White-light Imaging Group Research Articles

Detectability of colorectal neoplastic lesions using a novel endoscopic system with blue laser imaging: a multicenter randomized controlled trial

Most studies have not reported an improvement in the detection of adenomas with the use of image-enhanced colonoscopy methods, possibly because of the darkness of the images. To overcome this limitation, a new-generation endoscopic system has been developed. This system has 2 blue-laser imaging (BLI) observation modes. The BLI observation was set to BLI-bright mode to detect lesions. We aimed to evaluate the efficacy of BLI in detecting lesions. This study was designed as a randomized controlled trial with participants from 8 institutions. We enrolled patients aged≥40 years. The participants were randomly assigned to 2 groups: observation by using white-light imaging (WLI) with a conventional xenon light source (WLI group) or observation by using BLI-bright mode with a laser light source (BLI group). All of the detected lesions were resected or had a biopsy taken for histopathologic analysis. The primary outcome was the mean number of adenomas per patient (MAP) that were detected per procedure. The WLI and BLI groups consisted of 474 and 489 patients, respectively. The MAP was significantly higher in the BLI group than in the WLI group (mean ± standard deviation [SD] WLI 1.01 ± 1.36, BLI 1.27 ± 1.73; P= .008). Adenoma detection rate in the BLI group was not significantly higher than in the WLI group. Observation times differed significantly, with BLI (9.48 minutes) being longer than WLI (8.42; P< .001). The mean (± SD) number of polyps per patient was significantly higher in the BLI group compared with the WLIgroup (WLI 1.43 ± 1.64, BLI 1.84 ± 2.09; P= .001). A newly developed system that uses BLI improves the detection of adenomatous lesions compared with WLI. (Clinical trial registration number: UMIN 000014555.).

Next-generation narrow band imaging system for colonic polyp detection: a prospective multicenter randomized trial.

Previous studies have yielded conflicting results on the colonic polyp detection rate with narrow-band imaging (NBI) compared with white-light imaging (WLI). We compared the mean number of colonic polyps detected per patient for NBI versus WLI using a next-generation NBI system (EVIS LUCERA ELITE; Olympus Medical Systems) used with standard-definition (SD) colonoscopy and wide-angle (WA) colonoscopy. this study is a 2 × 2 factorial, prospective, multicenter randomized controlled trial. this study was conducted at five academic centers in Japan. patients were allocated to one of four groups: (1) WLI with SD colonoscopy (H260AZI), (2) NBI with SD colonoscopy (H260AZI), (3) WLI with WA colonoscopy (CF-HQ290), and (4) NBI with WA colonoscopy (CF-HQ290). the mean numbers of polyps detected per patient were compared between the four groups: WLI with/without WA colonoscopy and NBI with/without WA colonoscopy. Of the 454 patients recruited, 431 patients were enrolled. The total numbers of polyps detected by WLI with SD, NBI with SD, WLI with WA, and NBI with WA were 164, 176, 188, and 241, respectively. The mean number of polyps detected per patient was significantly higher in the NBI group than in the WLI group (2.01 vs 1.56; P = 0.032). The rate was not higher in the WA group than in the SD group (1.97 vs 1.61; P = 0.089). Although WA colonoscopy did not improve the polyp detection, next-generation NBI colonoscopy represents a significant improvement in the detection of colonic polyps.

MP22-16 RECURRENCE RATE OF TRANSURETHRAL RESECTION OF BLADDER TUMOR USING NARROW BAND IMAGING: A RANDOMIZED CONTROL TRIAL, PILOT STUDY

You have accessJournal of UrologyBladder Cancer: Detection & Screening1 Apr 2014MP22-16 RECURRENCE RATE OF TRANSURETHRAL RESECTION OF BLADDER TUMOR USING NARROW BAND IMAGING: A RANDOMIZED CONTROL TRIAL, PILOT STUDY Joo Yong Lee, Jae Hyeok Choi, In Kyoung Kim, Hae Do Jung, Ho Won Kang, Ki Soo Lee, Young Eun Yoon, Ji Yong Ha, Kang Su Cho, Joong Shik Lee, In Rae Cho, and Young Deuk Choi Joo Yong LeeJoo Yong Lee More articles by this author , Jae Hyeok ChoiJae Hyeok Choi More articles by this author , In Kyoung KimIn Kyoung Kim More articles by this author , Hae Do JungHae Do Jung More articles by this author , Ho Won KangHo Won Kang More articles by this author , Ki Soo LeeKi Soo Lee More articles by this author , Young Eun YoonYoung Eun Yoon More articles by this author , Ji Yong HaJi Yong Ha More articles by this author , Kang Su ChoKang Su Cho More articles by this author , Joong Shik LeeJoong Shik Lee More articles by this author , In Rae ChoIn Rae Cho More articles by this author , and Young Deuk ChoiYoung Deuk Choi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.864AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The standard non-muscle invasive bladder cancer (NMIBC) endoscopic diagnosis suffers from the frequently unsatisfactory white light imaging (WLI) accuracy leading to residual lesions being left behind. Narrow band imaging (NBI) is an optical image-enhancement technique in which modified optical filters are used in the light source of a video endoscope system. It can enhance the contrast between mucosal and microvascular structures, and distinguish superficial tumors and the normal mucosa. Thus, we evaluated the initial oncological outcomes of transuretheral resection (TUR) for NMIBC. METHODS Consecutive patients with overt or suspected NMIBC were included in a prospective study. Excluding patients with muscle-invasive bladder cancer, negative pathologic examination, or without follow-up, the study population was composed of 68 subjects randomized from Aug, 2010 to Feb, 2013 to NBI with TUR (33 cases) or WLI with TUR (35 cases). Patients’ age, tumor stage, and characteristics including mass size, multiplicity, carcinoma in situ (CIS) and grades were evaluated using Kaplan-Meier analyses. RESULTS Mean patient age was 63.13±12.42 years. Median follow-up (interquartile range; IQR) was 15.57 (9.82-32.10) months. There were no statistical differences in patients’ age (63.82±12.31 years vs. 63.03±12.43 years; p=0.793), and median follow-up periods (16.26 (11.60-20.76) months vs. 15.05 (9.48-32.71) months). In free recurrence analyses using Kaplan-Meier curve, recurrence-free rates were 77.2% (95% CI 61.1-97.7) in NBI group and 73.0% (95% CI 57.2-93.3) in WLI group at 24-months (p=0.416). In subanalyses, high grade (p=0.18), multiple mass (p=0.416), ≥65 years (p=0.696) and <65 years (p=0.525) demonstrated no statistical differences. In patients with CIS, there were no recurrence in NBI group, however, recurrence-free rates were 62.5% (95% CI 36.5-100) at 12 months and 25.0% (95% CI 7.5-83.0) at 24 months in WLI group (p=0.049). CONCLUSIONS TUR performed in the NBI modality reduces the recurrence risk of NMIBC in patients with CIS. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e240-e241 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Joo Yong Lee More articles by this author Jae Hyeok Choi More articles by this author In Kyoung Kim More articles by this author Hae Do Jung More articles by this author Ho Won Kang More articles by this author Ki Soo Lee More articles by this author Young Eun Yoon More articles by this author Ji Yong Ha More articles by this author Kang Su Cho More articles by this author Joong Shik Lee More articles by this author In Rae Cho More articles by this author Young Deuk Choi More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...