Simulation models are useful tools for estimating plant response and contributing to the development of management strategies and yield predictions in crops. This study aimed to calibrate and evaluate the AquaCrop-FAO model for the forage cactus imposed on different cropping systems in the semi-arid region of Brazil. Four experiments were conducted: cactus-sorghum intercropping system with five spacings between plants (0.10, 0.20, 0.30, 0.40 and 0.50 m); cactus-sorghum intercropping system with five spacings between rows (1.00, 1.25, 1.50 and 1.75 m); single cactus with four levels of mulch (0, 5, 10 and 15 Mg ha−1); and single forage cactus with four levels of nitrogen fertilisation (50, 150, 300 and 450 kg of N ha−1). The performance of the model was evaluated using the following parameters: root mean squared error (RMSE); normalised RMSE (NRMSE), coefficients of determination (R2), Nash-Sutcliffe model efficiency coefficient (ME) and the Willmott index of agreement (d). During the calibration stage, the statistical indices pointed to the good performance of the AquaCrop model in estimating dry biomass in most of the cropping systems, with 10 < NRMSE <20; R2 > 0.96 and ME > 0.95. The AquaCrop model showed the best performance simulating systems under different levels of nitrogen fertilisation. Among the intercropping systems, the denser arrangements showed the highest values for simulated biomass.