Well-nourished Group Research Articles

The effects of nutritional status and intervention on pulmonary functions in pediatric cystic fibrosis patients

Cystic fibrosis (CF) causes malabsorption of nutrients that exacerbate pulmonary problems. Nutritional interventions can improve pulmonary functions. We aimed to evaluate the effects of nutritional intervention in CF patients with malnutrition, and to determine ifthere is a correlation between nutritional status and pulmonary functions. The study included 143 CF patients (67 females) with a mean 2year follow-up time. Patients' sociodemographic data, presenting symptoms and history were recorded. Height-for-age, weight-for-age, weight-for-length/height (WFL/H), and body mass index (BMI) were calculated in all patients. Patients were grouped as well nourished, mild malnutrition, moderate malnutrition, and severe malnutrition. These four groups were compared in terms of pulmonary function test results, lung infections, and the hospitalization rate. Among the patients with a WFL/H or BMI z-scores that decreased, the frequency of lung infection was 74.1% and the hospitalization rate was 40.7%, versus 34% and 12.3%, respectively among the patients with a WFL/H or BMI z-scores that increased. The difference was significant (P=0.02 and P=0.01, respectively). The difference in bacterial lung infections differed significantly between the four nutritional status groups (P=0.002). Patients in the well-nourished group had significantly higher pulmonary function test scores than the other groups. The forced expiratory volume in the first second differed significantly between the patients with and without an increase in the WFL/H or BMI z-scores (P=0.001). The appropriate nutritional intervention to pediatric CF patients with malnutrition, decrease the frequency of lung infections, and improve respiratory function.

The Influence of Dysphagia on Nutritional and Frailty Status among Community-Dwelling Older Adults.

Malnutrition is a core symptom of the frailty cycle in older adults. The purpose of this study was to investigate whether dysphagia influences nutrition or frailty status in community-dwelling older adults. The study participants were 320 Japanese community-dwelling older adults aged ≥65 years. All participants completed a questionnaire survey that included items on age, sex, family structure, self-rated health, nutritional and frailty status, and swallowing function. Nutritional status was categorized as malnourished, at risk of malnutrition, and well-nourished based on the Mini Nutrition Assessment-Short Form. The participants were then classified into a malnutrition (malnourished/at risk) or a well-nourished group (well-nourished). Frailty was assessed using the Cardiovascular Health Study criteria. The participants were then divided into a frailty (frail/pre-frail) or a non-frailty group (robust). Dysphagia was screened using the 10-item Eating Assessment Tool. Multiple logistic regression analysis was conducted to determine whether dysphagia was associated with nutritional or frailty status. The results revealed that dysphagia influenced both nutrition (odds ratio [OR]: 4.0; 95% confidence interval [CI]: 1.9–8.2) and frailty status (OR: 2.3; 95% CI: 1.0–5.2); therefore, the swallowing function would be an important factor for community-dwelling older adults on frailty prevention programs.

Relationship of Malnutrition in Children with Food and Nutrition Insecurity in Fars Province, Iran

Background: Because of the high prevalence and serious complications of malnutrition in children, in this study, we aimed to evaluate the association of malnutrition in children with food and nutrition insecurity in Fars Province, Iran. Methods: In this case-control study, all 6 - 60-month-old children living in Fars Province in 2015 and their weight for age cures were below the third percentile, were included as the malnourished group (case group). Also, 1000 sex- and age-matched children without any growth retardations were selected as the well-nourished group (control group). The children’s food and nutrition insecurity was evaluated using a questionnaire consisting of the child's feeding, household sanitation status, and food security, besides maternal knowledge and practice about child nutrition. Finally, the food insecurity status of the two groups was compared. Results: Based on the findings, 943 (47.1%) children lived in food-insecure households, with a higher percentage of malnourished children than well-nourished ones (57.8% vs. 36.5%; P < 0.001). The probability of malnutrition in the children with full time working fathers was half of those with unemployed fathers (OR = 0.56, 95% CI: 0.38 - 0.83). Malnutrition in children was significantly associated with their birth weight (P < 0.001), maternal body mass index (P < 0.001), maternal knowledge and practice about child feeding (P < 0.001 for both), and having sanitary latrines at home as an indicator of household sanitary status (P < 0.001). Conclusions: Malnutrition in children had significant associations with many aspects of food and nutrition insecurity. To decrease the prevalence of malnutrition, health systems, and other organizations should design policies to improve food insecurity, especially those focusing on family education and nutritional support for low socioeconomic families.

Is hand grip strength a necessary supportive index in the phenotypic criteria of the GLIM-based diagnosis of malnutrition in patients with cancer?

The Global Leadership Initiative on Malnutrition (GLIM) has the potential to gain global acceptance for diagnosing malnutrition. Of which, calf circumference (CC) was proposed as an alternative to evaluate the reduced muscle mass (RMM). The present study aimed to evaluate whether including the hand grip strength (HGS) was helpful for diagnosing malnutrition under the GLIM framework. We performed a multicenter, observational cohort study including 3998 patients with cancer at two teaching hospitals. The RMM criterion was separately assessed using the calf circumference (CC), or the CC and HGS combined. Accordingly, two methods of GLIM diagnosis were independently developed to determine the nutritional status of the patients. The diagnostic concordance, baseline characteristics, and outcomes of patients were compared across the malnourished-CC-HGS, malnourished-CC+HGS, and well-nourished groups. The Patient-Generated Subjective Global Assessment (PG-SGA) was used as a comparator to identify the optimal method. Malnutrition was identified in 1120 (28%) patients by the CC method and 1060 (26.5%) patients by the CC+HGS method. Compared to the well-nourished group, the malnourished-CC+HGS group (60 patients, 1.5%) had poorer nutritional characteristics, poorer Karnofsky Performance Status scores, poorer global quality of life scores, and higher Nutritional Risk Screening 2002 scores. The severity of malnutrition diagnosed using the CC method (Kappa = 0.136) showed higher agreement with the PG-SGA than the CC+HGS method (Kappa = 0.127). Compared to CC+HGS, the CC alone appears to be adequate to evaluate RMM under the GLIM framework. A simpler method might facilitate the application of these criteria in clinical settings by increasing efficacy and minimizing missed diagnoses.

The relationship between the degree of malnutrition and changes in selected parameters of the immune response in critically ill patients.

Patients treated in intensive care units (ICUs) are at high risk of malnutrition and the resulting homeostasis, metabolic, histological and immunological disorders, especially leading to organ failure and increased susceptibility to infection. In 163 patients with malnutrition [mild in 33 (19.6%), moderate in 69 (42.9%), severe in 61 (37.4%)] treated in the ICU, changes in the concentration of selected proteins [interleukin (IL)-1Ra, tumor necrosis factor α (TNF-α), soluble tumour necrosis factor receptor-1 (sTNFR1), IL-6, IL-10, sTLR4, MyD88, A20, HSP70, HMGB1] were examined. In the whole group of malnourished patients, median values of sTNFR1, TNF-α, IL-6, TLR4, IL-1Ra were significantly increased, while the levels of MyD88 and A20 proteins were significantly reduced (in comparison to the well-nourished healthy group). Only the sTNFR1 protein showed a significant difference between mild, moderate and severe malnutrition, and increased concentrations as the severity of malnutrition increased (the correlation study found that as the degree of malnutrition increased, the sTNFR1 concentrations increased; p = 0.0000, R = 0.5442). It was observed that death was significantly more frequent in the group of patients who on the first day of hospitalization in the ICU scored 5 or more points on the NRS 2002 scale (p = 0.0004). In the patients who died significantly higher concentrations of sTNFR1, IL-6, IL-10, HSP70 were observed in comparison to the patients who survived. The present results are encouraging and indicate the desirability of undertaking multicentre clinical trials including monitoring of sTNFR1 in assessing the severity of malnutrition and immune disorders in the first hours after admission to the ICU, because it can be assumed that without early diagnosis of innate immunity disorders any attempts at their modulation may be ineffective.

Factors affecting frailty among community-dwelling older adults: A multi-group path analysis according to nutritional status

BackgroundFrailty is highly prevalent in older adults. Malnutrition is a common problem in older adults and is related to frailty. ObjectivesThe aim was to investigate a structural frailty model, to verify the factors which affect the frailty of older adults, and to evaluate the moderating effects of nutritional status on frailty through multi-group analysis. DesignSecondary analysis as a descriptive survey. SamplesData were prospectively collected from 1,374 older adults (age ≥ 70) from the Korean Frailty and Aging Cohort Study in 2017. MethodsFrailty was measured by the FRAIL scale [robust (score 0), pre-frailty (score 1–2), frailty (score 3–5)], and nutritional status was evaluated by the Mini Nutritional Assessment (MNA) [well-nourished (score ≥ 24), risk of malnutrition (score 17–23.5), malnourished (score < 17)]. Other domains were evaluated with the hand grip strength test, Short Physical Performance Battery (SPPB), short form of the Geriatric Depression Scale (GDS), Mini-Mental State Examination (MMSE), and ENRICHD Social Support Instrument (ESSI). The frailty model was developed by confirming the relationship among the influencing factors of frailty. To evaluate the different frailty pathways according to nutritional status in multi-group analysis, participants were divided into two subgroups according to the mean MNA score. Subgroups were classified into a well-nourished group (n = 851) for scores equal to or higher than the average score, and a malnourished group (n = 523) for scores lower than the average score. The path analysis was performed using the AMOS 23.0 program. ResultsThe frailty model's fit indices were adequate. In the model, the most influential factor for frailty was depression, followed by SPPB, age, polypharmacy, cognitive function, and female sex. In the multi-group analysis according to nutritional status, the malnourished group significantly increased in frailty as SPPB scores decreased. In addition, SPPB scores and cognitive function significantly decreased with increasing age in the malnourished group when compared to the well-nourished group. ConclusionDepression, SPPB, age, polypharmacy, cognitive function, and female sex were found to be important factors that affect frailty. Malnourished older adults are more likely to suffer from physical impairment, lower cognitive function, and frailty. Vigorous efforts are needed to improve nutritional status in older adults, which ultimately might improve functional outcomes and frailty.

Towards identifying malnutrition among infants under 6 months: a mixed-methods study of South-Sudanese refugees in Ethiopia.

To determine (i) whether distinct groups of infants under 6 months old (U6M) were identifiable as malnourished based on anthropometric measures and if so to determine the probability of admittance to GOAL Ethiopia's Management of At Risk Mothers and Infants (MAMI) programme based on group membership; (ii) whether there were discrepancies in admission using recognised anthropometric criteria, compared with group membership and (iii) the barriers and potential solutions to identifying malnutrition within U6M. Mixed-methods approaches were used, whereby data collected by GOAL Ethiopia underwent: factor mixture modelling, χ2 analysis and logistic regression analysis. Qualitative analysis was performed through coding of key informant interviews. Data were collected in two refugee camps in Ethiopia. Key informant interviews were conducted remotely with international MAMI programmers and nutrition experts. Participants were 3444 South-Sudanese U6M and eleven key informants experienced in MAMI programming. Well-nourished and malnourished groups were identified, with notable discrepancies between group membership and MAMI programme admittance. Despite weight for age z-scores (WAZ) emerging as the most discriminant measure to identify malnutrition, admittance was most strongly associated with mid-upper arm circumference (MUAC). Misconceptions surrounding malnutrition, a dearth of evidence and issues with the current identification protocol emerged as barriers to identifying malnutrition among U6M. Our model suggests that WAZ is the most discriminating anthropometric measure for malnutrition in this population. However, the challenges of using WAZ should be weighed up against the more scalable, but potentially overly sensitive and less accurate use of MUAC among U6M.

Multi-dimensional clinical phenotyping of a national cohort of adult cystic fibrosis patients

BackgroundCystic Fibrosis (CF) is a multi-systemic disorder resulting from genetic variation in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene which can result in bronchiectasis, chronic sinusitis, pancreatic malabsorption, cholestatic liver disease and distal intestinal obstructive syndrome. This study generates multi-dimensional clinical phenotypes that capture the complexity and spectrum of the disease manifestations seen in adult CF patients using statistically robust techniques. MethodsPre-transplant clinical data from adult (age ≥18 years) CF patients (n = 992) seen in six regionally distinct US CF centers between 1/1/2014 and 6/30/2015 were included. Demographic, spirometry, nutritional, microbiological and therapy data were used to generate clusters using the Random Forests statistical-learning and Partitioning around Medoids (PAM) clustering algorithms. Five commonly measured demographic, physiological and nutritional parameters were needed to create the final phenotypes that are highly similar to a regionally matched group of patients from the CF Foundation Patient Registry ResultsThis approach identified high-risk phenotypes with expected characteristics including high rates of pancreatic insufficiency, diabetes and Pseudomonas aeruginosa colonization. It also identified unexpected populations including a) a male-dominated, well-nourished group with good lung function with a high prevalence of severe genotypes (i.e. 60% subjects had two minimal function CFTR variations), b) and an older, “survivor” phenotype that had high rates of chronic P. aeruginosa infection. ConclusionsThis study identified recognizable phenotypes that capture the clinical complexity in a statistically robust manner and which may aide in the identification of specific genetic and environmental factors responsible for these disease manifestation patterns.

Comparison of dietary intake patterns in hemodialysis patients by nutritional status: A cross-sectional analysis.

BackgroundAlthough appropriate dietary adjustments in hemodialysis (HD) patients are important, most HD patients have difficulty adhering to dietary therapy due to the stress of a restricted-food diet or loss of appetite, which eventually leads to malnutrition and other complications. The dietary intake of HD patients stratified by nutritional status has not yet been studied.MethodsIn total, 111 HD patients from five dialysis centers were stratified into 2 groups based on the Subjective Global Assessment: the well-nourished group and the poorly nourished group. The 7-day dietary intake and food behaviors of the two groups were compared. Logistic regression analysis was performed to reveal the factors associated with poorly nourished status.ResultsThe 7-day dietary survey showed a lower intake of total calories and protein and a higher intake of sodium and potassium than in the standard recommendations, but there were no differences between groups. The poorly nourished group ate fried food significantly more frequently than the well-nourished group. Moreover, higher hip and waist circumferences were significantly associated with poorly nourished status.ConclusionWe found differences in the dietary intake patterns and food behaviors between well- and poorly nourished HD patients. Further research is needed to design customized nutritional education, consultations, and dietary management for HD patients.

Impact of Tongue Pressure and Peak Expiratory Flow Rate on Nutritional Status of Older Residents of Nursing Homes in Japan: A Cross-Sectional Study.

Swallowing function is critical for continuing oral feeding to prevent frailty in older adults. In this study, we investigated the impact of tongue pressure and pulmonary function on the nutritional status of older adults. This cross-sectional study was conducted in Kitakyushu, Japan from August 2017 to November 2018. Fifty-two residents aged >65 years of age from three nursing care insurance facilities in Kitakyushu City, Japan were recruited. Oral health status, swallowing function, nutritional status using a mini nutritional assessment short form (MNA-SF), cognitive function, activities of daily living, peak expiratory flow rate (PEFR) for pulmonary function, and tongue pressure were assessed. The associations between nutritional status and the above factors were analysed using a logistic regression model. Participants were divided into two groups: well-nourished group (MNA-SF ≤12) and undernutrition group (MNA-SF <12). Multivariate logistic regression analysis revealed that the correlations of PEFR [odds ratio (OR) = 0.23, 95% confidence interval (CI) = 0.23-0.89 p=0.033) and tongue pressure (OR = 0.88, 95% CI = 0.88-0.99, p=0.029) remained significant even after adjustment with possible confounders. Maximum tongue pressure and PEFR in older adults were significantly associated with their nutritional status. These findings suggest that maintaining oral and pulmonary function may be a preventive factor against a decrease in the nutritional status of older frail adults.

SAT-307 Subjective Global Assessment for Nutritional Assessment of Patients on Regular Hemodialysis at Dialysis Unit at Tanta University Hospital

Malnutrition is a major negative prognostic factor in dialysis patients. Simple and reliable estimations of nutritional status may therefore prove of particular value in the follow-up of these patients. A cross-sectional observational study assessing the nutritional status of hemodialysis patients. 100 patients aged from (18-65) on regular hemodialysis at hemodialysis unit of Tanta University Hospitals. All were subjected to history taking, physical and clinical examination, routine laboratory investigation and we used the parameters of subjective global assessment (SGA) for evaluating nutritional status of hemodialyzed patients with anthropometric measurements and laboratory parameters. 100 patient were assessed and 82 patient were categorized as group A which represent well-nourished groups and 18 patient were categorized as group B which represent malnourished groups, there was statistically significant difference as regard to BMI, BMR, Hb, TLC, s.iron, Creat, CRP, albumin, Ca, Na, lipid profile and nutritional status .and there was significant correlation between BMI and albumin, CRP, Hb, cholesterol, TG, and LDL and also there was significant correlation between BMR and CRP, cholesterol, TG, LDL and HDL. and according to multi regression analysis the independent predictors for nutritional assessment in hemodialysis patients were albumin, creatinine and hemoglobin SGA is an easy-to-use as nutritional assessment tool that allows quick identification of malnutrition in hemodialysis patients.

Low serum leptin levels are associated with malnutrition status according to malnutrition-inflammation score in patients undergoing chronic hemodialysis.

Leptin is an adipokine secreted from adipocytes that mediate lipid metabolism and inflammation. This cross-sectional study investigated the relationship between serum leptin level and nutrition status evaluated by malnutrition-inflammation score (MIS) among patients undergoing hemodialysis (HD). This study included 100 patients on HD. Nutritional status was based on MIS (malnutrition ≥7 points). Body composition, biochemistry data, and serum leptin level were evaluated. Of 100 subjects, 33 (33.0%) were categorized as having malnutrition. Compared with subjects in the well-nourished group, those in the malnutrition group had on average an older age, longer HD duration, and lower height, weight, body mass index, waist circumference, body fat mass, serum triglyceride level, and creatinine level. Serum leptin levels were also significantly lower in the malnutrition group (P < 0.001), whereas C-reactive protein (CRP) levels were higher (P = 0.002). Multivariable linear regression analysis revealed that HD duration (β = 2.06, P = 0.009), serum leptin level (β = -5.16, P < 0.001), CRP level (β = 3.33, P < 0.001), and albumin level (β = -1.95, P = 0.008) were factors independently associated with MIS. The discriminative power of serum leptin level to predict malnutrition was 0.834 (95% confidence interval: 0.747-0.901, P < 0.001). Low serum leptin level was associated with malnutrition, and serum leptin level may be a valuable marker for nutrition assessment in patients undergoing HD.

Subjective Global Assessment for Nutritional Assessment of Patients on Regular Hemodialysis at Dialysis Unit at Tanta University Hospital

AbstractBackground: Malnutrition is a major negative prognostic factor in dialysis patients. Simple and reliable estimations of nutritional status may therefore prove of particular value in the follow-up of these patients.Aim of Study: To assess the nutritional status of hemodi-alysis patients using the Subjective Global Assessment (SGA) method and to validate Subjective Global Assessment (SGA) we compared subjective global assessment with objective measurements (anthropometry, biochemical measurements).Patients and Methods: 100 patients aged from (18-65) on regular hemodialysis at Hemodialysis Unit of Tanta Uni-versity Hospitals. All were subjected to history taking, physical and clinical examination, routine laboratory investigation and we used the parameters of Subjective Global Assessment (SGA) for evaluating nutritional status of hemodialyzed patients with anthropometric measurements and laboratory parameters.Results: 100 patient were assessed and about 82 patient were categorized as Group A which represent well-nourished groups and 18 patient were categorized as Group B which represent malnourished groups, there was statistically signif-icant difference as regard to BMI, BMR, Hb, TLC, s.iron, Creat, CRP, albumin, Ca, Na, lipid profile and nutritional status. And there was significant correlation between BMI and albumin, CRP, Hb, cholesterol, TG, and LDL and also there was significant correlation between BMR and CRP, cholesterol, TG, LDL and HDL. And according to multi regression analysis the independent predictors for nutritional assessment in hemodialysis patients were albumin, creatinine and hemoglobin.Conclusion: SGA is an easy-to-use as nutritional assess-ment tool that allows quick identification of malnutrition in hemodialysis patients.

Effects of Preoperative Malnutrition on Postoperative Surgical Outcomes and Quality of Life of Elderly Patients with Periampullary Neoplasms: A Single-Center Prospective Cohort Study.

Background/AimsWe investigated the effect of preoperative malnutrition on postoperative surgical outcomes in elderly patients undergoing pancreatoduodenectomy for periampullary neoplasms.MethodsThis prospective cohort study enrolled 154 patients aged ≥65 years with periampullary neoplasms. Using the Mini Nutritional Assessment tool, patients were categorized into three groups according to their preoperative nutritional status: well-nourished (13.0%), at-risk-of-malnutrition (59.7%), and malnourished (27.3%).ResultsSignificant intergroup differences were observed in preoperative body mass index (25.6±2.4 kg/m2 [well-nourished] vs 23.4±2.6 kg/m2 [at-risk-of-malnutrition] vs 21.1±2.8 kg/m2 [malnourished], p<0.001). The overall morbidity significantly differed between the well-nourished and malnourished groups (20% vs 50.0%, p=0.024). The rates of clinically significant postoperative pancreatic fistula were significantly different among groups (p=0.035). Univariate and multivariate analyses showed that the at-risk-of-malnutrition or malnourished status (hazard ratio [HR], 3.45; p=0.037) and intraoperative blood loss (HR, 1.01; p=0.040) significantly affected the overall postoperative morbidity in elderly patients.ConclusionsBefore surgery, 87.0% of patients were classified into the at-risk-of-malnutrition or malnourished group. Compared with well-nourished patients, patients with nutritional issues showed a higher overall surgical morbidity. Improved preoperative nutritional status leads to favorable surgical outcomes in elderly patients.

Bioelectrical impedance analysis to evaluate nutritional status in hemodialysis patients

Objective To explore the value of bioelectrical impedance analysis in evaluating hemodialysis patients′ nutritional status. Methods Cross-sectional design was employed to evaluate 193 hemodialysis patients′ nutritional status in a Level 3 hospital in Zhuhai, with bioelectrical impedance analysis, modified quantitative subjective global assessment, physical and biochemical measurement. The correlation between each index and the predictive effect of bioelectrical impedance analysis on malnutrition of patients were analyzed. Results According to bioelectrical impedance analysis, hemodialysis patients′ average muscle mass was (44.06±8.84) kg, body fat rate was (19.81±8.89)%, fat free mass index was (17.70±2.45) kg/m2, presumed bone mass was (2.49±0.46) kg, and extracellular water rate was (40.54±3.75)%. The bioelectrical impedance analysis indexes were significantly correlated with most other nutritional evaluation indexes (P<0.05). The muscle mass and bone mass of the malnourished group were lower than that of the well-nourished group (P<0.01). Multivariable logistic regression analysis found that body fat rate (OR=0.94, 95%CI 0.89-0.99), fat free body mass index (OR=0.79, 95%CI 0.66-0.93) were associated with lower risk of malnutrition, age (OR=1.08, 95% CI 1.04-1.12), dialysis age (OR=1.02, 95%CI 1.01-1.04), high sensitive C reactive protein (OR=1.11, 95%CI 1.03-1.23) were associated with higher risk of malnutrition. Conclusion Bioelectrical impedance analysis is a valid measurement on evaluating maintenance hemodialysis patients′ nutritional status. There has a high prevalence of malnutrition in hemodialysis patients. The lower risk of malnutrition is associated with higher body fat rate and higher fat free mass index, and the higher risk of malnutrition is associated with older age, longer dialysis age and higher level of high sensitive C reactive protein. Key words: Electric impedance; Hemodialysis; Nutritional status

Impact of Dietary Counselling to Improve Nutritional Status of Hemodialysis Patients

Proper nutrition may reverse the malnutrition and can modulate renal function in hemodialysis patients. In majority of the dialysis units in Pakistan, nutritional advice is given by health professionals working in dialysis. We compared the impact of dietary counseling by a renal dietitian, on nutritional status with that by health professionals working in dialysis units in patients undergoing maintenance hemodialysis. Nutritional assessments were made using subjective global assessment (SGA) scale, which combines assessment of intake, physical findings, and functional status. Two hundred and seventy‑seven patients undergoing hemodialysis from two renal care units in Hayatabad Medical Complex Peshawar and Lahore Gernal Hospital Lahore Pakistan, were enrolled (138 patients in control group, 139 in experimental group). In the experimental group, patients were given repeated dietary counseling by a renal dietician, whereas control group patients were provided with the necessary nutritional information by another health professional. Detailed nutritional, biochemical, and SGA assessment were done on all of them at the beginning and completion of study after 6 months. Patients were categorized as well‑nourished (WN) (SGA = 1–14), mild to moderate malnourishment (MMM) (SGA = 15–35), and severe malnutrition (SM) (SGA = 36–49). In the present study, the overall malnutrition rate at baseline was 95.3%, and it dropped down to 91.7% after 6 months after nutritional counseling. In the experimental group, malnutrition status decreased from 97.2% to 89.8%, whereas in the control group, malnutrition situation remained same. Compared to baseline, in the control group, there was no improvement in the WN group. However, a shift has been observed from MMM group to SM group suggesting more number of patients are becoming malnourished. Contrarily, in the experimental group, an improvement of +7.2% in WN group and +14.3% in MMM group and a drop of −21.6% in severe malnourished group suggesting more number of patients gaining nutrition. The present study observed a significant improvement in nutritional status of patients who received counseling by the renal dietician. The reduction in SGA score was independent of reductions in serum creatinine and blood urea levels Keywords : Dietary Counselling, Nutritional Status, Hemodialysis Patients DOI : 10.7176/JMPB/55-16 Publication date :May 31 st 2019

Validation of the Scored Patient-Generated Subjective Global Assessment (PG-SGA) in Thai Setting and Association with Nutritional Parameters in Cancer Patients

Background:The Scored Patient-Generated Subjective Global Assessment (PG-SGA) is a multidimensional tool to assess malnutrition and risk factors. The objectives of this study are to determine the validity of the Thai version of the Scored PG-SGA (Thai PG-SGA) and examine the correlations with selected nutritional parameters. Methods:This observational analytic study included 195 cancer patients aged greater than 18 years at a university-affiliated hospital in Bangkok, Thailand. All patients were assessed for nutritional status by Thai PG-SGA in comparison to subjective global assessment (SGA). Anthropometry, body composition, and hand grip strength were evaluated. Results:According to PG-SGA global assessment categories, 39% (75) of 195 cancer patients were well nourished, 27% (53) were moderately malnourished and 34% (67) of patients were severely malnourished. Thai PG-SGA had a sensitivity of 99.1% and a specificity of 86.0% at predicting SGA classification. PG-SGA numerical scores were significantly different between well-nourished and malnourished groups (4.2 ± 2.4 Vs 16.3 ± 4.9; p < 0.001). The PG-SGA scores, nutritional status assessed by PG-SGA, and nutritional status assessed by SGA were correlated with weight, % weight loss in one month, body mass index, body fat, and hand grip strength (p < 0.001) respectively. Conclusions:Thai PG-SGA showed high sensitivity and good specificity in predicting malnutrition in Thai cancer patients. This tool demonstrated the correlations with anthropometric parameters, body composition, and muscle strength.

Effect of malnutrition on immediate outcome of childhood bacterial meningitis: a hospital based prospective cohort study in Bangladesh

Acute bacterial meningitis is an important serious illness worldwide and causing mortality and morbidity in children. In developed countries, only 5% of patients die and 15-20% develop sequel whereas in underdeveloped countries 12-50% of patients die and 25-50% of patients develop sequel. Malnutrition can make a person more susceptible to infection, and infection also contributes to malnutrition, which causes a vicious cycle. A hospital based prospective cohort study was conducted in the Pediatrics department of Mymensingh Medical College &amp; Hospital from February 2012 to February 2013 to compare immediate outcome of bacterial meningitis: in malnourished and well nourished children. Thirty (30) cases of well-nourished and 30 malnourished were enrolled by using purposive sampling. Fever, convulsion, bulged fontanel, abnormal behavior, headache and respiratory symptoms were presenting complaints in both groups and convulsion was significantly more in malnourished group. In Malnourished group, GCS on admission was &lt;13 in majority whereas among well-nourished group it was 13-15. CSF findings were similar. Most of the exposed children were anaemic. Total 12(20%) children died, 14(23%) developed major sequel, 10(17%) patients developed minor sequel. Relative risk of death was 5 fold followed by major sequel 6 fold and minor sequel 4 fold in malnourished group. Hospital stay was more in malnourished group. This study reveals that acute bacterial meningitis occurred in all ages from 1 to 12years child of both sexes and more in under five age group and in males. Fever, convulsion and sign of meningeal irritation were prominent clinical features. This study concludes that death, major and minor neurological sequel were more common in malnourished children and young age, male sex, anaemia, weight for age Z score &lt;-2SD/ BMI &lt;3rd percentile, GCS&lt; 13 were the bad prognostic factors.

Relationship between nutritional status and improved ADL in individuals with cervical spinal cord injury in a convalescent rehabilitation ward.

Retrospective cohort study. To investigate the relationship of nutritional status with improvement of activities of daily living in individuals with cervical spinal cord injury. A convalescent rehabilitation ward at the Toyama Prefectural Rehabilitation Hospital and Support Center for Children with Disabilities in Japan. This retrospective analysis investigated adults (age ≥20 years) with cervical spinal cord injury who were consecutively admitted to a convalescent rehabilitation ward between 2006 and 2015. Data of 154 patients were analyzed. Nutritional status was evaluated using the Subjective Global Assessment (SGA; 3 groups: well-nourished, suspected of being malnourished or moderately malnourished, severely malnourished) and body mass index (BMI; 3 groups: underweight, standard, and overweight and obese). The main outcome was functional independence measure (FIM) efficiency. Multiple regression analysis was performed to investigate the relationship of SGA and BMI to FIM efficiency. FIM efficiency was significantly higher in the well-nourished group based on the SGA than in the two groups with malnutrition (P = .007: 0.32 vs. 0.26 vs. 0.10). Multivariate regression analysis revealed that FIM efficiency was similar in the underweight and standard group, but was significantly higher in the overweight and obese group (P = .006: 0.20 vs. 0.21 vs. 0.31). SGA and BMI on admission may be independently associated with FIM efficiency in patients with cervical spinal cord injury.

Platinum Combination Chemotherapy Is Poorly Tolerated in Malnourished Advanced Lung Cancer Patients with Poor Performance Status

This study aimed to explore the tolerability and safety of platinum combination chemotherapy in malnourished patients with advanced non-small cell lung cancer (NSCLC) and poor performance status (PS). We retrospectively reviewed NSCLC patients with a PS of 2 who received first-line platinum combination chemotherapy at the Shizuoka Cancer Center between December 2009 and December 2014. Nutritional status was classified using the Glasgow Prognostic Score (GPS), which is an indicator of systemic inflammation and malnutrition. The malnourished group included patients with a GPS of 2, and the well-nourished group included patients with a GPS of 0–1. Among the 31 consecutive eligible patients, the malnourished group completed fewer chemotherapy cycles than the well-nourished group (median: 2 cycles vs. 4 cycles, p = 0.0091). Hematological and non-hematological toxicities were similar in both groups. The malnourished group also experienced poorer outcomes than the well-nourished group (response rate: 0% vs. 25%; median progression-free survival: 1.7 months vs. 4.9 months, p = 0.018; and median overall survival: 5.7 months vs. 8.3 months, p = 0.028). Malnutrition might decrease the tolerability and efficacy of platinum combination chemotherapy for patients with advanced NSCLC and poor PS.