Abstract Wind energy plays a pivotal role in the global effort to mitigate climate change, with China emerging as a leader in renewable energy adoption. The Hami region in northwestern China stands out as a crucial area for wind power development, given its substantial wind resources and strategic importance in China’s energy landscape. However, existing studies on wind energy potential vary widely and involve large uncertainties due to sparse measurements and coarse resolution, highlighting the need for more precise assessments to guide policy decisions and optimize energy utilization. This study leverages high-resolution ERA5 reanalysis data and advanced wind turbine technology to assess wind energy potential in the Hami region, taking into account factors including wind speed patterns, turbine heights, and geographical constraints. The comparison with in-situ data demonstrated that high-resolution ERA5 reanalyzed wind speeds enable to capture multi-year wind speed variations in this region. We find substantial potential for wind energy in Hami, with energy densities exceeding 200 W/m² in the high-potential wind zones. Importantly, this study identifies a new high-potential area in eastern Hami, termed the East Wind Zone. Our high-resolution assessment of wind energy potential at different heights over the past two decades reveals long-term trends and seasonal variations. Increasing the hub height from 95 m to 140 m raises the average wind power generation potential across Hami by 31.3 GWh/year. Our findings highlight the importance of strategic wind farm placement to maximize renewable energy output and provide insights for policy and industry, supporting China's renewable energy goals.