Background: Education has become one of the clearest indicators of life outcomes such as employment,income and social status, and is a strong predictor of attitudes and well-being. The top most among professionaloriented courses are Medicine and Engineering. Medical Education is perceived as being stressful, and ahigh level of stress is caused by strenuous medical programs, which may have physical and psychologicaleffects on the well-being of medical students. Engineering students take half-yearly examinations, ascompared to the annual examinations taken by medical students which leads to a higher prevalence of stressamong engineering students.The aim is to compare and study the Impact of Education on OccupationalPerformance and Quality of Life in Medical students and Other Science Professional Course (Engineering).Method:135 individuals (70= medical field & 65= engineering field) were screened from different collegesof Nagpur city. A convenient sample of 100 students (male & female) from different colleges were dividedinto 2 groups of 50 each - Group A: Medical stream and Group B: Engineering stream. The subjects wereasked to fill up the OPHI-II and WHOQOL-BREF questionnaire.Results: On the OPHI-II scale, the engineering students have better occupational identity and occupationalsettings as compared to the medical students whereas the occupational competence showed no significantdifference in both the fields. On the WHO Quality of life-BREF scale, the physical health and psychologicaldomains shows no significant difference in both the fields; whereas the social relationship and environmentdomains show significant difference in both the fields.Conclusion: There is an impact of education on the Occupational Performance and on Quality of Life instudents of both the fields. On the OPHI-II scale, engineering students have better occupational identity andoccupational settings in comparison to the medical students. On the WHOQOL-BREF scale, engineeringstudents have better quality of life in social relationships and environmental domain in comparison to themedical students.