ABSTRACT In Oregon's Willamette River, methylmercury levels in fish triggered health advisories and the need for a mercury Total Maximum Daily Load (TMDL). A translator was used to relate surface water total mercury (CTHg) to dissolved methylmercury concentrations (CDMeHg). The USEPA's Spreadsheet-based Ecological Risk Assessment for the Fate of Mercury (SERAFM) was used to elucidate the annual relationship between mercury loads, CTHg, and CDMeHg, to investigate whether CTHg is a reasonable predictor for CDMeHg, and to consider how load reductions may be affected by the differing annual trajectories of total and methylmercury concentrations. Modeling and observations suggest that CTHg and CDMeHg are not directly proportional, that CTHg is an inconsistent predictor of CDMeHg, that a single point estimate translator could easily misjudge their relationship, and that CDMeHg may be more responsive to environmental factors than to load alone. While a translator is convenient for relating CTHg and CDMeHg for regulatory purposes, it may not, due to environmental factors unrelated to loading, be the most efficacious means for this purpose. TMDLs relying on a translator are advised to conduct co-located total and methylmercury sampling with sufficient frequency to provide information on the watershed-specific annual relationship between total mercury and methylmercury.