Purpose: Wireless devices have revolutionized the practice of medicine and the daily lives of physicians and patients alike, much as capsule endoscopy (CE) has revolutionized the location and treatment of occult GI bleeds. As, wireless technology progresses, so too does their need for stronger signal strength and need for broader frequency bandwidths and potential for causing interference with each other. Wireless devices have designated operating frequencies: CE operates at 434.09 Hz when communicating to the data recorder, while the four major cell phone carriers operate on a spread of two frequency ranges: AT&T (850/1900 Hz), Verizon (800/1900Hz), Sprint (900/2500Hz), and T-Mobile (1700/2100 Hz), laptop computer networks operate at 820.11 Hz, and pagers typically operate at 931.28 Hz. The purpose of this study was to investigate any clinically relevant electromagnetic interference between next generation cell phones (3G and 4G networks), wireless computer networks, and pagers with the CE. Methods: In vitro experiments were conducted in a specially-designed saline bath simulating the distances expected during concomitant use of these devices. A PillCam® (Given Imaging) was placed in the bath and a standardized text gradient was recorded continuously, downloaded, and evaluated. Individually each cell phone, laptop, and/or pager was placed 5-15 cm away from the Pillcam. Then, all 4 cell phones, the laptop computer, and pager were placed as near as possible to the Pillcam (5-25 cm) while it acquired images. The wireless devices were activated with a phone call or download for at least 1 minute each. Finally, a spectrum analyzer was used to ensure that ambient background in hospital electromagnetic interference could not influence results. Results: All devices performed according to specifications. Each cell phone completed at least one minute worth of call time without disconnection and the laptop computer did not have any significant disruption in download rate. The review of CE images showed no distortion. Conclusion: The prevalence of next generation cell phones, laptops, and pagers in the hospital setting, among patients and healthcare workers alike, makes it imperative that concomitant use of these devices is explored to ensure patient safety. No precautions are indicated for CE and current next generation cell phones, laptops, and pagers.