This study focuses on investigating the seismic performance of a reference 15 MW offshore wind turbine (OWT) supported by a large-diameter monopile, under various scour conditions. Fully coupled nonlinear finite element models considering 3D soil continuum for seismic response analysis of monopile-supported OWTs are very complicated and computationally expensive. Therefore, it is important to have good insight on the dynamic behaviour of monopile-supported OWTs subjected to earthquake excitations before performing high-fidelity fully nonlinear 3D simulations, which will not generally be practical in cases considering various seismic loading and scouring scenarios. The purpose of this study is to provide a fast and efficient tool to understand the interaction between the seismic behaviour of emerging large-capacity OWTs when scour erosion affects the dynamic properties of the structure. The dynamic stiffness method (DSM) is applied for the free vibration analysis of the structure. Modal superposition is used to calculate the seismic responses of the OWT by using the exact mode shapes obtained from the dynamic stiffness formulations. The rotor-nacelle-assembly (RNA) is idealized as a lumped mass at the tower top. The tower and monopile are modelled as Timoshenko beam-columns under axial compressive loading. The soil-structure interaction (SSI) is modelled using the Winkler framework, whereby the soil contribution is assumed as elastic to take advantage of the modal superposition method. Two different approaches are considered for the soil stiffness; a constant profile, and a linearly-varying subgrade modulus along the embedded depth of the pile, and both are appraised in this paper. Firstly, natural frequencies obtained from dynamic stiffness formulations are validated using experimental data from literature for the case of controlled dynamic SSI experiments, and for operating OWTs. Additionally, the natural frequency provided by a technical document for the reference 15 MW OWT is compared to the result from the DSM, where a very good agreement is observed. The seismic response time-histories of the OWT model are obtained under different input earthquake conditions, and subsequently verified by comparison with the results of finite element simulations. The effects of different scour scenarios and foundation modelling approaches on the free vibration and seismic responses are subsequently investigated. A parametric analysis is also performed using different soil properties to observe the interaction between the soil stiffness, scour condition, and seismic response. Finally, the influence of the frequency content of seismic records on the dynamic response of the OWT, specifically the tower top acceleration, the mudline rotation, and the mudline stress, is investigated considering various scour scenarios. The specific numerical case study undertaken for a reference 15 MW OWT, which is supported by a large monopile in very dense sand, shows that the seismic responses are very limited and that the elastic soil behaviour assumption is reasonable. Additionally, considering the computational efficiency, the proposed combination of DSM and modal superposition can be used for rapid seismic performance assessment of large diameter monopile-supported OWTs at the preliminary design stage to gain insight to the global dynamic response of the whole vibrating system.