Individuals living with HIV often experience reduced exercise tolerance due to anemia, fatigue, and muscle deconditioning, significantly impacting their quality of life. Blood transfusions emerge as a critical intervention to improve physical well-being by increasing hemoglobin levels and enhancing oxygen delivery to tissues. This review article explores the mechanisms by which blood transfusions positively influence exercise tolerance in HIV patients, highlighting the physiological benefits of improved oxygenation and energy levels, which facilitate greater participation in physical activities. In addition to the physiological benefits, enhanced exercise tolerance can lead to psychological improvements, reducing symptoms of anxiety and depression commonly faced by individuals with HIV. Engaging in physical activities fosters a sense of accomplishment and boosts self-esteem, creating a positive feedback loop that encourages a more active lifestyle. This multifaceted approach underscores the importance of integrating blood transfusion therapy into comprehensive HIV care to support both physical and mental health. Keywords: anemia, blood transfusions, exercise tolerance, HIV, physical well-being