment of reinforced concrete slabs. The new system includes a wireless handheld sensing device which connects by Bluetooth to a tablet equipped with a user-friendly software for managing the testing grid, recording measurements, processing and transforming the data to a frequency domain, and presenting the results in real time. To validate the device, three large-scale concrete slabs of dimensions 2000 mm x 2000 mm x 300 mm were fabricated with artificial defects including voids, delamination, vertical cracks, and geometric discontinuities. The influence of slab boundaries, defect depth and location, overall thickness, steel reinforcement, and an internal conduit on the obtained measurements were investigated. The results were also compared with other commercial non-destructive testing devices including ground penetrating radar (GPR) and ultrasonic pulse velocity (UPE), and the advantages and disadvantages of each method are discussed. Overall, the results suggest that the impact echo technique using the new wireless prototype is able to accurately detect and characterise various defect types provided that the right size of impactor is used. Use of improper impactor sizes can result in alternative vibration modes depending on the slab thickness and defect depth; in that case, multiple readings may be required. The new system greatly improved the ease-of-use of the impact echo technique, although the inspector should be trained to properly interpret the results. Compared with the GPR technique, the impact echo system was not as rapid and unable to detect the location of steel reinforcement; on the other hand, it was better able to detect defects in the presence of steel bars which tended to obscure readings using GPR. UPE measurements were also faster than the impact echo tests and performed well for slab thickness measurements and detection of certain defect types; however, readings were found to be affected by the presence of steel reinforcement and in some cases were inconsistent. Overall, it may be concluded that each technique presents certain strengths and weaknesses that should be considered in the condition assessment strategy. The results obtained from each technique are complementary and may be used to develop a complete understanding of the internal state of the structure.