Open Window Research Articles

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling

BackgroundLung metastasis is the most adverse clinical factor and remains the leading cause of osteosarcoma-related death. Deciphering the mechanisms driving metastatic spread is crucial for finding open therapeutic windows for successful organ-specific interventions that may halt or prevent lung metastasis.MethodsWe employed a mouse premetastatic lung-based multi-omics integrative approach combined with clinical features to uncover the specific changes that precede lung metastasis formation and identify novel molecular targets and biomarker of clinical utility that enable the design of novel therapeutic strategies.ResultsWe found that osteosarcoma-bearing mice or those preconditioned with the osteosarcoma cell secretome harbour profound lung structural alterations with airway damage, inflammation, neutrophil infiltration, and extracellular matrix remodelling with increased deposition of fibronectin and collagens by resident stromal activated fibroblasts, favouring the adhesion of disseminated tumour cells. Systemic-induced microenvironmental changes, supported by transcriptomic and histological data, promoted and accelerated lung metastasis formation. Comparative proteome profiling of the cell secretome and mouse plasma identified a large number of proteins involved in extracellular-matrix organization, cell-matrix adhesion, neutrophil degranulation, and cytokine-mediated signalling, consistent with the observed lung microenvironmental changes. Moreover, we identified EFEMP1, an extracellular matrix glycoprotein exclusively secreted by metastatic cells, in the plasma of mice bearing a primary tumour and in biopsy specimens from osteosarcoma patients with poorer overall survival. Depletion of EFEMP1 from the secretome prevents the formation of lung metastasis.ConclusionsIntegration of our data uncovers neutrophil infiltration and the functional contribution of stromal-activated fibroblasts in ECM remodelling for tumour cell attachment as early pro-metastatic events, which may hold therapeutic potential in preventing or slowing the metastatic spread. Moreover, we identified EFEMP1, a secreted glycoprotein, as a metastatic driver and a potential candidate prognostic biomarker for lung metastasis in osteosarcoma patients.Graphical abstractOsteosarcoma-derived secreted factors systemically reprogrammed the lung microenvironment and fostered a growth-permissive niche for incoming disseminated cells to survive and outgrow into overt metastasis.Daily administration of osteosarcoma cell secretome mimics the systemic release of tumour-secreted factors of a growing tumour in mice during PMN formation;Transcriptomic and histological analysis of premetastatic lungs revealed inflammatory-induced stromal fibroblast activation, neutrophil infiltration, and ECM remodelling as early onset pro-metastatic events;Proteome profiling identified EFEMP1, an extracellular secreted glycoprotein, as a potential predictive biomarker for lung metastasis and poor prognosis in osteosarcoma patients.Osteosarcoma patients with EFEMP1 expressing biopsies have a poorer overall survival.

Research Component: Day lighting Integration in Commercial Buildings

Day lighting is defined as the natural maximum light used in a commercial building to illuminate the interior space of the building. The strategy has numerous benefits including energy saving, enhancing interior space, and aesthetics in the structure. Daylighting can be achieved in commercial buildings by the orientation of building windows opening and the material used.

Asthma and Other Respiratory Diseases of Children in Relation to Personal Behavior, Household, Parental and Environmental Factors in West China.

Asthma and other respiratory diseases, which are of great concern in public health, are paid less attention in areas that are less economically developed. This research aimed to study the prevalence of critical respiratory diseases of children living in West China and figure out the potential influencing factors. A total of 575 children under the age of 14 were recruited from Xinjiang, China, to participate in the study in 2022. Information on activity patterns, socioeconomic and parental factors, and household and surrounding environment situations was obtained using a questionnaire survey. Logistic regression models were applied to estimate the odds ratios of respiratory disease prevalence in relation to behavior patterns, household, parental and environmental factors, respectively. The prevalence of ever doctor-diagnosed asthma, doctor-diagnosed bronchitis and current bronchitis were 4.7%, 19.0% and 14.4%, respectively. The prevalence of doctor-diagnosed pneumonia was 8.2%, which was two times higher in urban than rural areas. Longer annual heating duration was significantly associated with higher risks in children's asthma and bronchitis, with an odds ratio (OR) and 95% confidence interval (95% CI) of 3.363 (95% CI: 1.215-9.298) and 1.267 (95% CI: 1.002-1.601), respectively. Opening the window longer in autumn would lead to higher risks of bronchitis, with ORs of 1.165 and 1.133, respectively, for doctor-diagnosed bronchitis and current bronchitis. Residential air pollution and having a residence close to waste incineration plant or garbage station were, respectively, significantly associated with higher risks of doctor-diagnosed bronchitis and asthma. Parental disease history was associated with a higher prevalence of children's asthma and respiratory diseases, whereas breastfeeding and doing physical exercise were, respectively, significantly associated with a lower risk of asthma. A high prevalence of respiratory diseases in children in West China may be partly attributed to longer annual heating time, opening windows longer in autumn, surrounding environmental pollution, as well as parental disease history, whereas promoting physical activity and breastfeeding could be an effective measure to reduce the risk of childhood asthma in West China.

2330. Ventilation Strategies Based on an Aerodynamic Analysis During a Large-Scale SARS-CoV-2 Outbreak in an Acute-Care Hospital

Abstract Background The severity of coronavirus disease-2019 (COVID-19) has decreased owing to antiviral agents and herd immunity; however, transmission among hospitalised patients could be fatal. Therefore, strategies to prevent the spread of COVID-19 in medical institutions are crucial. This study aimed to investigate ventilation strategies to prevent nosocomial transmission of COVID-19. Methods We retrospectively conducted an epidemiological investigation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak between 12 February and 5 March 2021 in a referral teaching hospital in Korea. The pressure difference and air change per hour (ACH) of the rooms were measured in the largest outbreak ward. Airflow dynamics were measured based on the opening or closing of the outside window and door by using an oil droplet generator, indoor air quality sensor, and particle image velocimetry in the index patient’s room, corridor, and opposite rooms. Results During the outbreak, 283 COVID-19 cases were identified. The largest outbreak occurred at the 8th floor followed by the 9th and 7th floors of the main building. According to an epidemiological investigation, the SARS-CoV-2 spread occurred sequentially from the index room to the nearest room, especially the opposite. The aerodynamic study demonstrated that droplet-like particles in the index room diffused through the corridor and the opposite room through the opening door (Figure 1). The mean ACH of the rooms on the 8th floor was 1.44; the air supply volume was 15.9% larger than the exhaust volume, forming a positive pressure. Compared with the open-door condition, droplet-like particles did not diffuse into an adjacent room facing each other in the closed-door condition. The concentration of droplet-like particles in the ward was lowered during natural ventilation, and their spread to an adjacent room facing the corridor was also reduced (Figure 2). Location of the index patient and detection sensor of the droplet-like particles Relative ratio in measurement of droplet-like particles, PM2.5, concentration according to natural ventilation conditions (A) Window closed/indoor-open (usual condition: ventilation with the heating, ventilation, and air conditioning [HVAC] system without natural ventilation), (B) Window open/indoors closed (condition for improvement: close the door and perform natural ventilation for each room), (C) Window and indoor opening (condition for improvement: opening all doors and windows in all the rooms and maximising natural ventilation). Conclusion The spread of droplet-like particles between rooms could be attributed to the pressure difference between the rooms and corridor. To prevent the spread of transmission between rooms, increasing the ACH in the room by maximising natural and mechanical ventilation is essential. Disclosures All Authors: No reported disclosures

Influence of window opening on cyclic behavior of precast infill wall with sliding joints

Influence of window opening on cyclic behavior of precast infill wall with sliding joints

Sightings of the witch (Lepidoptera: Araotes lapithis) in Northeast Bangladesh

Biogeographically situated between the Indo-Malayan and Indo-Chinese subregions, Bangladesh is home to over 400 species of butterflies. Lacking sufficient surveys of butterflies, the distribution and occurrence of many species in the country are still not well known. Hence, reports on the sightings of any poorly known butterfly species may help to develop a baseline for designing precise research and open windows for conservation efforts. The global distribution of the witch (Araotes lapithis Moore, 1858) butterfly ranges throughout south and southeast Asia, including India, Bangladesh, Bhutan, Thailand, Malaysia, Cambodia, Myanmar, Philippines and Indonesia. There are few records of the species from different states of northeast India including Assam, Tripura, Nagaland, and West Bengal.

Adaptation behaviors modify the effects of body fat on heat-related symptoms among Taiwanese elderly

BackgroundThe aging process increases body fat and susceptibility to heat-related illnesses. The relationship between body composition and symptoms associated with exposure to extreme heat among the elderly is unclear. Additionally, the influence of individual adaptive behaviors in mitigating these risks has not been adequately explored. ObjectivesThis study aimed to evaluate the association between body composition and heat-related symptoms as well as the potential modifying effects of heat adaptation behavior. MethodsThe body composition of elderly individuals was measured using bioelectrical impedance analysis. Face-to-face interviews were conducted a year later to determine the heat-related symptoms and adaptive behaviors practiced for the extremely hot days of the previous year. The association between body composition indices and the presence of more than two symptoms was assessed using logistic regression analysis, while stratified analysis and interaction term in models were used to evaluate the effect modifications of adaptive behaviors. ResultsOf the 859 participants, 16% reported more than two heat-related symptoms. Increased body fat mass index (fat mass in kg/squared height in meters) was associated with an elevated risk of more heat-related symptoms (odds ratio 1.11, 95% confidence interval 1.02–1.20). Each combination of staying indoors, using an umbrella and hat, and using air conditioning at noon reduced the risk association between body fat and symptoms. For females, a combination of reducing physical activity and staying indoors provided similar protective effect. Surprisingly, bathing more frequently in hot weather with heated instead of non-heated water augmented the risk correlation. Neither fan usage nor window opening displayed protective effects. ConclusionsElevated body fat levels, indicative of obesity, corresponded with an increased risk of heat-related symptoms. Integrating multiple adaptive behaviors can diminish the negative health impact of body fat on heat-induced symptoms. However, certain commonly adopted practices might not confer expected benefits.

Vertical musculocutaneous trapezius flap for the closure of postpneumonectomy empyema.

The aim of the study was to present our experience with the vertical musculocutaneous trapezius (VMCT) flap and highlight its utility in the thoracic wall reconstruction in patients with bronchopleural fistula (BPF). We present a five case series of patients with long-standing cavities and BPF. The VMCT flap was used, and a direct pathway into the defect was made through a separate posterior thoracotomy shortening the distance between the flap and the defect. In 80% of the cases, the flap succeeded in solving the fistula and filling the defect, quality of life improved, and the need for oxygen decreased. Management of open window thoracostomy is challenging. Debridement, thoracoplasty, and flap coverage are the mainstream of their treatment, but these patients have scarce available muscle. The VMCT flap represents the major non-affected musculocutaneous unit in the thoracic area after lung surgery. Its dermal component offers a rigid matrix to form a seal over the bronchial stump. Its muscular component adds a good amount of vascularized tissue. No functional impairment has been described after its use.

Efficacy of 3D screens for sustainable mosquito control: a semi-field experimental hut evaluation in northeastern Tanzania

BackgroundA three-dimensional window screen (3D-Screen) has been developed to create a window double-screen trap (3D-WDST), effectively capturing and preventing the escape of mosquitoes. A 2015 laboratory study demonstrated the 3D-Screen's efficacy, capturing 92% of mosquitoes in a double-screen setup during wind tunnel assays. To further evaluate its effectiveness, phase II experimental hut trials were conducted in Muheza, Tanzania.MethodsThree experimental hut trials were carried out between 2016 and 2017. Trial I tested two versions of the 3D-WDST in huts with open or closed eaves, with one version using a single 3D-Screen and the other using two 3D-Screens. Trial II examined the 3D-WDST with two 3D-Screens in huts with or without baffles, while Trial III compared handmade and machine-made 3D structures. Mosquito capturing efficacy of the 3D-WDST was measured by comparing the number of mosquitoes collected in the test hut to a control hut with standard exit traps.ResultsTrial I showed that the 3D-WDST with two 3D-Screens used in huts with open eaves achieved the highest mosquito-capturing efficacy. This treatment captured 33.11% (CI 7.40–58.81) of female anophelines relative to the total collected in this hut (3D-WDST and room collections) and 27.27% (CI 4.23–50.31) of female anophelines relative to the total collected in the control hut (exit traps, room, and verandahs collections). In Trial II, the two 3D-Screens version of the 3D-WDST captured 70.32% (CI 56.87–83.77) and 51.07% (CI 21.72–80.41) of female anophelines in huts with and without baffles, respectively. Compared to the control hut, the capturing efficacy for female anophelines was 138.6% (37.23–239.9) and 42.41% (14.77–70.05) for huts with and without baffles, respectively. Trial III demonstrated similar performance between hand- and machine-made 3D structures.ConclusionsThe 3D-WDST proved effective in capturing malaria vectors under semi-field experimental hut conditions. Using 3D-Screens on both sides of the window openings was more effective than using a single-sided 3D-Screen. Additionally, both hand- and machine-made 3D structures exhibited equally effective performance, supporting the production of durable cones on an industrial scale for future large-scale studies evaluating the 3D-WDST at the community level.Graphical

Life cycle assessment (LCA) and energy assessment of the production and use of windows in residential buildings

There is an observable scarcity of comprehensive research results comparing the environmental damage associated with both the production of windows and their subsequent operation. The environmental impact of the operation of windows depends on their thermal insulation parameters, and thus the amount of heat that must be generated to heat the building. The type of heating system and, above all, the type of fuel used to generate heat are also not without significance. Unfortunately, in Poland, a significant proportion of single-family houses operate on the fossil fuel heating system, including on coal and fuel oil. It is therefore important to present an environmental balance sheet of both the production and operation of windows for different variants of building heating. The purpose of the study was to determine: to what extent the manufacturing of windows of different construction and different insulation parameters affects the environment, to what extent does the negative environmental impact of the process of manufacturing with greater insulation compensate by the lower environmental impact related to savings on fuel (gas, coal, fuel oil) used to generate heat during the operation of windows. Three types of windows were selected for a detailed analysis: a triple-glazed aluminum construction, a double-glazed PVC construction and a triple-glazed PVC. The research results show that in the case of all impact categories, the greater environmental losses related to the improvement of the thermal insulation parameters of the windows at the production stage are fully compensated at the stage of their useful life, regardless of the type of fuel used to heat the buildings. Double-glazed PVC windows should be phased out of production due to significant environmental footprint associated with their operation.

Does window/door opening behaviour during summer affect the bedroom environment and sleep quality in a high-density sub-tropical city

To investigate the effects of window and/or door opening on sleep quality, a two-week field intervention study was performed in 50 bedrooms in the summer in a high-density city (Shanghai). Each participant slept as they did normally in their own bedroom during the first week and changed the state of windows or doors from open to closed or vice versa in the second week. Their bedroom environment and sleep quality were objectively measured. Available data from 256 person-nights in which the intervention was effective were used for analysis of window or door manipulation. The indoor carbon dioxide (CO2) concentrations were lower and the air temperatures and PM2.5 concentrations were higher when windows were open. The perceived air freshness and noise intensity were both higher and the duration of REM-sleep (Rapid Eye Movement sleep) was lower in this condition. No significant differences were found in other sleep quality indexes. These results suggest that in a high-density city, the increased indoor temperature, PM2.5 concentration as well as noise caused by opening windows may disturb sleep and offset the positive effects of improving the ventilation. Thus, window opening should not be recommended as a universal way of achieving bedroom ventilation to promote sleep. Affordable retrofit solutions for bedroom ventilation should take these aspects into account.

High-density open window mapping vs conventional mapping in accessory pathways ablation

Abstract Background and purpose High density (HD) mapping is associated with a reduction in fluoroscopy time compared to conventional mapping in accessory pathway (AP) ablation. The Open Window (OW) technique (CARTO 3, Biosense Webster) is a new tool that automatically uses conventional electrophysiology criteria for AP location, as shorter local EGM AV interval (extended early meets late tool), earliest local activation time (LAT) and annotation at unipolar signal (wavefront annotation). However, no studies comparing its feasibility to conventional mapping have been conducted. Therefore, the aim of the present study was to assess the feasibility and the clinical implications of high-density OW mapping when compared to conventional HD mapping. Methods A prospective, unicentric cohort study was conducted that included consecutive patients which were referred to our institution for AP ablation with OW mapping technique and compared to a recent retrospective cohort of patients who underwent conventional HD mapping. Total fluoroscopy time, total mapping time and the rate of recurrence of the AP were compared between groups. A schematic step by step graphic of the workflow procedure is represented in figure 1. Results A total of 33 consecutive patients (32.28 ± 18 years, 58% males) were included in the OW group and compared with a cohort of 29 patients (29.6 ± 18 years, 52% males) who underwent conventional HD mapping. An example of Right Superior AP ablation is showed in figure 2. No differences in the location of the AP were observed (p=NS). OW mapping was associated to a lower mapping time (29.3 vs 37.8 min; p=0.04), lower fluoroscopy time (14.3 vs 21.3 min; p= 0.04) and lower radiofrequency time (p=0.007). After a median follow up of6 months, there were no differences in the rate of recurrence of the AP conduction between groups (p=NS). Conclusions In our experience, OW mapping was a feasible tool for AP location associated to a lower mapping time, lower radiofrequency time and lower X-ray exposure time with no differences in recurrence rate when compared to conventional HD mapping. However, more studies should be performed to corroborate these conclusions.Step by Step WorkflowRight Superior AP ablation

ЙМОВІРНИЙ ВИГЛЯД ДАВНЬОРУСЬКОГО ХРАМУ СВ. ПЕТРА У ПЕРЕМИШЛІ ЗА МАТЕРІАЛАМИ АРХЕОЛОГІЧНИХ ДОСЛІДЖЕНЬ 2015 – 2017 РОКІВ

Based on archaeological research conducted between 2015 and 2017, along with a comparative analysis of related examples of sacred structures from the Rurik period in Halicia and the local traditional architecture, a hypothesis has been formulated regarding the possible design of the ancient Rus’ church of St. Peter inPeremyshl (Przemyśl), which is believed to have existed from the 12th to the early 15th century. Drawing on the presence of a relatively narrow foundation, a parallel was drawn to the quadrifolium "Polygon" in Halych, which is likely to have featured a combination of brick walls and wooden upper part in its architecture. The suggested reconstruction of the ancient Rus` church of St. Peter in Peremyshl (Przemyśl) envisions a stone masonry segment with a limited number of window openings situated in the transept's side walls and the central apse. A carved stone bas-relief was probably located above the entrance on the western facade, with historical accounts supporting this notion. Although the bas-relief once attributed to this church within the Old City was later identified as a product of subsequent folk art, it does provide evidence that the memory of the St. Peter church persists with stone architectural elements. The restoration of the upper portion of the structure appears relatively straightforward due to the availability of a vast array of materials from similar structures. Many of these materials have been preserved and offer insights into construction methods and finishing techniques. The use of shingle covering on vertical walls helps maintain load-bearing components, which are best not replaced in the sacred building due to the tradition of religious paintings that adorned much of the interior space.

Elemen Fasad Bangunan Pembentuk Karakter Koridor Jalan Ahmad Yani Garut Berdasar Preferensi Masyarakat

<p><em>The corridor of Jalan Ahmad Yani, as the main street of Garut Regency, is part of Garut Heritage sites. As a historical place, the area’s character becomes an important part. This study aims to find the building facade elements that formed the character of the Jalan Ahmad Yani corridor. Quantitative method with Conjoint is used to analyze and interpret data. Respondents consist of 20 architects that live in Garut. Massing shape, roof shape, walls, door and window openings, ornaments or billboards, texture, and color are the variables studied. The study found that the facade elements that are considered important in forming the character of the corridor, are geometric shapes, triangular roof shapes, mixed walls of solid and transparent, smooth textured, and calm colors, the shape of window openings pointing vertically and doors that balanced in the façade composition, and ornaments or billboards as part of the building façade composition.</em></p>

Mechanical performance of prefabricated lightweight steel-foamed ceramsite concrete wall panels: Experimental and theoretical investigations

Prefabricated construction garnered significant attention in recent years. As a vital component, the performance of wall panels played a crucial role in the overall construction, necessitating focused attention. This paper presented experimental and theoretical investigations into the mechanical performance of prefabricated lightweight steel-foamed ceramsite concrete wall panels. Static and cyclic load tests were initially conducted, considering various shapes and the presence of window opening. Subsequently, finite element (FE) simulations and theoretical investigations were carried out to assess the compressive performance of the wall panels. Furthermore, a prototype house was constructed to evaluate the constructability of the proposed system. The results demonstrated that the proposed wall panels exhibited excellent compressive and seismic performance. The FE models can accurately simulate the failure modes and load-deflection relationships of different wall configurations. Additionally, a modified model was proposed to assess the ultimate load of multi-shaped composite wall panels based on the conventional code, and the calculated values agreed well with experimental results. Moreover, the structural analysis results of the prototype house confirmed that all structural parameters met the design code requirements, showcasing the practicality and reliability of the proposed system.

Development of a Machine Learning Framework Based on Occupant-Related Parameters to Predict Residential Electricity Consumption in the Hot and Humid Climate

Occupant-related variables constitute one of the most significant groups of factors influencing residential building energy consumption. However, prediction methods often oversimplify these parameters, leading to substantial discrepancies between predicted and actual consumption. To address this issue, the present study aims to develop a machine learning framework for predicting electricity consumption in residential buildings based on occupant-related factors. The study incorporates twenty-six inputs, including occupant characteristics such as demographics, occupancy, behavior, and behavioral efficiency, two time-related factors, and three extra parameters related to equipment (refrigerator age, hot water source, and type of electricity meter) for training and testing the Random Forest (RF) algorithm in both regression and classification forms. The results indicate that the trained RF regressor exhibits well performance (R2Train = 0.989, R2Test = 0.916, MAETrain = 0.81, MAETest = 2.21, RMSETrain = 1.27, and RMSETest = 3.45). Furthermore, feature importance analysis reveals that the most significant parameter is the time of year, representing weather conditions, followed by the number of occupants, neighborhood, indoor set-point range, mean age of occupants, window opening, and cooling system mode. Even after removing the least impactful factors, the model maintains strong performance with the 16 most important variables (R2Train = 0.986, R2Test = 0.910, MAETrain = 0.83, MAETest = 2.25, RMSETrain = 1.31, and RMSETest = 3.49). Additionally, the RF classifier is designed for problems with 2, 4, 6, and 8 classes based on energy consumption ranges. The results of this model demonstrate that the 2-class model achieves the highest performance (AccuracyTest = 0.963, MAETest = 0.04, and RMSETest = 0.19). However, it lacks detailed categorization of homes based on electricity consumption. On the other hand, the 4-class and 6-class models strike a good balance between prediction performance and the level of detail. In conclusion, the proposed method can accurately predict residential electricity consumption and can serve as a valuable reference for researchers and utility managers when formulating energy reduction policies and comparing the effectiveness of different strategies.

MOF-808 as an Efficient Catalyst for Valorization of Biodiesel Waste Production: Glycerol Acetalization.

Glycerol is the main residue in the biodiesel production industry; therefore, their valorization is crucial. The acetalization of glycerol toward fuel additives such as solketal (2,2-dimethyl-1,3-dioxolan-4-methanol) is of high interest, promoting circular economy since it can be added to biodiesel or even fossil diesel to improve their quality and efficiency. Straightforward-prepared metal-organic framework (MOF) materials of the MOF-808 family were applied to the valorization of glycerol for the first time. In particular, MOF-808(Hf) was revealed to be an effective heterogeneous catalyst to produce solketal under moderate conditions: a small amount of the MOF material (only 4 wt% of glycerol), a 1:6 ratio of glycerol/acetone, and a temperature of 333 K. The high efficiency of MOF-808(Hf) was associated with the high amount of acid centers present in its structure. Furthermore, its structural characteristics, such as window opening cavity size and pore diameters, were shown to be ideal for reusing this material for at least ten consecutive reaction cycles without losing activity (conversion > 90% and selectivity > 98%). Remarkably, it was not necessary to wash or activate the MOF-808(Hf) catalyst between cycles (no pore blockage occurred), and it maintained structural integrity after ten cycles, confirming its ability to be a sustainable heterogeneous catalyst for glycerol valorization.

Millennial’s Residential Design Principle & Basic Model To Improve Work- from-Home Performance Through Mindfulness Practices

Since the pandemic COVID-19 outbreak in 2020, it appears that the entire world has been forced to become acquainted with working from home as a new working concept. One of the dominant challenge in implementing work-from-home comes from decline of work performance caused by incapability to cognitively focus on several task at once. Millennial as a dominant productive age range in Indonesia are facing this continuously emerging problems, considering work-from-home working culture and flexible working are believed to be a future of work culture. When implementing work-from-home, millennials face the challenge to improve work performance, one of which is through mindfulness practices to help boost work performance. Through a literature review and design by research, this study seeks to identify a home and workspace design application model that accommodates mindfulness practices. Mindfulness practices are accommodated through flexible spatial planning, building materials with various texture, window openings in the workspace are strategically adjacent to green garden, green spaces with wide variety of colour, shape, and textures, and then the principle are applied in a residential models that fit the preferences for the millennial generation

Re-purposed drive-through vaccination set-up for Mpox, New York Metropolitan Area

This report details how one large medical center in the Metropolitan New York area re-purposed a drive-through COVID-19 vaccination structure to handle a surge in Mpox cases in July 2022.Methods/Results: Simultaneous to on-going COVID -19 vaccination and testing, Mpox vaccination was rolled out in the same drive through structure. More than 1,820 Jynneos (Smallpox and Monkeypox Vaccine, Live, Non-replicating) vaccine dosages were delivered subcutaneously and then intradermally to 1,123 individuals through the open window of their vehicles, averaging 8-10 patients an hour. Five vaccine recipients suffered Mpox rash; there was no exposure among healthcare providers. Drive-through vaccination is an efficient model to be redeployed for future unexpected vaccine initiatives.

Cupid stealing visual attention - the restoration of Vermeer's "Girl Reading a Letter at an Open Window" altered viewing behavior.

A major restoration of Vermeer's "Girl Reading a Letter at an Open Window" revealed a painting of cupid on the back wall that had been overpainted. The uncovering of this painting within a painting changed the composition of the artwork. We performed an eye tracking study on digital representations of the painting to investigate how the restoration altered the way people perceive this artwork. We show that the painting of cupid draws visual attention from the letter and that viewing behavior depends on knowledge of the other version of the painting. Moreover, lay people prefer the version without cupid.