Individual Well-being Research Articles

Improving joy at work and reducing burnout in health care workers in Victoria, Australia using the Institute for Healthcare Improvement joy in work framework: A mixed-methods study.

Burnout in health care workers (HCWs) has serious ramifications for individual well-being, patients, organizations, and health systems. Global evidence demonstrates the COVID-19 pandemic has amplified the risk of burnout. Scalable interventions to address burnout are critical to protect HCW well-being. Underpinned by the Conservation of Resources theory, this study examines the impacts of a statewide improvement initiative (the Initiative), using the Institute for Healthcare Improvement Joy in Work (JiW) Framework, to reduce burnout and increase joy at work across participating health care organizations in Victoria, Australia. An impact evaluation was undertaken utilizing a mixed-methods design. Quantitative outcomes included burnout and joy at work measured using an adapted Mini Z tool. In-depth interviews with implementation teams sought insights into the effectiveness of interventions. Overall, 20 teams from 17 organizations across diverse health care settings and geographical locations participated. At a statewide level, outcomes in burnout and joy at work were inconclusive due to limited data. However, five out of eight teams reporting sufficient data achieved measurable improvements in one or more outcomes. Qualitative data revealed the Initiative increased workplace resources and supports such as providing "permission" for HCWs to prioritize well-being at work, improved communications between management and HCWs, and increased HCWs' teamwork and camaraderie, resulting in safer and more positive workplaces. The JiW Framework, implemented across diverse settings, provided organizations with a structured process to develop multifaceted improvements that resulted in enhanced resources that appeared to improve HCW well-being. Compared to individual well-being support, this approach offers organization-level change and scalability potential.

Surfing a culturally-relevant physical activity: a new wave for health promotion

Abstract Background Surfing originated with Native Hawaiians prior to Western contact. It has since gained worldwide popularity, with an estimated 50 million surfers globally, and recently became an official Olympic sport. Associations have been reported between surfing and mental and physical health outcomes, greater community cohesion, and stronger intra-family relationships. Despite this evidence, surfing is deeply understudied in the context of health promotion. Purpose Surfing was analyzed from a mixed methods perspective to explore factors associated with lifetime participation and current engagement, including gender, race/ethnicity, chronic disease, social context, meaning, and average time of participation. Methods Hawai’i adult residents (n = 1066) completed an online or phone questionnaire. Modified Poisson regression models were fit for lifetime engagement and having a self-reported chronic disease, adjusting for primary race/ethnicity, age, gender, and education. Results Over their lifetime, 42% of respondents (50% men and 37% women) had participated in surfing. Engagement was highest during youth and young adulthood, and decreased with age, yet trends varied notably by race/ethnicity, gender, and generation. Lifetime surfing engagement was significantly related to lower likelihood of diabetes (aPR:0.72; 95%CI:0.56-0.92;p=0.009). Individuals who regularly participated in surfing typically did so with friends (78%) or family (61%); average surfing session duration was 209 minutes. Qualitative results revealed the relevance of surfing across levels of influence for health and wellbeing from physical fitness to community, culture, history and spirituality. Conclusions This work provides insights on the health promotion opportunities of surfing across the life-course and populations, including disease prevention and management. This study has implications for planning and policy locally and globally to achieve optimal community and planetary health. Key messages • Surfing is not only a sport for elite athletes, but also an activity that can support community and individual health and wellbeing in many populations over the lifespan. • Promotion of surfing and public ocean access can support multidimensional influences for wellbeing and should be a focus of cross sector collaborations for optimal community and planetary health.

A Multidisciplinary One Health Approach to Addressing Unsanitary Conditions: The Case of Cascais

Abstract Unsanitary conditions in domiciles often stem from complex social and health-related issues, involving the elderly and/or individuals with mental health problems. These situations typically lead to a decreased quality of life for those involved, directly and indirectly, and may pose a risk to public health depending on their magnitude. In Cascais municipality, identified cases of unsanitary conditions undergo a multidisciplinary analysis. It has been established a Local Technical Group for Domiciliary Unsanitary Situations, comprising various institutions such as local authorities, law enforcement agencies, civil protection, health and social security ministries, and the animal rescue center. This group operates under a One Health approach, encompassing human health, environmental health, and animal health. Interventions are determined by the working group, with the aim of promoting health and enhancing citizens’ quality of life. Cases of unsanitary conditions reported are subsequently discussed within the technical group, which has regular meetings, and may organize joint assessment visits and appropriate actions. This social and environmental initiative responds to the growing need to address unsanitary and cluttered living conditions, which significantly impact individuals’ physical, emotional, and social well-being. The objective is to restore housing conditions in homes by removing waste and unnecessary items, contributing to general individual well-being. While international studies suggest a correlation between unsanitary conditions and hoarding disorder, it’s crucial to differentiate between distinct and independent situations caused by various physical, psychological, and cognitive processes. The establishment of a Local Technical Group for Domiciliary Unsanitary Situations exemplifies a proactive approach to addressing complex health and social challenges, emphasizing collaboration, and holistic intervention strategies, always with a One Health approach. Key messages • Addressing unsanitary conditions is crucial for safeguarding public health, impacting physical, emotional, and social well-being. • The establishment of a Local Technical Group for Domiciliary Unsanitary Situations, under a One Health framework, reflects a collaborative approach to addressing complex health and social challenges.

Individual happiness and well-being as a strategy to increase productivity

This research aims to examine the role of happiness and well-being as key factors in enhancing individual productivity. With the growing body of research on mental health and well-being, a new understanding has emerged regarding the strong connection between emotional well-being and productive performance. Through a literature review, this study identifies and analyzes various empirical studies that explore the impact of happiness and well-being on productivity in different contexts, both in the workplace and in everyday life. The review process employed a systematic literature review method, with inclusion criteria encompassing studies published within the last four years and written in English or Indonesian. The findings indicate that happiness and well-being not only contribute to improved performance but also play a pivotal role in fostering an environment that supports sustainable productivity growth.

Love of life and flourishing in Turkish youth: mediating effects of optimism and hope

The concept of love of life, which refers to a positive attitude towards one's own life, care for it and attachment to it, has recently captured the attention of researchers in the field of positive psychology. Despite its growing importance, there is a lack of research investigating the underlying mechanisms through which love of life impacts the flourishing and well-being of individuals. For the first time, the present study examined the mediating roles of optimism and hope in the association between love of life and flourishing in Turkish youth. The study comprised 374 young adults, aged between 18 and 24 years (55.3% female; Mean age = 20.94; SD = 1.78 years), who participated in an online survey assessing their levels of love of life, optimism, hope, and flourishing. Results from the mediation analysis revealed that love of life significantly predicted optimism, hope, and flourishing. Furthermore, optimism and hope had significant predictive effects on flourishing. Importantly, optimism and hope played a partial mediating role in explaining the positive influence of the love of life on individuals' flourishing. The findings suggest a positive association between love of life and heightened levels of optimism and hope. These psychological attributes, in turn, emerge as crucial factors contributing to increased flourishing. These results hold significant implications for the development of interventions focused on understanding how to foster the love of life and flourish through the cultivation of psychological strengths.

Anxiety, depression, stress, and resilience among undergraduate nursing students at Al-Quds university: the impact of war started on October 7 in Palestine

BackgroundThe current outbreak of war in Palestine on the 7th of October 2023, heightened concerns about mental health and well-being of individuals, particularly undergraduate students in Palestine. Such traumatic experiences and political conflict did affect the social, economic, psychological, and academic status of university students in Palestine, in particular, nursing students. However, resilience is one of the moderators which may positively decrease the severity of those negative war-related symptoms.AimThe study aimed to examine the moderation effect of resilience on the relationship between sociodemographic and personal characteristics and depression, anxiety, and stress among undergraduate nursing students in Palestine.Design and methodsA quantitative, descriptive-correlational design utilized to investigate anxiety, depression, stress, and resilience among nursing students. A convenience sample of 325 nursing students recruited from Al-Quds University were asked to respond to a self-administered questionnaire.ResultsA total of 325 nursing students participated in this study. The analysis showed that the majority of the participants were experiencing extremely severe anxiety levels (43.7%, n = 142), while 25.5% (n = 83) were experiencing extremely severe depression and 14.5% (n = 47) were experiencing high-stress levels compared to 60% (n = 195) of the students were at their normal resilience level. There were statistically significant differences in the resilience based on sex (t323 = 2.994, p = .003). Knowing that males have higher resilience mean scores (M = 3.06, SD = 0.35) than females (M = 2.93, SD = 0.41) indicates higher resilience in males than females. After performing two steps of hierarchical regression, the results revealed that resilience negatively moderated the relationship between sociodemographics and depression, and anxiety.ConclusionThis study offers valuable insights into the mental health status of undergraduate nursing students in Palestine during the war. The results indicated that resilience is one of the pivotal moderators that may buffer anxiety and depression. The findings underscore the need for targeted interventions to address the diverse mental health needs of this population, considering the complex interplay of individual, demographic, and contextual factors. Future research should continue to explore these dynamics and evaluate the effectiveness of interventions promoting mental well-being during conflict.

Political polarization and health.

In addition to social determinants of health, such as economic resources, education, access to care and various environmental factors, there is growing evidence that political polarization poses a substantial risk to individual and collective well-being. Here we review the impact of political polarization on public health. We describe the different forms of polarization and how they are connected to health outcomes, highlighting the COVID-19 pandemic as a case study of the health risks of polarization. We then offer strategies for mitigating potential harms associated with polarization, with an emphasis on building social trust. Finally, we propose future research directions on this topic, underscore the need for more work in a global context and encourage greater collaboration between social scientists and medical scientists. We conclude that polarization is a serious-if largely overlooked-determinant of health, whose impacts must be more thoroughly understood and mitigated.

Effect of psychosocial safety climate on work-family conflict and psychological health among working couples.

The purpose of the study was to look into how work-family conflict (WFC), family-work conflict (FWC), and psychological health are affected by the psychosocial safety climate (PSC). First, the study suggested that for both husband and wife, PSC moderates the relationship between job demands and WFC. Second, the study predicted FWC mediates the relationship between WFC and depressive symptoms through the "crossover" process. The study design used a multi-source sample that involved 350 teachers and their working spouses (n = 700). The analysis of mediation and moderation among job demands, WFC, FWC, PSC, and depressive symptoms was conducted using SPSS and structural equation modeling AMOS software. For the teacher's sample, based on behavioral (β = 0.166, p < 0.05) and strain-based (β = 0.170, p < 0.05) aspects, the hierarchical regression analysis revealed that the PSC moderates the relationship between physical demand and WFC. The results also showed that the relationship between time-based WFC and emotional demand is moderated by PSC (β = 0.103, p < 0.05). Next, the analysis found that PSC moderates the association between cognitive demand and WFC of strain-based (β = 0.179, p < 0.05). For the spouse's sample, according to the analysis, PSC moderates the relationship between strain-based WFC and physical demand (β = 0.091, p < 0.05). The study also revealed that FWC serves as a mediator in the relationship between WFC and depressive symptoms in both husbands (β = 0.233, p < 0.01) and wives (β = 0.135, p < 0.001). Overall, this study contributes significant insights to the current literature by examining the impact of PSC on the psychological well-being of individuals and others through the crossover process.

A study on the impact of high-speed rail on the consumption structure of urban and rural residents in China.

Consumption is crucial to individual well-being and national economic development. This study investigates whether high-speed rail (HSR) influences consumption expenditure (CE) and consumption structure (CS) of urban and rural Chinese citizens. Using panel data from 2003 to 2019 and econometric models, this study finds that: (1) HSR significantly increases CE for both urban and rural residents, promotes CS upgrades in rural areas, but inhibits CS upgrades in urban areas. These results remain robust after extensive testing. (2) HSR's impact on urban consumption is relatively focused and singular, whereas its effect on rural consumption is dispersed and extensive. Additionally, the impact of HSR on consumption exhibited significant delays and regional characteristics. (3) Mediation analysis reveals that HSR significantly enhances urban and rural CE and facilitates rural CS upgrades through market, price, and income effects. However, it also triggers housing price increases, impeding urban CS upgrades. This study provides important references for the government to optimize transportation infrastructure investments, promote balanced economic development between urban and rural areas, and enhance residents' well-being.

Why a Distinct Islamic Economic Development Model is Necessary: Foundations and Framework of Islamic Moral Economy in Light of Islamic Ontology

This study examines the need for a distinct Islamic economic development model based on Islamic principles. The current global economic system faces significant income inequality and wealth distribution issues, prompting a search for alternative models. Many Muslim countries, having experienced both capitalism and socialism, struggle with high unemployment, poverty, and economic instability. The Islamic ethical economy offers a value-based approach that aims to reduce inequality and promote balanced growth through human-centered development. Key concepts such as Tawheed-ullah recognize Allah as the Creator and Owner, addressing resource imbalances and unjust allocation. Al'Adle Well Ehsan emphasizes social stability and participative development, while Tazkiyah focuses on purification, linking self-reliance to economic development. Furthermore, Ikhtiyar and Khalifa highlight the ethical responsibilities in the Islamic Moral Economy, and Maqasid Al Shari’ah outlines the objectives of Islamic law, emphasizing individual well-being. This study proposes a new Islamic Economic Development Model, drawing on Imam Al Ghazali’s ethical framework and integrating Amartya Sen’s Theory of Capabilities. The model considers both physical and psychological aspects of human development, aiming for success and happiness in this life and the afterlife. It aligns with Islamic goals, balancing material and intellectual development. By linking developmental goals in Islam with spiritual uplift, the study uses the Ghazalian ethical framework to achieve self and social development, ultimately attaining falah (success in the afterlife). This comprehensive approach ensures that worldly development aligns with spiritual objectives, promoting justice and equity in society.

The Effect of Cognitive Behavioural Therapy-Based Psychoeducation on Medication Adherence and Aggression in Individuals Diagnosed With Schizophrenia: An Experimental Study.

It is known that treatment compliance is low and aggression is higher in individuals diagnosed with schizophrenia compared to the normal population. Cognitive behavioural therapy (CBT) is known to reduce relapse and hospitalisation and increase well-being in individuals diagnosed with schizophrenia. However, there are almost no studies on increasing treatment compliance and decreasing aggression. This study was conducted to determine how CBT-based psychoeducation affects medication adherence and aggression in individuals diagnosed with schizophrenia. The study was conducted as a quasi-experimental model with the pre-test-post-test control group with 73 schizophrenic patients (33 experimental, 40 control) between June 2022 and July 2023. Data were collected using the Descriptive Characteristics Form, Morisky Medication Adherence Scale (MMAS) and Buss-Perry Aggression Questionnaire (BPSQ). The schizophrenic patients in the experimental group were given eight sessions of CBT-based psychoeducation, while the schizophrenic patients in the control group were not given any training. The data were analysed using mean, standard deviation, chi-squared test, dependent samples t-test and independent samples t-test. It was determined that the aggression level of the experimental group before the training was 80.51 ± 19.38, and after the CBT-based psychoeducation, it was 73.12 ± 15.28. It was determined that the aggression level of the control group before the training was 84.22 ± 12.13, and after the post-test, it was 85.60 ± 11.72. It was determined that the medication adherence level of the experimental group before the training was 2.75 ± 1.25, and after the CBT-based psychoeducation, it was 3.57 ± 0.67. It was determined that the medication adherence level of the control group before the training was 2.05 ± 1.33, and after the post-test, it was 2.17 ± 1.36. The psychoeducation based on CBT caused a statistically significant difference (p = 0.001) in medication adherence and aggression levels in the experimental group. It was determined that CBT applied to individuals diagnosed with schizophrenia was effective on increasing their medication adherence and reducing their aggression. It is recommended for psychiatric nurses to include CBT-based psychoeducation in their nursing practices in order to increase medication adherence and reduce aggression in individuals with schizophrenia. The findings emphasise that CBT-based psychoeducation increases treatment adherence and significantly decreases the level of aggression in individuals diagnosed with schizophrenia. Psychiatric nurses should include CBT-based psychoeducation in their treatments.

Considerations of Intersectionality in Psychological research

At the forefront of the increasingly popular intersectionality agenda in psychology is the wellbeing of individuals. The British Psychological Society states that a key principle of psychological research is to “consider societal benefits” and “contribute to the common good” (BPS, 2021). There is an abundance of evidence on the harmful outcomes of negative intergroup relations and systemic oppression on marginalised individuals. For example, marginalised groups often experience educational and economic disadvantages (Porter, 2011) alongside both physical and mental health disparities (English et al., 2022; Mitchell et al., 2021; Stevens-Watkins et al., 2014). Consequently, psychology as a discipline should prioritise advocating for a more equitable society.

Probiotics and Other Supplements for Autism Spectrum Disorder (ASD): A Comprehensive Review

Introduction: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by social interaction challenges, communication difficulties, and repetitive behaviors. While ASD lacks a cure, there is a growing interest in supplements, notably probiotics, for potential benefits. Probiotics are live microorganisms with health potential due to their role in the gut microbiome. Gut-brain axis is a bi-directional communication system that connects the gastrointestinal (GI) tract and the brain. Objective: This comprehensive review systematically searched scientific databases up to September 2023 to examine the use of supplements, particularly probiotics, in individuals with ASD. The review focused on addressing gut-related issues and improving behavior, speech, and overall well-being. Methods: A systematic search across databases such as PubMed, PsycINFO, and Cochrane library was conducted using keywords like "probiotics," "supplements," "ASD," "gut dysbiosis," and "therapeutic interventions." Studies meeting inclusion criteria, including clinical trials, observational studies, and case reports, were considered. Results: Several studies suggest that probiotics may improve behavior, brain activity, and eye contact in individuals with ASD by addressing gut dysbiosis. Lactobacillus reuteri and specific Bifidobacterium strains are recommended probiotics, but more research is needed to confirm their efficacy. This review also explores supplements like Vitamin B6, magnesium, Vitamin B12, Vitamin C, and Omega-3 fatty acids, which show potential in supporting speech and overall well-being in individuals with ASD. However, they are not a cure and should be used under professional guidance. The article also discusses supplements for adults with ASD, underlining the importance of consulting healthcare professionals before use and the necessity for further research to determine effectiveness and optimal dosages. Conclusion: Probiotics and supplements offer potential benefits for individuals with ASD, but they should be seen as complementary therapies rather than cures. A holistic approach, including medical supervision, therapy, and dietary considerations, is crucial for addressing the complex needs of individuals with ASD. Further research is necessary to uncover the precise mechanisms and therapeutic potential of these supplements in enhancing the lives of those with ASD. Categories: Neurology, Gastroenterology, Nutrition

Wellbeing of the older individuals in East Asia

Wellbeing of the older individuals in East Asia

Exploring the effects of time pressure and distracting elements in an Augmented Reality game for emergency preparedness

The development of emergency preparedness and response skills is crucial for ensuring individual safety and well-being during natural disasters. Realistic and engaging games can effectively promote these skills. This paper explores the impact of introducing additional game objects as distractors and time pressure on user experience and willingness to prepare for emergencies in an Augmented Reality (AR) game. Additional, distracting game elements and time pressure are included in the game scenario to simulate the cognitive demands and stress experienced in real emergency situations. To investigate the impact of distracting game elements and time pressure, a within-subjects study was conducted with 52 participants who played two different versions of an AR game designed to help locate recommended items for an emergency grab bag. In the first version, participants focused solely on finding the recommended items, while in the second version, distractors and a timer were introduced to emphasize the urgency of packing the bag. The results showed no significant difference in user experience between the two versions. However, the version with time pressure and distractors demonstrated a significant improvement in attitudes and perceived behavioral control regarding immediate actions in response to evacuation warnings. Qualitative feedback from participants supported these effects. These findings suggest new directions for further research and highlight the potential of AR games to enhance emergency response strategies.

Unlocking proactive socialization dynamics: investigating work engagement through social capital resources, the interplay of proactive personality and perceived organizational support

PurposeThis study aims to explore the relationship between proactive socialization behaviors (PSBs) and work engagement, with a specific focus on the mediating role of social capital resources (SCRs). Additionally, it investigates how proactive personality and perceived organizational support (POS) moderate the organizational assimilation of newcomers in Punjab, Pakistan, through the lens of self-determination theory.Design/methodology/approachA cross-sectional survey design was employed, with data collected from diverse organizations across cities in Punjab, Pakistan, including Bhimber, Gujrat, Gujranwala, Lahore, Jhelum, Kharian, Kotla, Mandi Bahauddin, and Sialkot. A total of 1,000 questionnaires were distributed, resulting in 619 valid responses. The sample primarily consisted of individuals with varying levels of work experience, contributing to the diversity of the data. SEM was utilized to analyze the relationships between the studied variables.FindingsResults indicated a significant positive association between PSBs and work engagement among newcomers. SCRs were found to mediate this relationship, suggesting that proactive behaviors help newcomers accumulate social capital, which enhances work engagement. Moreover, the study reveals that proactive personality and POS significantly moderate the relationship between PSBs and work engagement, with stronger positive associations observed among proactive individuals and those perceiving higher organizational support.Practical implicationsThe study underscores the importance of encouraging proactive socialization behaviors and strengthening organizational support systems to foster newcomer engagement and facilitate successful assimilation.Social implicationsUnderstanding these dynamics can lead to the creation of more inclusive and supportive organizational environments, enhancing both individual well-being and organizational effectiveness.Originality/valueThis research offers new insights into the mechanisms through which PSBs impact work engagement, particularly through the accumulation of SCRs, and highlights the importance of proactive personality and organizational support as moderators.

An Ethnographic Study of Chinese Business Expatriates in Tanzania

This ethnographic study investigates the motivations and experiences of Chinese business expatriates in Tanzania, focusing on their life management, language proficiency, and engagement with petty corruption. Chinese expatriates’ motivation for expatriation is often pragmatic, prioritizing family-oriented well-being over individual well-being. Language proficiency is shown to mediate power dynamics and reduce information asymmetry, while petty corruption is a strategic investment to navigate bureaucracy and secure benefits, despite an imbalance in reciprocity. This study enhances our understanding of the cross-cultural experiences of Chinese expatriates in Tanzania and offers valuable insights for effective International Human Resource Management (IHRM) practices.

Assessing distributional justice around Cultural Ecosystem Services (CES) provided by urban green areas: The case of Bologna

Cultural Ecosystem Services (CES) and related flows of benefits – heavily influencing societal and individual health and wellbeing - are usually ascribed non-consumptive values. However, despite the increasing recognition of their contribution to citizens’ quality of life, the intangible nature of CES makes it difficult to quantify them and hard to be integrated in decision making and planning processes. Nevertheless, the assessment of the societal relevance of CES would largely help to improve people wellbeing and quality of life. CES depend not only on the characteristics and features of urban green areas, but also on preferences and needs of the users that interact with them and that contribute to co-produce ES related benefits and values. These diverse needs, coupled with the uneven distribution of urban green area and diverse ways of managing them in the city, could affect the way ES are produced and further exacerbate existing inequalities and disparities. This contribution investigates the case study of the city of Bologna, introducing a spatial approach based on a new and pluralistic notion of urban green area that consider sport facilities and Green Stewards activities, to assess the related CES co-production paths and distributional dimension of justice in the city. Results show a good accessibility to urban green area throughout the city of Bologna (around .70 %). Nevertheless, CES co-production paths are limited in those areas of the city with higher population vulnerability index, due to lower urban green area facilities and green stewards activities, thus highlighting areas with higher distributional and procedural injustice path.

Folk Wisdom and Traditional Knowledge: A Study of Mother and Child Healthcare Practices of Maram Nagas in India

Indigenous knowledge and healthcare practices are deeply embedded in the cultural fabric of tribal communities, influencing every aspect of life and ensuring the well-being of individuals. This paper delves into the Indigenous knowledge systems of the Maram Naga community in Manipur, India, mainly focusing on practices related to mother and child healthcare. The study is based on qualitative data gathered from 225 households across 12 Maram Naga villages through in-depth personal interviews and focus group discussions. It explains the beliefs, rituals, and other traditional cultural practices integral to the Maram Nagas in promoting the health and wellness of the mother and child in pre-natal and post-natal care.

Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice.

The co-chaperone FKBP51, encoded by FKBP5 gene, is recognized as a psychiatric risk factor for anxiety and depressive disorders due to its crucial role in the stress response. Another key modulator in stress response regulation is the corticotropin releasing hormone (CRH), which is co-expressed with FKBP51 in many stress-relevant brain-regions and cell-types. Together, they intricately influence the balance of the hypothalamic-pituitary-adrenal (HPA) axis, one of the primary stress response systems. Previous research underscores the potential moderating effects these genes have on the regulation of the stressful life events towards the vulnerability of major depressive disorder (MDD). However, the specific function of FKBP51 in CRH-expressing neurons remains largely unexplored. Here, through deep behavioral phenotyping, we reveal heightened stress effects in mice lacking FKBP51 in CRH co-expressing neurons (CRHFKBP5-/-), particularly evident in social contexts. Our findings highlight the importance of considering cell-type specificity and context in comprehending stress responses and advocate for the utilization of machine-learning-driven phenotyping of mouse models. By elucidating these intricacies, we lay down the groundwork for personalized interventions aimed at enhancing stress resilience and individual well-being.