Literacy rates in Guatemala range from 40% to 90% but widespread poverty and malnutrition hinder school attendance and educational attainment. The Western Highlands region of Guatemala has a large indigenous population and a bilingual Spanish and K’iche’ curriculum. This study explores how child, family, and community factors influence positive school environment, using a sample of 1590 sixth grade students. For male students, increased parental involvement had a positive and direct influence on healthy school environment. For female students, increased parental involvement had a positive and direct influence on healthy school environment. Teacher–student relationships may be a critical point of intervention.