World Health Organization Quality Of Life-BREF Research Articles

Nutrition Care Processes Can Improve the Nutritional Status and Quality of Life of Persons Who Use Drugs

Background:: Addiction affects the economy of countries worldwide. Nutrition plays an important role in helping persons who use drugs (PWUDs) to regain their physical and mental health, thereby increasing the probability of recovery. Objectives:: This study aimed to evaluate the effects of implementing the nutrition care process on PWUDs management 120 days after its implementation. Patients and Methods:: Following a quasi-experimental design with pre and post-test evaluations, 268 PWUDs admitted to 8 drug treatment, and rehabilitation centers in the Philippines were recruited. Developed nutrition management guidelines containing the nutrition care process and cycle menu of calculated diet for PWUDs were provided for implementation in the rehabilitation regimen. Body mass index was used to assess nutritional status, dietary diversity score (DDS) to measure diet quality, WHO quality of life-BREF to assess the quality of life (QoL), Kessler-10 Psychological Distress Scale to determine psychological distress, and Beck’s depression inventory to assess stress level. All descriptive analyses were performed using STATA version 13. Repeated measures ANOVA, Cochran’s Q test, and Kendall’s tau coefficient were performed using SPSS-20. Results:: The results indicated a 92% reduction in underweight during the study period. Participants with high DDS significantly increased from 38.43 to 91.04%. All domains of the QoL were improved, the level of severe depression was significantly decreased (6.72 to 4.48%), and decrease in the proportion of participants experiencing moderate (18.3 to 12.7%) and severe psychological distress (4.48 to 3.73%) was observed. There was no significant association between DDS and the three psychological parameters. Conclusions:: The implementation of the nutrition care process and the recovery diets is feasible and could improve the nutritional status, QoL, and stress level of PWUDs.

A comparative study of quality of life of patients with maxillofacial fracture and healthy controls at two tertiary healthcare institutions.

ObjectivesDespite treatment, the pre-traumatic facial appearance of patients with maxillofacial fractures might not be able to be restored, and this difference can affect the person’s quality of life (QoL). This study was designed to evaluate changes in QoL of people with maxillofacial fractures.Materials and MethodsThe study population was comprised of participants with maxillofacial fracture and age- and sex-matched healthy controls without history of such fracture. QoL was measured using the World Health Organization Quality of Life BREF (WHOQOL-BREF) questionnaire, which was administered to the patients before treatment (Time 1), at 6 weeks post-treatment (Time 2), and at 12 weeks postoperatively (Time 3). The values were compared with those of healthy controls. The QoL was compared between closed reduction group and open reduction and internal fixation group.ResultsThe QoL scores of people with maxillofacial fracture before treatment were significantly lower (P=0.001) than those of healthy controls in all domains of the WHOQOL-BREF. The QoL scores in the psychological and social domains of patients with maxillofacial fracture at Time 3 were still lower than those of healthy controls (P=0.001).ConclusionThe QoL of patients with maxillofacial fracture was significantly reduced before treatment in all domains and remained reduced in both psychological and social domains weeks after treatment. Therefore, clinicians must be aware of and manage the residual psychosocial issues that can accompany the post-treatment period of maxillofacial injury.

Who will guard the guardians? Cross-sectional study on prevalence of psychiatric morbidity, quality of life, and coping skills in caregivers of children with thalassemia major.

Background:Patients of thalassemia major require frequent hospitalization. Caregivers are more affected than the patient themselves as they better appreciate the magnitude of illness and treatment, resulting in increased risks for psychiatric illness.Aims and Objectives:The purpose of the study was to assess the prevalence of psychiatric morbidity in the caregivers of patients with thalassemia major. The study also examined the quality of life of the caregivers, their coping strategies, and its association with sociodemographic variables.Methodology:A cross-sectional study with 100 caregivers, recruited by convenience sampling technique, attending the thalassemia daycare center, was carried out over 12 months in a tertiary care hospital. They were administered a semistructured proforma along with General Health Questionnaire 12 (GHQ 12), WHO-Quality of Life-BREF (WHO-QOL-BREF), and Coping Inventory for Stressful Situations 21 scale. The GHQ 12 was used for screening and those scoring three or more underwent a clinical psychiatric interview. Those who were diagnosed with psychopathology were ascribed diagnosis as per ICD-10. Descriptive analysis was done. Associations were studied using Fischer's exact test. Comparison of quality of life with blood transfusion variables was done using Mann–Whitney U test.Results:The prevalence of psychiatric morbidity amongst the caregivers was found to be 35% with depressive episode (22%) being the most common. Psychiatric morbidity was found to have a significant association with both, the frequency (P = 0.037) and total number of blood transfusions (P = 0.012). Coping was found to have a strong association with psychiatric morbidity (P = 0.001) and employment (P = 0.009).Conclusions:Caregivers of children with thalassemia major face psychological burden like depression or anxiety, for which treatment is not sought. Improved psychological health of the caregivers will ensure better care of the child and guarantee better adherence to the treatment.

Quality of Life and Temporomandibular Disorders in Patients With Skeletal Class III Malocclusion With Cleft Lip and Palate.

The aim of the study was to assess the quality of life (QOL), oral health-related QOL (OHRQOL), temporomandibular disorders (TMDs), and psychological factors in patients with skeletal Class III malocclusion with cleft lip and palate (CLP) and without CLP. Case-control. Primary care, institutional practice. One hundred thirty-six patients with skeletal Class III malocclusion with CLP (n = 68) and without CLP (n = 68). QOL and OHRQOL were assessed using the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire and the Oral Health Impact Profile-14 questionnaire, respectively. TMDs and psychological factors were assessed using the Research Diagnostic Criteria for TMD (RDC/TMD). No differences in QOL were found between the groups (P > 0.05). Patients with CLP reported a better OHRQOL (P = 0.025) in the physical pain, physical disability, and psychological disability domains (P < 0.05). Patients with CLP presented with less myofascial pain (OR, 0.28; 95% CI, 0.11-0.71] and other articular conditions (OR 0.24; 95% CI 0.06-0.90]. More patients with CLP reported no chronic pain (P = 0.012). The QOL of patients with CLP with no depression or with no nonspecific physical symptoms including pain (NSPSIP) was better than that of patients without CLP. The OHRQOL of patients with CLP without TMDs or no psychological factors was better than that of patients without CLP. Patients with skeletal Class III malocclusion who require orthognathic surgery with CLP have better OHRQOL and present with fewer TMDs than those patients without CLP.

The Impact of COVID-19 Pandemic on Searching for Health-Related Information and Cyberchondria on the General Population in Italy.

Objectives: The Internet has become one of the most common sources people use to search for health-related information, a behavior rapidly increased during the novel Coronavirus disease 2019 (COVID-19). The present study aimed to investigate behavioral patterns in the online health-related searches and Cyberchondria (CYB) during the COVID-19 pandemic time, in order to explore socio-demographic and psychopathological factors related to CYB.Methods: During the third wave of the COVID-19 pandemic in Italy, a cross-sectional online survey collected the main socio-demographic variables and habits related to Internet use of 572 participants. CYB was measured by the Cyberchondria Severity Scale-Short Version and different psychopathological factors were measured by specific questionnaires: the Coronavirus Anxiety Scale, the Hospital Anxiety and Depression Scale, the Short Health Anxiety Inventory, the Meta-Cognitions about Health Questionnaire, the Internet Addiction Test, the Maudsley Obsessional-Compulsive Questionnaire-Short Version, the Rosenberg's Self-Esteem Scale, and the WHO Quality of Life-BREF. Descriptives, non-parametric ANOVAs, and Spearman correlations were performed.Results: In the present sample, the Internet was the main source participants used to search for health-related information and nearly one-third increased this habit during the pandemic. Higher expression of CYB emerged in females, in younger participants, in students, and in those suffering from a physical/psychiatric illness. CYB showed a positive correlation with different phenomenology of anxiety (i.e., anxiety about COVID-19, health anxiety, general anxiety, metacognitive believes about anxiety) and with depression, obsessive-compulsive symptoms, and problematic usage of the Internet. Conversely, quality of life and self-esteem showed a negative correlation with CYB.Conclusion: During the COVID-19 pandemic, the use of the Internet for health-related information and CYB contribute to the psychological stress affecting individuals and society. Delineating subjects more vulnerable to CYB and associated psychopathological factors will help to elaborate operational indications for prevention and psychological support.

Acceptance of illness, quality of life and nutritional status of patients after lower limb amputation due to diabetes mellitus

Diabetes mellitus is one of the most common chronic diseases with a high number of sufferers worldwide. Diabetic neuropathy and diabetic angiopathy lead to serious infectious complications which are very difficult to combat and may finally lead to the amputation of a lower limb. The aim of the study was to evaluate the quality of life, the level of acceptance of the illness and the nutritional status of patients after lower limb amputation due to diabetes. Ninety-nine patients (23 men and 76 women) were enrolled into the study. They had all undergone lower limb amputation due to diabetic foot and were treated in the Department of General and Oncological Surgery. The following questionnaires were used: the WHO Quality of Life-BREF (WHOQOL-BREF), the Mini Nutritional Assessment (MNA), the Acceptance of Illness Scale (AIS) and the anonymous specific socio-demographic characteristics questionnaire. The diabetes-related amputees were revealed to have a higher QoL within the social domain (mean score 64.48), an intermediate QoL - within the environmental domain (mean score 63.04) and the mental domain (mean score 59.61), and a lower QoL - within physical (somatic) domain (mean score 54.69). There was no statistical correlation between genders or between all the domains of QoL (P > 0.05). The mean MNA score was 22.66, which means that patients were at risk of malnutrition. There were statistical differences between women and men as regards nutritional status (P=0.034). The mean AIS score was 27.65 (27.09 women and 29.48 men), which means that the respondents accept their disease. There was no statistical correlation between gender and the acceptance of the disease (P=0.288). There was not statistical correlation between age and QoL (P > 0.05). There were statistical differences between age and nutritional status (P < 0.05), and between age and acceptance of the illness (P=0.044). The better the quality of life was in all the domains, the better the level of acceptance of illness was. The less malnourished the patient was, the better their quality of life was in all the domains.

Assessing the Quality of Life of Oral Submucous Fibrosis Patients: A Cross-Sectional Study Using the WHOQOL-BREF Tool.

The aim of the present study was to evaluate the quality of life (QoL) of oral submucous fibrosis (OSMF) patients using the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire. This cross-sectional study was conducted at the Department of Oral and Maxillofacial Surgery, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro. We used the consecutive sampling technique to recruit patients who were clinically diagnosed with OSMF (n = 112). Data were collected using the WHOQOL-BREF questionnaire, which contains a total of 26 questions. The first two questions, related to overall QoL and overall health status, were evaluated separately. The remaining questions (3–26), which represented four domains—physical, psychological, social, and environmental health—were evaluated separately. Patients were asked questions in their native language (Urdu). The relationship between these four domains of life was evaluated with gender, age categories, functional staging, and habit duration using the independent t-test to determine statistical significance. Cronbach’s Alpha was used to assess the reliability of the WHOQOL-BREF domains. The overall QoL of the OSMF patients was considerably poor, and the majority of the patients were unsatisfied with their oral health status. The age variable significantly affected the scores of all domains except for social relationships, whereas habit duration and functional staging of OSMF did not significantly affect the scores of all domains. The domains of the WHOQOL-BREF questionnaire (translated into the Urdu language) showed good reliability, except for social relationships.

Gender and Age Factors in Subjective Wellbeing and Quality of Life Among College Students

Quality of life (QOL) and subjective well-being (SWB) among college students have been deemed as importantissues in studies. The present study aims to explore any influential elements of gender and age to their QOL andSWB, and to know if the QOL is influential to the SWB. Participants amounted to 651 respondents totally fromthree Indonesian universities (Diponegoro University, Padjajaran University, North Sumatra University) wereinvolved in a purposive sampling using two instruments, i.e., the Personal Wellbeing Index-Adult (PWI-A) tomeasure SWO and The World Health Organization Quality of Life-BREF (WHOQOL-BREF) to measure QOL.Ordinal Logistic Regression (OLR) test was used in the analysis. The results showed that age and gender had asignificant effect on SWB (respectively .11 &amp; .040, with p &lt; .05) but had no effect on QOL of students(respectively .510 &amp; .751, with p &lt; .05). In addition, QOL was shown to affect SWB (p &lt; .05). As a result,counselors and stakeholders on campus are encouraged to consider age and sex factors in their attempts ofincreasing college students’ SWB. However, further research is still suggestible to explore more complex factorsin college students’ QOL, which can include social, individual, and other demographic factors.

Improving the Quality of Life for the Elderly with Degenerative Diseases through to the Charitas Group Virtual Health Education Program during the Pandemic of the COVID-19

Background: In the era of the COVID-19 pandemic, various problems were experienced by the elderly, especially those with degenerative diseases, as the population most at risk of being exposed to COVID-19. The elderly are vulnerable to decreased physical, mental and social health; therefore, a new and effective strategy is needed to improve healthy living behavior in this population. This study aimed to analyze the effect of the Charitas Group virtual health education program on improving the quality of life of the elderly with degenerative diseases in the era of the COVID-19 pandemic.&#x0D; Methods: The One Group Pretest-Posttest Pre-Experimental study was with a sample of 33 patients selected by purposive sampling in May - July 2021. The data collection was taken using the World Health Organization Quality of Life – Bref (WHOQOL-Bref) form, translated and validated into Bahasa Indonesia. The data was then compared before and after the intervention and analyzed using the Paired Samples T-Test.&#x0D; Results: The T-Test showed a significant difference between the pre-test and post-test results (p-value 0.041 &lt; 0.05). At the same time, the other T-Test results showed a significant influence on the quality of life of the elderly in the specific domains, namely: Psychological (p-value 0.025), Social Relationship (p-value 0.033) and Environmental (p-value 0.034).&#x0D; Conclusions: The Charitas Group virtual health education program significantly influences the quality of life of elderly people with degenerative diseases in the COVID-19 pandemic era.

Improving the Quality of Life for the Elderly with Degenerative Diseases through to the Charitas Group Virtual Health Education Program during the Pandemic of the COVID-19

Background: In the era of the COVID-19 pandemic, various problems were experienced by the elderly, especially those with degenerative diseases, as the population most at risk of being exposed to COVID-19. The elderly are vulnerable to decreased physical, mental and social health; therefore, a new and effective strategy is needed to improve healthy living behavior in this population. This study aimed to analyze the effect of the Charitas Group virtual health education program on improving the quality of life of the elderly with degenerative diseases in the era of the COVID-19 pandemic.&#x0D; Methods: The One Group Pretest-Posttest Pre-Experimental study was with a sample of 33 patients selected by purposive sampling in May - July 2021. The data collection was taken using the World Health Organization Quality of Life – Bref (WHOQOL-Bref) form, translated and validated into Bahasa Indonesia. The data was then compared before and after the intervention and analyzed using the Paired Samples T-Test.&#x0D; Results: The T-Test showed a significant difference between the pre-test and post-test results (p-value 0.041 &lt; 0.05). At the same time, the other T-Test results showed a significant influence on the quality of life of the elderly in the specific domains, namely: Psychological (p-value 0.025), Social Relationship (p-value 0.033) and Environmental (p-value 0.034).&#x0D; Conclusions: The Charitas Group virtual health education program significantly influences the quality of life of elderly people with degenerative diseases in the COVID-19 pandemic era.

Lower sexual satisfaction in women with polycystic ovary syndrome and metabolic syndrome.

BackgroundPolycystic ovary syndrome (PCOS) is a multi-symptom disorder linked with a range of metabolic and hormonal disturbances. Psychological and sexual aspects of PCOS also need to be considered.Objective of the study This study aimed to assess sexual satisfaction (SS) in PCOS patients and eumenorrheic controls (CON). The relationships between SS, depressive symptoms, health-related quality of life (HRQoL), and hormonal and metabolic profiles were evaluated.Methods In this study, 190 patients with PCOS (mean age 26.34 ± 5.47 years) and 197 age-matched CON (mean age 27.12 ± 4.97 years) were enrolled. All subjects completed Polish version of the Sexual Satisfaction Questionnaire (SSQ), WHO Quality of Life-BREF (WHOQOL-BREF), and the Center for Epidemiologic Studies Depression Scale-Revised (CESD-R) questionnaire. Fasting blood samples were collected to assess hormonal, lipid, and glucose profiles. Anthropometric measures were collected. Metabolic syndrome (MS) was evaluated according to the IDF-AHA/NHLBI criteria.Results Patients with PCOS and MS had lower SS vs non-MS-PCOS. There were no significant differences in the level of SS, presence of depressive symptoms, or HRQoL between PCOS and CON (P > 0.05). Negative correlations were found between the SS level and BMI, waist circumference, and waist-to-height ratio in PCOS women. However, overweight or obese PCOS women did not differ in SS levels vs normal-weight PCOS patients. The social dimension of WHOQOL-BREF was the only significant predictor of SS in PCOS patients.Conclusions SS in PCOS women appears to be undisturbed. However, MS in PCOS patients could negatively influence SS. The level of SS should be assessed in PCOS women, especially if MS is present.

STUDY CORRELATION BETWEEN BURDEN AND QUALITY OF LIFE OF DEPENDENT ELDERLY CAREGIVERS IN KLITREN, YOGYAKARTA

Introduction: Elderly with disabilities need caregiver’s assistance in their activities of daily living. The caregiver can experience a burden during caring for dependent elderly. The burden can affect the caregiver’s quality of life. Purpose: To measure and test the correlation between dependent elderly’s caregiver burden and quality of life in Klitren Kampong, Gondokusuman District, Yogyakarta Municipality. Method: The subjects were primary informal caregivers aged ≥ 18 years with an excellent cognitive function caring for the elders with an ADL score &lt;12. Respondents were selected using the consecutive sampling technique. This is quantitative research with a cross-sectional study design. Zarit Burden Interview and Caregiver Reaction Assessment were used to assessing the caregiver’s burden. WHO Quality of Life-BREF was used to assess caregiver’s quality of life. Data were analyzed using spearman’s rank correlation. Results: There were 21 female study subjects. The caregivers ' burden tended to be low in each of the CRA and ZBI domains (mean=8.63±10.730–72.42±10.983). Caregivers’ quality of life tended to be low (mean=49.76±11.962–60.76±11.726). There was a strong and statistically significant correlation between the impact on finance (p=0.000, ρ=-0.678) and the impact on health (p=0.002, ρ=-0.602) on CRA with the environmental domain of WHOQoLBREF. There was a strong and statistically significant correlation between the impact of the schedule domain on CRA with the psychological domain of WHOQoL-BREF (p=0,000, ρ=0.683). Conclusion: There are significant correlations between caregivers’ burden and quality of life, especially in specific domains. Caregivers with a higher burden have a lower quality of life.

Pain index and health-related quality of life in a Nigerian patients cohort with sickle cell anaemia

The severity of sickle cell anaemia (SCA) often causes painful episodes of vaso-occlussive crises and affects quality of life. Poor health-related quality of life (HRQoL) associated with sickle cell disease has been established. The study aim was to determine the relationship between pain index and HRQoL in Nigerian patients with SCA. The study was a cross-sectional survey of SCA individuals. Data collection was done using socio-demographics and clinical characteristics questionnaire, Wong-Baker FACES pain rating scale, and WHOQoL-Bref. Descriptive, cross-tab and multinomial logistic regression analyses were used to analyze the data in SPSS® version 20 IBM, USA. A total of 226 SCA individuals (males = 111 (49.1%) and females = 115 (50.9%)) with mean age 28.9±8.5 years participated in this study. Greater than 80% of the SCA individuals with pain had poor HRQoL score. Overall, with the range of statistically significant Chi-square value 49.715-94.474 (Cramer’s V = 0.469-0.647), strong association was observed between pain index and all HRQoL domains. Logistic regression analysis also revealed pain rating (pain relative to no pain) significantly predicted increased odds of affecting physical health (OR = 5.030; 95% CI = 1.094-23.118; P value = 0.038) as well as social and relationship status (OR = 9.443; 95% CI = 3.228-27.618; P value < 0.001) among SCA individuals. In conclusion, individuals with SCA largely have poor HRQoL. However, pain affects domains of HRQoL, particularly the physical health and social and relationship status domains of health. Key words: Sickle cell anaemia (SCA), pain, health-related quality of life (HRQoL), World Health Organization Quality of Life-Bref (WHOQoL-Bref).

A Quasi-Experiment on the Effectiveness of Cardiac Rehabilitation in Quality of Life of Cardiac Patients with the Caregivers’ Involvement

Introduction: Coronary Heart Disease can result in impaired quality of life which can inhibit an early recovery with successful outcomes for cardiac patients. Objective: To investigate the effect of a structured cardiac education and early intervention cardiac rehabilitation program on quality of life in cardiac patients involving caregivers. Method: A quasi experimental study with a purposive sampling was carried out where 132 acute coronary syndrome patients hospitalized for treatment were recruited and allocated to the experiment and control group with and without caregivers. A structured educational intervention and cardiac rehabilitation was initiated for the experimental group with and without caregivers. The outcome was measured using the World Health Organization Quality Of Life-BREF (WHOQOL-BREF) instrument.Results: Data was measured with repeated measures ANOVA between baseline, discharge and follow-up between the intervention and control group with p&lt;0.05 There was a statistically significant difference in QOL in both the groups with and without caregivers in the following domains: psychological health (F=3.784, p=0.002); social relationship (F=4.267, p=0.000) and environment (F=3.578, p=0.004). There was not a statistically significant difference between both the groups in the physical health domain (F=1.316, p=0.266).Conclusion: The results indicated that a structured cardiac educational intervention and cardiac rehabilitation with the involvement of the caregivers have significant effects on the quality of life of cardiac patients. The findings provide useful evidence to improve health outcomes of acute coronary syndrome patients involving the caregivers.

The Big-Five Personality Traits and Quality of Life in Elderly Malaysian Patients with Diabetes Mellitus: A Cross-Sectional Study

While diabetes mellitus is highly prevalent in the elderly population with significant impact on quality of life (QOL), we yet to know much about how personality traits affect QOL in this patient population. A cross-sectional study was conducted at Universiti Kebangsaan Malaysia Medical Centre with the aim to determine the relationship between personality traits and QOL among the elderly (aged ≥60 years) with diabetes mellitus. Sociodemographic and clinical information were obtained. QOL was assessed using the WHO Quality of Life-BREF (WHOQOLBREF) questionnaire and personality traits were assessed using the Big Five Inventory (BFI) questionnaire. Depression and anxiety were measured with Beck Depression Inventory-II (BDI-II) and Generalized Anxiety Disorder 7-item (GAD-7) scale, respectively, and controlled for in all analyses. There were in total 170 study participants (median age=69.0 years; IQR: 65.0-73.0; 51.2% male). In stepwise linear regression models, higher conscientiousness scores (β=0.156; P=0.044) and lower neuroticism scores (β=-0.176; P=0.028) were associated with greater QOL in the physical health domain. Higher extraversion scores (β=0.209; P=0.001) and higher conscientiousness scores (β=0.248; P&lt;0.001) were associated with greater QOL in the psychological health domain. Higher agreeableness scores (β=0.286; P&lt;0.001) were associated with greater QOL in the social relationship domain. Finally, higher agreeableness scores (β=0.327; P&lt;0.001) and lower neuroticism scores (β=-0.223; P=0.001) were associated with greater QOL in the environment domain. Personality traits were closely associated with all domains of QOL among elderly patients with diabetes mellitus. Premorbid personality may have important role in moderating the impact of diabetes mellitus on the lives of elderly patients.

Study Protocol: Transition_psy a Multicenter Prospective Longitudinal Cohort Study Assessing Risk and Protective Factors to Develop Psychopathology in Transitional Age Youth in Belgium.

Introduction: Emerging adults are a particularly at-risk population in mental health. The primary aim of the Transition_psy study is to evaluate changes in mental health care need and quality of life during transition from Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS). The relationship between these changes and genetic or environmental vulnerabilities and clinical dimensions representing risk and protective factors to the development of psychopathology will be analyzed. We also aim to explore how each factor plays, specifically, a role in developing internalizing and externalizing symptoms, in order to predict the most common paths of psychopathology in transitional age youth (TAY).Methods and Analysis: Transition_psy is a multicenter prospective longitudinal cohort study. The transversal and trans-diagnostic approach consists of a dimensional evaluation: 300 youth at the age of 17 will be included in a cohort of in-patients, out-patients and control group. Participants will be assessed at baseline (T0) and 24 months later (T1). The primary objective to determine changes in self-rated Health Of The Nation Outcome Scales For Children And Adolescents (HONOSCA-SR) and WHO Quality of Life-BREF (WHOQOL-BREF) scores between T0 and T1. Pearson correlation and mediation analysis will be performed. A secondary objective analysis using mediation and moderation models with several dimensional aspects, including self-reported and cognitive measures, will be conducted to disentangle the potential relationships between the two scores.Discussion: Transition from CAMHS to AMHS occurs at a crucial age in terms of the continuum between adolescent and adulthood psychopathology. This collaborative and cohesive protocol between CAMHS and AMHS represents the first national cohort study about Transition Psychiatry in French-speaking Belgium.Ethics and Dissemination: The study protocol was approved by the Institutional Review Boards (IRB) of the three participating sites. Results will be published in peer-reviewed journals and disseminated at national and international conferences. This trial was registered in ClinicalTrials.gov (Identifier: NCT04333797) on 3 April 2020.

Quality of Life of Patients with Wilson's Disease and Their Families

Wilson's disease (WD) is a chronic disease caused by altered copper metabolism requiring lifelong therapy. Its long-term and debilitating nature has the potential to affect the quality of life (Qol) of patients as well as their families. Our study aims to assess this impact of the disease on patients and their families. We conducted a prospective, observational study over 2 years on 73 patients and 73 age-matched controls with 33 children and 40 adults in each group. The Qol of cases and controls was assessed using the PedsQLGeneric Core Scales and World Health Organisation Quality of Life BREF (WHOQOL-BREF) for children and adults, respectively. Families of child and adult patients were interviewed using PedsQLFamily Impact Module and Family Attitude Scale (FAS), respectively. The data were statistically analyzed. Mean age of the cases was 22.04±11.8 years. Qol scores for both adults and children were worse in cases with neuropsychiatric disease than in those with hepatic disease. For children, the mean scores of overall psychological functioning were lower in cases compared with controls (P=0.0001). Qol of parents of the patients was significantly lower than those of parents of the controls as was the family functioning (P=0.0001 and P=0.016). Family Attitude Scale scores for adults did not differ significantly between cases and controls. The Qol of patients with neuro-WD is worse than that of hepatic disease. The disease impacts the psychological functioning of the children and the Qol of their families, which improves with the duration of the disease. WD is a long-term, debilitating disease. Patients have to take lifelong treatment with frequent medical visits and often multiple hospitalizations. WD affects the Qol of not only the patients but also their families. Qol of patients with neuro-WD is worse than that of patients with hepatic disease.

Prevalence and correlates of depression and quality of life among primary caregivers of patients with schizophrenia attending a Nigerian Tertiary Hospital

AimsTo determine the prevalence and correlates of depression and quality of life and their relationship among primary caregivers of patients with schizophrenia in a psychiatry specialist hospital.MethodA total of 138 caregivers of patients diagnosed with schizophrenia attending the outpatient clinic of the Neuropsychiatric Hospital Aro, Abeokuta were recruited. Sociodemographic questionnaire, Mini International Neuropsychiatric Interview (MINI-PLUS) (depressive module) and World Health Organization Quality of Life-Bref (WHOQOL-Bref) were administered on the caregivers while Brief Psychiatric Rating Scale (BPRS) was used to measure symptoms severity in the patients.ResultThe mean (±SD) age of respondents was 48.3 years (±14.7), 53.6% were females and 33.3% were without partners. The prevalence of depression among the caregivers who participated in the study was 13.8%. Female gender (χ2 = 5.68, df = 1, p = 0.02), hailing from a minority tribe (χ2 = 9.78 df = 1, p &lt; 0.01), and Previous treatment for mental illness (χ2 = 8.24 df = 1, p &lt; 0.01) were associated with depression. Female gender (ß = 1.35, OR = 3.86, p = 0.03), minority tribe (ß = 1.95, OR = 7.03, p &lt; 0.01), and previous treatment for mental illness (ß = 3.19, OR = 24.21, p = 0.01) were independently predictive of depression in the caregivers.Independent predictors of lower quality of life (QOL) were: Parents/siblings relationship for social relationship domain (ß = −7.076, p = 0.037) and spending more than 35 hours per week for Environmental domain (ß = −5.622, p = 0.028).Finally, a significant correlation was also found between Depression and Psychological Domain of QOL (t = 3.048, p &lt; 0.01) and Social Domain of QOL (t = 2.154, p = 0.03).ConclusionThis study shows that primary caregivers of patients with schizophrenia have high prevalence of depression and poor quality of life. There is need to pay attention to the psychological wellbeing and quality of life of caregivers who come in contact with psychiatric services, and not just the patients they accompany.

An epidemiological study on quality of life among elderly in an urban area of Thirumazhisai, Tamilnadu

Introduction:One of the most important indicators of health and well being of the elderly is the quality of life they live in. Owing to the rise in elderly population due to the demographic transition, there is growing need to address the health concerns of this population.Aims:The study was undertaken to find out the Quality of Life among the elderly and the associated factors.Methodology:This is a descriptive cross sectional study done in urban area of Thiruvallur district Tamil Nadu. To arrive at the required sample of 199, elderly people above 60 years were selected by probability proportionate to size sampling. Semi-structured pre-tested questionnaire was used for data collection regarding sociodemographic details and related factors. Katz scale was used to assess activities of daily living and Quality of life (QOL) was assessed using WHO quality of life BREF (WHOQOL BREF) questionnaire.Results:Moderate score in QOL was obtained in all the 4 domains with highest in Psychological and environmental domains. Nearly 99% of had full activity in Katz scale. All the three QOL domains were found to have statistical significant association with age and education. Gender and marital status were found to be associated with psychological domain, and employment/pensioner status with physical domain.Conclusion:Measures like Health education have to be targeted for the elderly in ways to improve their physical and psychological wellbeing which can imporove the quality of life they live in. Primary care and family physicians have to be made aware and empowered to identify the various domains of QOL in elderly and to identify in which domain the person needs to take care the most.

Psychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case\u2013control study

Individuals with dentofacial deformities often display a low quality of life (QoL) through biological mechanisms that remain unraveled. In this case–control study, the salivary levels of cytokines, glutamate, and kynurenine metabolites were assessed in patients undergoing orthognathic surgery (OS), while correlating these parameters with QoL and psychological symptoms. Thirty-six patients were enrolled in control (under orthodontic treatment) and test (undergoing OS) groups, matched by age and sex. The QoL was assessed through the World Health Organization Quality of Life BREF (WHOQOL-BREF) and the Orthognathic Quality of Life Questionnaire (OQLQ). The psychological symptoms were evaluated by the Satisfaction with Life Scale, the Rosenberg Self-Esteem Scale (RSES), and the Depression, Anxiety, and Stress Scale-21 (DASS-21). The salivary levels of IL-1β, IL-6, IL-10, glutamate, and kynurenine metabolites were evaluated. The OQLQ demonstrated increased QoL scores in the test group, regarding social aspects, facial esthetics, and function domains, without significant differences in respect to the other surveys. These patients displayed higher IL-1β and glutamate levels; conversely, the kynurenine metabolites were unaltered. The glutamate levels positively correlated with the OQLQ function scores. The data brings novel evidence about the psychobiological features of patients with dentofacial deformities, showing salivary variations of inflammatory biomarkers in these individuals.