Since the emergence of positive psychology, researchers are trying to establish relationships among positive psychological variables, individual characteristics and environmental factors, in order to find approaches to enhance well-being and psychological health.
 In this regard, researchers have been adopting Eastern or Western perspective. Researches with Western perspective have always been in the forefront, while Eastern perspectives, although being age-old systems, have emerged in the spotlight in recent decades. These two perspectives well-define cultural differences while also accounting for individual differences, therefore, considered important to study.
 Despite large number of studies on positive psychological variables, there is a need for establishing the role of cognitive aspects in positive psychological variables, furthermore so, in the light of Eastern perspective.
 Thus, the present study aimed to explore the mediational role of Triguna dominance in relationship of Rationality with Coping Humor. The study sample consisted of 100 mid-adults (40-65 years).
 Significant results of correlation and regression motivated to perform mediational analysis. The relationship of Rationality with Coping Humor was found to be 0.12 and 0.22 points higher as mediated by Rajas and Tamas guna respectively. Satva guna had no mediational role in their relationship.
 Coping humor is a relatively new variable in positive psychology with limited research and theoretical bases. The results of the study can guide researchers in the exploration of the variable and development of the theories and models based on integrated research findings, furthermore so, with an Eastern perspective of Triguna. The study can be implied to various psychological fields, like counselling, rehabilitation psychology, health psychology, and others, to develop interventions and techniques to increase Rationality, Coping humor, and Satva guna while decreasing Rajas and Tamas guna to boost mental health and well-being.