Future climatic change and sea-level rise threaten the persistence of reef islands potentially making them uninhabitable over the next century. Improved understanding of island morphodynamics at multiple time scales is required for resolving major drivers of shoreline change and predicting future island resilience. Utilising 45 individually mapped shorelines, the morphodynamic change of a shelf-edge reef island (Raine Island, Great Barrier Reef) has been quantified over a 57-year time scale in the context of environmental change and anthropogenic impacts. Results show that between 1963 and 2020, there has been an average net shoreline movement (NSM) of −4.71 m and an average rate of retreat of −0.11 m/yr. However, only 23% of the shoreline has exhibited statistically significant erosion while the remaining 77% has remained stable. Importantly, data reveal a remarkable level of long-term shoreline stability despite large seasonal fluctuations in wind and wave climate, episodic storm events, and a regional sea level rise currently outpacing the global mean. Direct human impact, through modifications of the beach profile since 2014, have resulted in localised increases in rates of shoreline change but have only slightly decreased the proportion of stable shoreline (91% since modifications commenced versus 96% prior to modifications). Interestingly, there is a significant decreasing trend in island planform area over the 57-year period and especially over the last decade. However, the length of the observation interval between sampled shorelines has a strong effect on the change in planform area recorded over the interval, suggesting increased sampling frequency, rather than sea level rise, is a more likely cause of the decreasing trend. The findings of this study have direct implications for more accurate assessments of past, present and future shoreline change on reef islands. They also support the concept of 21st century island persistence in the face of climate change although the relative resilience of a given island to change (e.g., sea level, human modifications) will depend on a continuous adequate supply of sediment from organisms living on the surrounding reef, which may or may not be threatened in the future.