In this paper, the finite-time stochastic combination synchronization of three different chaotic systems is investigated. Based on the adaptive technique and the properties of Weiner process, a novel sufficient condition is obtained to ensure combination synchronization under stochastic perturbations. Moreover, a secure communication scheme based on the adaptive combination synchronization of three different systems, i.e., the Lorenz system, Chen system, and Lü system, with uncertainties, unknown parameters, and stochastic perturbation is presented. The simulation results show the feasibility of the proposed method.