Abstract
Background: Someone who approves the PRC must have been transfused no more than 24 hours after the creation of the PRC; some also apply 3 days. But there are also those that apply up to 1 week. PRC is still feasible to be transfused immediately by seeing changes that occur in the value of hemoglobin (Hb), hematocrit (Ht), and plasma needed when storing.Methods: 30 whole blood bags (WB) were taken for this study. The WB is at the request of the doctor for the manufacture of PRC. The blood bag is rotated at a speed of 4,000 RPM for 15 minutes. From the PRC, 3 cc of blood was taken on 1,3,5,7 days for hemoglobin (Hb), hematocrit (Ht), and glucose plasma. Data were analyzed using SPSS version 21 software for Windows.Results: After 1-day taking 3 cc of blood, PRC was stored at 4 ° C, and then 3cc was taken also on days 3, 5, 7. The results showed that hemoglobin (Hb), hematocrit (Ht) increased from day 1 until day 7 but not significant (P> 0.05), plasma plasma showed a decrease from day 1 to day 7 and significant (P <0.001) but the value was still within normal limits. Correlation value between Hb and PRC retention time; r = 0.127, Ht with the shelf life of PRC, r = 0.160, plasma glucose with the length of time the PRC is stored; r = -0,844.Conclusion: PRC stored for 7 days is still feasible to use. There was a decrease in plasma glucose but still within normal limits.
Highlights
Someone who approves the Packed Red Cells (PRC) must have been transfused no more than 24 hours after the creation of the PRC; some apply 3 days
The results showed that hemoglobin (Hb), hematocrit (Ht) increased from day 1 until day 7 but not significant (P> 0.05), plasma plasma showed a decrease from day 1 to day 7 and significant (P
Red blood cell hemolysis during blood bank storage: using national quality management data to answer basic scientific questions
Summary
0.168 0.081 0.05). Pada Gambar 1 dapat dilihat bahwa perubahan kadar hemoglobin terhadap waktu simpan PRC menunjukkan adanya fluktuasi nilai hemoglobin selama penyimpanan 7 hari. Berkaitan dengan hal tersebut maka selanjutnya dilakukan analisis korelasi Spearman untuk melihat arah dan besarnya derajat hubungan, maupun kebermaknaan dari perubahan hemoglobin, hematokrit, dan plasma glukosa terhadap waktu simpan PRC seperti yang tercantum pada Tabel 2. Penelitian yang dilakukan oleh Karon dkk., Dan Spinelli dkk., Amerika Serikat membuktikan bahwa peningkatan kadar Hb dan F2α-isoprostan bebas terjadi selama penyimpanan PRC.[12,13] Peningkatan ini diperkirakan menjadi faktor yang menyebabkan hasil yang buruk pada penerima transfusi PRC meskipun mekanisme yang mendasari tidak sepenuhnya diketahui.[12,13]
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