The Silante Formation is a thick series of continental deposits, exposed along a trench-parallel distance of approximately 300 km within the Western Cordillera of Ecuador. The origin, tectonic setting, age and stratigraphic relationships are poorly known, although these are key to understand the Cenozoic evolution of the Ecuadorian Andes. We present new sedimentological, stratigraphic, petrographic, radiometric and provenance data from the Silante Formation and underlying rocks. The detailed stratigraphic analysis shows that the Silante Formation unconformably overlies Paleocene submarine fan deposits of the Pilalo Formation, which was coeval with submarine tholeiitic volcanism. The lithofacies of the Silante Formation suggest that the sediments were deposited in a debris flow dominated alluvial fan. Provenance analysis including heavy mineral assemblages and detrital zircon U-Pb ages indicate that sediments of the Silante Formation were derived from the erosion of a continental, calc-alkaline volcanic arc, pointing to the Oligocene to Miocene San Juan de Lachas volcanic arc. Thermochronological data and regional correlations suggest that deposition of the Silante Formation was coeval with regional rock and surface uplift of the Andean margin that deposited alluvial fans in intermontane and back-arc domains.