Winter Meeting Research Articles

ENT trainee papers presented at the ENT Scotland Winter Meeting, 20 November 2015, Sterling, Scotland, UK

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Abstracts presented at the Winter Meeting of the British Association of Clinical Anatomists on 10th December 2015 at St. George's, University of London, Cranmer Terrace, London, United Kingdom

Questionnaires based studies of learning style/approach have influenced the design of modern medical curricula. Questions remain about the validity of these questionnaires across ever evolving student populations as approaches to learning almost inevitably change during medical school. This pilot study aims to identify differing learning approaches in first year medical students and determine a relationship with academic performance in an established curriculum designed to prepare for the United States Medical Licensing Examination. Fifty-one semester-I medical students participated in this study through completing the Approaches and Study Skills Inventory for Students (ASSIST) and the Dundee Ready Education Environment Measure (DREEM). DREEM scores showed a positive educational climate. Preferred approach to learning was 31%, 61%, and 8% for deep, strategic and surface approaches respectively. No significant difference was found between examination performance across students who adopted differing learning approaches. Performance correlated with both strategic (r=0.276, P<0.05) and surface learning approaches (r=-0.423, P<0.05). This study highlights the need to further investigate the efficacy of applying the results of questionnaires to curriculum design. Accounting for changes in student learning approach over the first year of medical school may be key in applying theory into practice.

What have we learned from immunotherapy? Report from the 3rd and 4th meetings of the Campania Society of Oncology Immunotherapy (SCITO)

Treatment strategies that target the immune system provide the opportunity for antitumor activity across multiple cancer types, regardless of mutational status or tumor histology. While many of the initial advances in immunotherapy have been in melanoma, the focus has now broadened to include many other solid as well as hematological cancers. Different immunotherapeutic approaches are being evaluated across tumor types and their various novel mechanisms of action and safety profiles offer the potential for a variety of combination regimens. Ongoing and planned investigation of these immunotherapies, alone and in combination, represents the start of a new chapter in our treatment of cancer and offers the hope of better outcomes for patients with a wide range of cancers. Recent advances in the use of immune-based approaches to treat non-small-cell lung cancer, breast cancer, ovarian cancer, gastrointestinal cancer, hepatocellular carcinoma, head and neck cancer and lymphoma were discussed at the 2015 Spring and Winter meetings of the Campania Society of Oncology Immunotherapy (SCITO) and are reported here.

‘Mind maps’: helping from pedagogy to packing

A straw poll at the recent Royal Society of Medicine Winter Meeting in Saalbach, Austria, showed that only a handful of delegates were aware of ‘mind maps’ – surprising given that an internet search will find millions of mind map images and articles. In this article the author describes the basic concept of mind maps and how they can be used by healthcare professionals in their work.

A brief history of topographical anatomy

This brief history of topographical anatomy begins with Egyptian medical papyri and the works known collectively as the Greco-Arabian canon, the time line then moves on to the excitement of discovery that characterised the Renaissance, the increasing regulatory and legislative frameworks introduced in the 18th and 19th centuries, and ends with a consideration of the impact of technology that epitomises the period from the late 19th century to the present day. This paper is based on a lecture I gave at the Winter Meeting of the Anatomical Society in Cambridge in December 2015, when I was awarded the Anatomical Society Medal.

THOUGHTS AND THEMES FROM THE 2016 ADFM WINTER MEETING

Are we Luddites? How can we “recalibrate”? What is a more pressing need in our Departments than producing outstanding family doctors? How can we bring joy back to clinical practice? These questions are a few among many that stimulated our thinking during ADFM’s 2016 Annual Winter meeting. A

2016 AAPT Award Citations at the Winter Meeting, New Orleans, LA

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Winter Meeting. Abstracts of the 205th Meeting of the Pathological Society of Great Britain & Ireland, 7-8 January 2016, London.

Winter Meeting. Abstracts of the 205th Meeting of the Pathological Society of Great Britain & Ireland, 7-8 January 2016, London.

Abstracts of the UK Molecular Epidemiology Group Winter Meeting on The Ageing World: employing molecular epidemiology to advance lifelong health. Newcastle University, Research Beehive, Newcastle upon Tyne, UK. December 1, 2015

Abstracts of the UK Molecular Epidemiology Group Winter Meeting on The Ageing World: employing molecular epidemiology to advance lifelong health. Newcastle University, Research Beehive, Newcastle upon Tyne, UK. December 1, 2015

Functions of decision support systems (JRodos as an example): overview and new features and products

Under the auspices of its Euratom Research Framework Programmes, the European Commission (EC) has supported the development of the RODOS (Real-time Online DecisiOn Support) system for off-site emergency management after nuclear accidents for more than a decade. Significant additional funds have been provided by many national research programmes, research institutes and industrial collaborators. In particular, the German Ministry of the Environment, Nature Conservation and Reactor Safety financially contributed to the project with an emphasis on early emergency response. The final result of these collaborative actions, the comprehensive RODOS system, can be applied generally within and across Europe. It can be used in national or regional nuclear emergency centres, provides coherent support at all stages of an accident, and includes the long-term management and restoration of contaminated areas. Within the NERIS-TP project, several model improvements have been developed, covering the worldwide applicability of the system, the coupling with the early notification system of the IAEA, improved countermeasure modelling and model adaptation for the new ICRP 103 recommendations. Several of these new tools were also integrated into the ARGOS system (Hoe S., Muller H., Gering F., Thykier-Nielsen S., Havskov Sorensen J. (2002) ARGOS 2001: A decision support system for nuclear emergencies. In: American Nuclear Society Transactions . Winter Meeting Vol. 87, pp. 574-579).

2014–2015 WINTER MEETING OF THE ASSOCIATION FOR SYMBOLIC LOGIC Henry B. Gonzalez Convention Center San Antonio, TX, USA January 12–13, 2015

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ENT trainee papers presented at the ENT Scotland Winter Meeting, 21 November 2014, Sterling, Scotland, UK

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Abstracts presented at the Winter Meeting of the British Association of Clinical Anatomists on 8th January 2015 at the Centre for Comparative and Clinical Anatomy, University of Bristol, Bristol, United Kingdom

Abstracts presented at the Winter Meeting of the British Association of Clinical Anatomists on 8^th January 2015 at the Centre for Comparative and Clinical Anatomy, University of Bristol, Bristol, United Kingdom

Forum on Antebellum American Protestantism

At the 2015 Winter Meeting of the American Society of Church History, the panel “Futures of the American Religious Past” examined two of the most provocative and influential recent analyses of antebellum American protestantism—Mark A. Noll's America's God and John Lardas Modern's Secularism in Antebellum America. In one sense, the pairing is odd. The two books appear drastically different, stylistically and methodologically. Modern's highly original monograph constructs a genealogy of antebellum American secularism, illuminating ways in which this cultural force haunted the historicity of American protestantism. His analysis interweaves the theoretical and discursive approaches of cultural studies and religious studies. Noll's book, on the other hand, constructs a more traditional, though deeply creative, history of protestant religious ideas, attentive to the agency of individual thinkers and institutions. Both books are brilliant, yet they exist at two opposite disciplinary poles in the study of American religions. Their juxtaposition embodies what Laurie Maffly-Kipp in her 2013 American Society of Church History Presidential Address called our “transitional moment” in American religious history, as theoretical developments of religious studies confront traditional church history paradigms.

Gaddum Memorial Lecture 2014: receptors as an evolving concept: from switches to biased microprocessors.

This review is based on the JR Vane Medal Lecture presented at the BPS Winter Meeting in December 2014 by T. Kenakin. A recording of the lecture is included as supporting information and can also be viewed online here: https://www.youtube.com/watch?v=xrP81AQ8l-8. Pharmacological models used to describe drug agonism and antagonism have evolved over the past 20 years from a parsimonious model describing single active and inactive receptor states to models of multiconformational receptor systems modified by ligand conformational selection. These latter models describe the observed, presently underexploited, pharmacological mechanism of ligand-directed biased signalling. Biased signals can be quantified with transduction coefficients (ΔΔLog(τ/KA) values), a scale grounded in the Black/Leff operational model; this enables the optimization of biased profiles through medicinal chemistry. The past decades have also brought the availability of new technologies to measure multiple functional effects mediated by seven transmembrane receptors. These have confirmed that drugs can have many efficacies, which may be collaterally linked, that is there is no linear sequence of activities required. In addition, new functional screening assays have introduced increasing numbers of allosteric ligands into drug discovery. These molecules are permissive (they do not necessarily preclude endogenous signalling in vivo); therefore, they may allow better fine tuning of pathological physiology. The permissive quality of allosteric ligands can also change the quality of endogenous signalling efficacy ('induced bias') as well as the quantity of signal; in this regard, indices related to ΔΔLog(τ/KA) values (namely ΔLog(αβ) values) can be used to quantify these effects for optimization in the drug discovery process. All of these added scales of drug activity will, hopefully, allow better targeting of candidate molecules towards therapies.

Group for Research In Pathology Education (GRIPE)—Leading the Way in Pathology Education: Bridging Basic and Clinical Sciences Strategies &amp; Scholarship, 44th Annual Winter Meeting, January 30th, 2015 Tallahassee, FL

Group for Research In Pathology Education (GRIPE)—Leading the Way in Pathology Education: Bridging Basic and Clinical Sciences Strategies &amp; Scholarship, 44th Annual Winter Meeting, January 30th, 2015 Tallahassee, FL

2014 WINTER MEETING OF THE ASSOCIATION FOR SYMBOLIC LOGIC Marriott Philadelphia Downtown Philadelphia, Pennsylvania December 28–30, 2014

2014 WINTER MEETING OF THE ASSOCIATION FOR SYMBOLIC LOGIC Marriott Philadelphia Downtown Philadelphia, Pennsylvania December 28–30, 2014

PC190. A Quality Improvement Project to Improve IVC Filter Retrieval

Poor retrieval rates for retrievable inferior vena cava filters (R-IVCFs) have been reported throughout the literature, with poor follow-up as common cause. In 2009, we reported a retrieval rate of 18% despite an initial follow-up rate of 85%. Use of a registry has been shown to improve retrieval rates. In May 2012, as a process improvement project for Accreditation Council for Graduate Medical Education (ACGME) requirements, the vascular surgery fellowship implemented a reiterative registry to track R-IVCFs placed at Walter Reed National Military Medical Center to improve retrieval rates. We reported the initial 6-month results for 28 patients at the 2013 Winter Meeting of the Vascular and Endovascular Surgery Society. Here we report the results after 32 months with a total of 115 patients. Patients receiving R-IVCF were entered into a registry. All patients were reviewed monthly using an electronic health record (EHR). When there were no longer indications for R-IVCF, the patient was scheduled for an outpatient appointment with a vascular surgeon and then retrieval. Rates of retrieval, technical success, dwell time, indication, complications, and demographics were calculated for filters placed between May 2012 and January 2015. A total of 115 R-IVCFs were placed between May 2012 and January 2015. Fifty filters were placed for therapeutic indications and 65 for prophylactic indications. Our follow-up rate improved to 95%. A total of 72 filters were retrieved (63% absolute retrieval rate). The average dwell time was 103 days (range, 7-460 days), and 62% were retrieved within 3 months of placement. Technical success for retrieval was 91%. There were two major complications from retrievals (2.5% of retrievals). The creation of R-IVCF registry promoted on-going follow-up with patients. In our earlier experience, retrieval rates were poor despite a high follow-up rate. The use of a reiterative registry improved our retrieval rate by 45% and increased our follow-up rate to 95%. These results emphasize the importance of repetitive follow-up for R-IVCF. Despite follow-up, nearly a third of R-IVCF are not retrieved.

2015 AAPT Award Citations at the Winter Meeting, San Diego, California

2015 AAPT Award Citations at the Winter Meeting, San Diego, California

Abstracts

s from the 38th Annual Winter Meeting of the Geological Society's Mineral Deposits Studies Group held on 18–19th December 2014 at the University of Southampton, UK. The meeting was organised by Dr Robert Knight from the University of Southampton.