We interpret heterotic M-theory in terms of h-cobordism, that is the eleven-manifold is a product of the ten-manifold times an interval is translated into a statement that the former is a cobordism of the latter which is a homotopy equivalence. In the non-simply connected case, which is important for model building, the interpretation is then in terms of s-cobordism, so that the cobordism is a simple-homotopy equivalence. This gives constraints on the possible cobordisms depending on the fundamental groups and hence provides a characterization of possible compactification manifolds using the Whitehead group – a quotient of algebraic K-theory of the integral group ring of the fundamental group – and a distinguished element, the Whitehead torsion. We also consider the effect on the dynamics via diffeomorphisms and general dimensional reduction, and comment on the effect on F-theory compactifications.