Based on the potentiometric measurements average fluorine concentrations for different phases of the hydrological regime were determined in water samples taken in 2018-2020 in the outlet of the Ob River: 0,103 mg/L in the winter low-water period, 0,079 mg/L in the spring - summer flood, and 0,095 mg/L in the summer - autumn low-water period. The present-day weighted average concentration of fluorine in the Ob River water (0,086 mg/L) closely corresponds to the values measured in 1954-1956 and 1976-1980 (0,090 and 0,084 mg/L, respectively), therefore the fluorine content of 0,08-0,09 mg/L could be taken as a natural background.