Whole Blood Bags Research Articles

Pengaruh waktu simpan Packed Red Cells (PRC) terhadap perubahan kadar hemoglobin, hematokrit, dan glukosa plasma di RSUP H. Adam Malik, Medan, Indonesia

Background: Someone who approves the PRC must have been transfused no more than 24 hours after the creation of the PRC; some also apply 3 days. But there are also those that apply up to 1 week. PRC is still feasible to be transfused immediately by seeing changes that occur in the value of hemoglobin (Hb), hematocrit (Ht), and plasma needed when storing.Methods: 30 whole blood bags (WB) were taken for this study. The WB is at the request of the doctor for the manufacture of PRC. The blood bag is rotated at a speed of 4,000 RPM for 15 minutes. From the PRC, 3 cc of blood was taken on 1,3,5,7 days for hemoglobin (Hb), hematocrit (Ht), and glucose plasma. Data were analyzed using SPSS version 21 software for Windows.Results: After 1-day taking 3 cc of blood, PRC was stored at 4 ° C, and then 3cc was taken also on days 3, 5, 7. The results showed that hemoglobin (Hb), hematocrit (Ht) increased from day 1 until day 7 but not significant (P> 0.05), plasma plasma showed a decrease from day 1 to day 7 and significant (P <0.001) but the value was still within normal limits. Correlation value between Hb and PRC retention time; r = 0.127, Ht with the shelf life of PRC, r = 0.160, plasma glucose with the length of time the PRC is stored; r = -0,844.Conclusion: PRC stored for 7 days is still feasible to use. There was a decrease in plasma glucose but still within normal limits.

Efficacy in reducing potassium load in irradiated red cell bags with a potassium adsorption filter

The transfusion of red cell (RBC) bags with high amounts of potassium (K(+)) causes concern about an increased risk of cardiac arrest because of transient hyperkalemia. To prevent K(+) overload, a K(+) adsorption filter (PAF) is available for use at bedside. The aim of the present study was to analyze the efficacy in reducing K(+) load in irradiated RBC bags with this PAF. Whole-blood (WB) bags were collected from volunteer donors on Day 0. RBC bags were prepared from WB bags on Day +1 and stored at 2 to 6 degrees C. RBC bags were irradiated on Day +14 and filtered with the PAF on Day +28, according to the manufacturers' instructions. The plasma electrolyte levels (Na(+), K(+), Cl(-), Ca(2+), and Mg(2+)) were measured at the different points during storage. Twelve RBC bags were prepared with a final volume of 274 +/- 15 mL. On Day +28, the volume of RBC bags was 257 +/- 15 mL, and the PAF was used at a flow rate of 4 +/- 0.7 mL per minute. K(+) level after RBC bag preparation was 1.28 +/- 0.59 mmol per L. The K(+) level was 60.6 +/- 2.68 mmol per L on Day +28, just before filtration with the PAF. After filtration, the level of K(+) was 3.42 +/- 2.91 mmol per L. This study has shown a high efficacy in reducing potassium load in irradiated RBC bags with the use of the PAF.