Wire drawing produced by extrusion process prevents tensile failures of wire, increases the production rate, reduces friction at die/billet interface, and enhances the surface finish and die life. The wire drawing of low strength ductile materials by direct extrusion process involves both the application of the extrusion pressure and the drawing force on the billet material. The lubricated zones (inlet zone, contact/work zone, and exit zone) formed at the interface of die and billet in the drawing process have significant influence on the quality of the finished product. An accurate analysis and determination of minimum film thickness in the inlet zone leads to the accurate modeling of the lubricating work zone. The grain refinement and strain hardening effects of material predominate in the work zone due to deformation of the billet. Thus, the accurate determination of friction stress in the work zone at die/billet interface in wire drawing process at various operating parameters is a vital issue. Therefore, the objective of this paper is to investigate friction stress at die/billet interface in the work zone in presence of three different lubricants (η0 =0.1, 0.2, and 0.3 Pa-s) considering lubricants’ starvation at different operating parameters using Lobatto quadrature technique in thermo-plasto-hydrodynamic analysis of interface. Based on the reported investigation, it is found that friction stress increases with increase in semi-die angle, material parameter, and lubricants’ viscosity.