Lightweight aircraft design emphasizes materials like composites, alloys, and advanced polymers to reduce weight while ensuring structural integrity. Streamlined aerodynamics, efficient propulsion systems, and optimized component layout further enhance performance. The purpose of this research is to develop an innovative aircraft design model for drones, integrating algorithm optimization techniques and lightweight materials to enhance the performance and efficiency of drones with the utilization of open-source software. We apply this structure to the construction of drones with fixed-wing (FW) and vertical take-off and landing (VTOL) configurations. The aircraft’s body is constructed using lightweight materials such as glass fiber fabric (Gff) and extruded polystyrene foam (XPS), employing a vacuum-assisted wet layup technique for fabrication. Multi-objective Co-evolving Ant Colony Optimization (MC-ACO) was used to improve the construction of drones with VTOL and FW capabilities. This strategy enabled it to be easier to achieve the trade-offs required for a generalist drone design, such as range, payload capabilities, and swarm operations, which were then evaluated against commercially available software to evaluate the effectiveness. Incorporating biomechanics into the design method permits higher consideration of user interaction with drones. The findings indicate that low-fidelity architecture is a suitable starting point for prototyping under limited time frames. The paper concludes with a discussion of the technical constraints of employing free software, as well as some practical concerns for flight testing drones with hybrid configurations.