To reduce the resistance of the ship in actual navigation, a hull form optimization design method for minimum wave resistance is proposed. A numerical wave tank of regular waves is established based on the CFD (Computational Fluid Dynamics) theory. Overlapping grid technology is adopted to mesh the hull form and free surface. The new hull offsets are generated by using the parameters of modified function as design variables. The geometric expression and reconstruction of optimized hull form is determined through the three-dimensional CAD (Computer Aided Design) modeling technology. The displacement limit was used as the basic constraint, and other additional constraints were considered; nonlinear programming quadratic line search algorithm was used to set up a mathematical model of hull form optimization on the ISIGHT platform. The optimization calculations of Wigley hull form and surface ship DTMB5415 are carried out. Compared with the parent hull, the wave resistance of the optimized hull form is significantly reduced, and the feasibility of this method is confirmed. The research results can provide technical support for the development of "green ship"design.