Abstract Introduction: Tuberculosis being a public health challenge has mental illness as a significant, hidden challenge. Tuberculosis-related perceived stigma and social support remain poorly understood in the developing world and the data on the assessment of perceived stigma and social support remain scarce. The present study was conducted to estimate the prevalence of depression in tuberculosis and its association with social support and perceived stigma. Materials and Methods: A cross-sectional analytical study was conducted at the Directly Observed Treatment Short course (DOTS) center in the government medical college of Western Maharashtra. Pretested and prevalidated questionnaires were used for data collection with face-to-face interviews carried out among study participants. Results: Overall, the prevalence of depression including mild mood disturbances was 26/160 (16.25%). Among various socio-demographic correlates, we found a significant association (P = 0.001) of marital status with depression in tuberculosis. it was found that there was a significant association between perceived stigma with depression (P = 0.001). The odds of depression among participants with perceived stigma was 15.24 times more (OR = 15.24) in comparison to the odds of depression in participants with no perceived stigma. Similarly, it was found that there was a significant association between poor social support with depression (P = 0.02). The odds of depression in participants with good social support were 72% lesser (OR = 0.28) than the odds of depression among participants with poor social support. Conclusion: In conclusion, this study highlights that depression is highly prevalent among patients with tuberculosis. Depression among tuberculosis patients was significantly associated with poor social support and perceived stigma. Thus, to improve tuberculosis treatment adherence, a patient-centric approach should be considered at the programmatic level with social support and awareness generation and other measures to mitigate stigma as its key components.
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