The theory of quasi-Lie systems, i.e. systems of first-order ordinary differential equations that can be related via a generalized flow to Lie systems, is extended to systems of partial differential equations (PDEs) and its applications to obtain [Formula: see text]-dependent superposition rules, and integrability conditions are analyzed. We develop a procedure of constructing quasi-Lie systems through a generalization to PDEs of the so-called theory of quasi-Lie schemes. Our techniques are illustrated with the analysis of Wess–Zumino–Novikov–Witten models, generalized Abel differential equations, Bäcklund transformations, as well as other differential equations of physical and mathematical relevance.