Cross-laminated timber (CLT) has recently attracted significant interest in building timber or hybrid structures owing to the rapidly growing demand for low-carbon construction materials with excellent mechanical properties. To investigate the seismic performance of CLT structures adopting novel dissipative angle brackets and hold-downs with soft-steel and rubber (i.e., SRD-ABs and SRD-HDs), a series of shaking table tests were performed on two full-scale specimens, i.e., a benchmark specimen (Specimen Ⅰ) and a specimen with a multi-doorway at the ground (Specimen Ⅱ). Several representative ground motions, including the Turkey wave, El Centro wave, Wenchuan wave, and Shanghai artificial wave, were selected as excitations, whose peak acceleration increased gradually from 0.035 g to 0.80 g. The damage patterns of the structures were revealed, and the dynamic characteristics and responses were obtained and analyzed. The results show that the fundamental frequencies of Specimen Ⅰ and Specimen Ⅱ were 4.125 Hz and 3.625 Hz, respectively. The mode shapes of each specimen remained similar before tests with peak ground acceleration (PGA) of 0.51 g, with only a slight decrease of approximately 5 % in the fundamental frequency, indicating that the specimens only suffered minor damage because of the great energy-dissipating capacity of the SRD-ABs and SRD-HDs. After experiencing tests with PGA of 0.80 g, the specimen exhibited a maximum inter-story drift of 1/60 with a structural damping ratio of 13 %, and the damage was mainly exhibited at the SRD-ABs and SRD-HDs, which realized the performance objective of replaceability of dissipative connections and repairability of structures under the 9-degree rare earthquakes. Furthermore, non-linear numerical models were developed to duplicate the dynamic characteristics and responses of the test specimen, and the analytical results from the models show satisfactory agreement with the test results. Overall, the outcomes of this paper can provide valuable references for future research and applications of CLT structures with the SRD-ABs and SRD-HDs.