Landscape simulation and prediction are crucial for understanding the dynamic evolution and future trends of wetlands. However, only a few existing studies have focused on the applicability and limitations of commonly used land-use/cover change (LUCC) simulation models in lake wetland landscapes. Taking Shengjin Lake Reserve in China as the study area, we firstly analyzed landscape variations during 2010–2020 using multisource remote sensing images. Then, the patch-generating land-use simulation (PLUS) model was employed to simulate wetland landscapes in 2020, the accuracy and limitation of which in simulating lacustrine wetlands were also explored. Lastly, the changing trends of wetland landscapes in 2030 under different development scenarios were predicted. The results show that the landscape of Shengjin Lake Reserve has changed significantly during 2010–2020, with increases in mudflats, reservoirs/ponds, woodlands, and built-up land, and there has been decreases in lakes, grass beaches, and croplands. The PLUS model demonstrated an ideal simulation accuracy for Shengjin Lake Reserve, with the overall accuracy exceeding 80%, kappa coefficient greater than 0.75, and figure of merit (FOM) coefficient of 0.35, indicating that the model can capture the dynamic changes in wetland landscapes accurately. The simulation accuracy can be effectively improved with the adjacent initial year, shorter time interval, and the primary driver factors. Under the natural development scenario, the number of patches in the Shengjin Lake Reserve increased sharply, and landscape fragmentation intensified. Under the urban development scenario, the expansion of built-up land increased, and the average patch area increased. In the ecological protection scenario, the Shannon diversity index and Shannon evenness index of the landscape improved significantly, and the natural wetlands such as grass beaches and lakes can be protected effectively. Our study confirms the applicability of the PLUS model in simulating and predicting lacustrine wetlands landscapes, and the conclusions provide a scientific basis for formulating reasonable development strategies to realize wetland resource conservation and management.