As a result of wind power’s expansion over the globe, offshore wind turbines (OWTs) are being projected in seismic prone areas. In parallel, the industry develops increasingly larger and more powerful generators. Many of the seismic response analyses of wind turbines conducted so far only consider smaller units. In this paper, a finite element substructuring model in frequency domain is used to compute the seismic response of four reference OWTs from 5 to 15 MW founded on monopiles embedded in several homogeneous soil profiles with shear wave velocities from 100 to 300 m/s and subjected to different accelerograms. The foundation behaviour is obtained through a continuum model including kinematic and inertial interaction. The relevance of soil-structure interaction and main trends of the seismic response of OWTs are inferred from the presented results. Although the seismic maximum bending moments increase with the size of the OWT system, their relevance with respect to the ones produced by design loads decreases as the turbine gets bigger. The same effect is observed for the shear forces if the soil is soft enough. The inclusion of SSI effects almost duplicates the seismic response when compared to the rigid base scenario.