Weight Table Research Articles

Adipose Tissue Meal-Derived Fatty Acid Uptake Before and After Diet-Induced Weight Loss in Adults with Overweight and Obesity.

This study investigated whether diet-induced weight loss alters indices of in vivo postprandial fat uptake in adipose tissue (AT) and whether these changes are associated with weight regain in adults with overweight and obesity. In this randomized controlled trial, 16 (6 male) individuals (BMI: 28-35 kg/m2 ) were randomized to either a low-calorie diet (1,250 kcal/d) for 12 weeks or a very-low-calorie diet (500 kcal/d) for 5 weeks (weight loss [WL] period) followed by a 4-week weight-stable (WS) period (together, the dietary intervention [DI] period) and a 9-month follow-up period. Arteriovenous difference measurements combined with stable isotope labeling ([U-13 C] palmitate) of a mixed meal were used to determine postprandial fatty acid uptake in AT. Body weight was significantly reduced during the WL period (-8.2 ± 0.6 kg, P < 0.001), remained stable during the WS period (0.4 ± 0.3 kg, P = 0.150), and increased during follow-up (3.5 ± 0.8 kg, P = 0.001). Meal-derived in vivo fatty acid uptake dynamics across AT and expression of genes important for fatty acid uptake, storage, and release were not significantly changed during the DI period. Subcutaneous AT does not appear prone to enhanced meal-derived fatty acid uptake after weight loss, nor were fatty acid uptake dynamics detected as related to weight regain.

Prevalence and predictors of weight change post discharge from hospital: a study of the Canadian Malnutrition Task Force.

Little is known about factors associated with weight change post discharge from hospital; yet poor nutritional status in the transition from hospital to community can result in readmission. This exploratory study aimed to determine the factors associated with weight change 30 days post discharge defined as weight gain (WG; 5+ pounds), weight loss (WL; 5+pounds) or weight stable (WS). A total of 922 medical or surgical patients were recruited from 16 acute care hospitals in 8 Canadian provinces. Telephone interviews were completed with 747 (81%) participants 30 days post discharge using a standardized questionnaire that included: self-reported weight change, assessment of appetite, usage of healthcare services and supports for food-related activities of daily living. Covariates collected during hospitalization, including nutritional status at discharge evaluated by subjective global assessment (SGA), were used in logistic regressions. Among the 747 patients, 26% reported WL, 16.7% had WG and 57.2% were WS. Those with WG were: younger (odds ratio (OR) 0.77 (0.69, 0.85)), male (OR 1.71 (1.12, 2.61)), malnourished at discharge (SGA B OR 2.13 (1.36, 3.33), SGA C OR 2.76 (1.19, 6.62)), and had a good appetite based on the low OR for fair/poor appetite (OR 0.28 (0.11, 0.66)). WL was associated with being on a special diet (OR 1.45 (1.07,1.96)) and reporting fair/poor appetite (OR 2.67 (1.76, 4.07)). Weight change was relatively common with WL predominating. Several variables were identified to be predictors of WL or weight gain, with appetite being common to both. Future work to further define and confirm these associations is warranted.

Clarifying Atomic Weights: A 2016 Four-Figure Table of Standard and Conventional Atomic Weights

To indicate that atomic weights of many elements are not constants of nature, in 2009 and 2011 the Commission on Isotopic Abundances and Atomic Weights (CIAAW) of the International Union of Pure and Applied Chemistry (IUPAC) replaced single-value standard atomic weight values with atomic weight intervals for 12 elements (hydrogen, lithium, boron, carbon, nitrogen, oxygen, magnesium, silicon, sulfur, chlorine, bromine, and thallium); for example, the standard atomic weight of nitrogen became the interval [14.00643, 14.00728]. CIAAW recognized that some users of atomic weight data only need representative values for these 12 elements, such as for trade and commerce. For this purpose, CIAAW provided conventional atomic weight values, such as 14.007 for nitrogen, and these values can serve in education when a single representative value is needed, such as for molecular weight calculations. Because atomic weight values abridged to four figures are preferred by many educational users and are no longer provided ...

Adipose tissue gene expression is differentially regulated with different rates of weight loss in overweight and obese humans.

Moderate weight loss (WL) can ameliorate adverse health effects associated with obesity, reflected by an improved adipose tissue (AT) gene expression profile. However, the effect of rate of WL on the AT transcriptome is unknown. We investigated the global AT gene expression profile before and after two different rates of WL that resulted in similar total WL, and after a subsequent weight stabilization period. In this randomized controlled trial, 25 male and 28 female individuals (body mass index (BMI): 28-35 kg m-2) followed either a low-calorie diet (LCD; 1250 kcal day-1) for 12 weeks or a very-low-calorie diet (VLCD; 500 kcal day-1) for 5 weeks (WL period) and a subsequent weight stable (WS) period of 4 weeks. The WL period and WS period together is termed dietary intervention (DI) period. Abdominal subcutaneous AT biopsies were collected for microarray analysis and gene expression changes were calculated for all three periods in the LCD group, VLCD group and between diets (ΔVLCD-ΔLCD). WL was similar between groups during the WL period (LCD: -8.1±0.5 kg, VLCD: -8.9±0.4 kg, difference P=0.25). Overall, more genes were significantly regulated and changes in gene expression appeared more pronounced in the VLCD group compared with the LCD group. Gene sets related to mitochondrial function, adipogenesis and immunity/inflammation were more strongly upregulated on a VLCD compared with a LCD during the DI period (positive ΔVLCD-ΔLCD). Neuronal and olfactory-related gene sets were decreased during the WL period and DI period in the VLCD group. The rate of WL (LCD vs VLCD), with similar total WL, strongly regulates AT gene expression. Increased mitochondrial function, angiogenesis and adipogenesis on a VLCD compared with a LCD reflect potential beneficial diet-induced changes in AT, whereas differential neuronal and olfactory regulation suggest functions of these genes beyond the current paradigm.

APFELgrid : A high performance tool for parton density determinations

We present a new software package designed to reduce the computational burden of hadron collider measurements in Parton Distribution Function (PDF) fits. The APFELgrid package converts interpolated weight tables provided by APPLgrid files into a more efficient format for PDF fitting by the combination with PDF and αs evolution factors provided by APFEL. This combination significantly reduces the number of operations required to perform the calculation of hadronic observables in PDF fits and simplifies the structure of the calculation into a readily optimised scalar product. We demonstrate that our technique can lead to a substantial speed improvement when compared to existing methods without any reduction in numerical accuracy.Program SummaryProgram Title:APFELgridProgram Files doi:http://dx.doi.org/10.17632/mhwjt5nsg7.1Licensing provisions: MIT licenseProgramming language: C++Nature of problem: Fast computation of hadronic observables under the variation of parton distribution functions.Solution method: Combination of interpolated weight grids from APPLgrid files and evolution factors from APFEL into efficient FastKernel tables.External routines/libraries:APPLgrid, APFEL

The comparative study on the practical skills of Sino-US licensed doctors' practical skill examination evaluation index system

In this paper, the constitute elements of Sino-US licensed doctors' practical skill examination evaluation index system are expounded. Through comparison, the differences on the formulation basis, classification principle, test content, and ability requirements are inferred; On the basis of referring to the advanced experience and practice of the United States, and by combining the requirements of the most basic requirements of global medical education, suggestions for improving the Chinese licensed doctors' practical skill examination evaluation index system are proposed in terms of integrating the test syllabus classification, adjusting the distribution of clinical practice ability examination content, increasing the proportion of medical humanities content test, as well as establishing a scientific examination evaluation index weight table. Key words: Medical license; Practical skills examination; Evaluation index system

Fatigue remaining life estimation for remanufacturing truck crane Jib structure based on random load spectrum

AbstractFor remanufacturing truck cranes with the characteristic of single piece production, the coupling effect of multi‐physical fields and the correlation of multi‐defect modes are also faced in service. This causes that the safety of crane jib structures has great volatility and uncertainty and is difficult to be judged by fatigue test and damage test. To solve the above problems, an approach of fatigue remaining life evaluation based on random load spectrum is presented. By collecting operating cycle times corresponding to characteristic parameter values during the given time period, the small‐sample measured load spectrum is acquired. Six probability distribution models are used to fit the lifting weight sample in characteristic parameters and the optimal distribution model based on Akaike's information criterion (AIC) is obtained. With the Latin hypercube sampling (LHS) method, a random sample of lifting weight is determined within the fixed inspection cycle. In addition, combining with the rated lifting weight table of truck crane, the corresponding jib length and working range are confirmed. Through defining random values of character parameters and matched operating cycle times, a random load spectrum is gained, thus enabling the extension of measured load spectrum. Depending on the remanufacturing information database, the remanufacturing information of truck crane are retrieved to determine fatigue dangerous cross sections and critical points of jib structures. In order to reflect the variation of structure stress level, the equivalent cross sections of dangerous cross sections are constructed. The first principal stress–time history simulation model for critical points is established, and the rain‐flow counting technology is adopted to extract the two‐dimensional stress spectrum from simulation results. Using the Paris formula combined with the greatest risk principle, the fatigue residual life of jib structure is estimated. Furthermore, the fatigue remaining life evaluation system for jib structure of remanufacturing truck crane is developed for easier application of the proposed method. Finally, as an illustrative example, jib structures of ZLJ5551JQZ110V remanufacturing truck crane are provided to demonstrate the validity and feasibility of this method and system.

Estimating Wood Weight Change on Air Drying Times for Three Coniferous Species of South Korea

The purposes of this study are to calculate the green and dried weight using wood discs, to figure out weight change on air drying times, and to develop the model of wood disc weight change for Larix kaempferi, Pinus koraiensis, and Pinus densiflora. The variables affecting the weight change were investigated, and the pattern of weight change over time was figured out through linear models. When comparing the stem green weight calculated using wood discs in this study with the weight table of Korea Forest Service, the weight was not significantly different for L. kaempferi and P. koraiensis. On the other hand, in comparison of stem dried weight, the weight was significantly different in all of three species. In addition, various measurement factors were examined to figure out the relationship with weight change, and air drying times and disc diameter were found as significant independent variables. Finally, two linear models were developed to estimate air drying times of three species, fit statistics were significant for practical use.

Rank-Optimal Weighting or “How to be Best in the OECD Better Life Index?”

We present a method of rank-optimal weighting which can be used to explore the best possible position of a subject in a ranking based on a composite indicator by means of a mathematical optimization problem. As an example, we explore the dataset of the OECD Better Life Index and compute for each country a weight vector which brings it as far up in the ranking as possible with the greatest advance of the immediate rivals. The method is able to answer the question "What is the best possible rank a country can achieve with a given set of weighted indicators?" Typically, weights in composite indicators are justified normatively and not empirically. Our approach helps to give bounds on what is achievable by such normative judgments from a purely output-oriented and strongly competitive perspective. The method can serve as a basis for exact bounds in sensitivity analysis focused on ranking positions. In the OECD Better Life Index data we find that 19 out the 36 countries in the OECD Better Life Index 2014 can be brought to the top of the ranking by specific weights. We give a table of weights for each country which brings it to its highest possible position. Many countries achieve their best rank by focusing on their strong dimensions and setting the weights of many others to zero. Although setting dimensions to zero is possible in the OECD's online tool, this contradicts the idea of better life being multidimensional in essence. We discuss modifications of the optimization problem which could take this into account, e.g. by allowing only a minimal weight of one. Methods to find rank-optimal weights can be useful for various multidimensional datasets like the ones used to rank universities or employers.

Does maternal exposure during pregnancy to higher ambient temperature increase the risk of hypospadias?

The association between ambient temperature that the mother is exposed to during pregnancy and hypospadias has not been investigated by the studies, although the recent studies showed the correlation between some congenital malformations (congenital heart disease, neural tube defect, etc.) and ambient temperature. The aim was to investigate the relation between hypospadias and the ambient temperatures that the mother is exposed to during her pregnancy. The data of patients with hypospadias that had their gestational periods in Ankara and Istanbul regions, and had other urological treatments (circumcision, urinary tract infection, pyeloplasty, nephrolithotomy, etc.) between January 2000 and November 2015 were analyzed retrospectively. The ambient temperature at 8-14 weeks of gestation was investigated for each patient by reviewing the data of the General Directorate of Meteorology, since this period was risky for development of hypospadias. The data including ambient temperature that the pregnant mother was exposed to, maternal age, parity, economical status, gestational age at birth, and birth weight were compared between two groups. The retrospective nature of the study may be a potential source for selection bias. The data of 1,709 children that had hypospadias repair and 4,946 children that had other urological treatments between 2000 and 2015 were retrospectively analyzed. There were no differences between the groups for maternal age, parity, economical status, gestational age at birth, and birth weight (Table). Analysis of exposed maximum and average ambient temperatures at 8-14 weeks of gestation revealed that July and August, hot periods in summer time, were more prevalent in the hypospadias group (p=0.01). The average and maximum monthly ambient temperatures during summer increased the risk for hypospadias (OR, 1.32; 95% CI, 1.08-1.52; and OR, 1.22; 95% CI, 0.99-1.54, respectively. In this paper, we evaluated the relation between hypospadias and the ambient temperatures that the mother is exposed during her pregnancy. The results of this study indicated that the high ambient temperatures the mother and fetus are exposed to at 8-14 weeks of gestation increased the risk of hypospadias in the offspring.

Review of footnotes and annotations to the 1949–2013 tables of standard atomic weights and tables of isotopic compositions of the elements (IUPAC Technical Report)

Abstract The Commission on Isotopic Abundances and Atomic Weights uses annotations given in footnotes that are an integral part of the Tables of Standard Atomic Weights to alert users to the possibilities of quite extraordinary occurrences, as well as sources with abnormal atomic-weight values outside an otherwise acceptable range. The basic need for footnotes to the Standard Atomic Weights Table and equivalent annotations to the Table of Isotopic Compositions of the Elements arises from the necessity to provide users with information that is relevant to one or more elements, but that cannot be provided using numerical data in columns. Any desire to increase additional information conveyed by annotations to these Tables is tempered by the need to preserve a compact format and a style that can alert users, who would not be inclined to consult either the last full element-by-element review or the full text of a current Standard Atomic Weights of the Elements report. Since 1989, the footnotes of the Tables of Standard Atomic Weights and the annotations in column 5 of the Table of Isotopic Compositions of the Elements have been harmonized by use of three lowercase footnotes, “g”, “m”, and “r”, that signify geologically exceptionally specimens (“g”), modified isotopic compositions in material subjected to undisclosed or inadvertent isotopic fractionation (“m”), and the range in isotopic composition of normal terrestrial material prevents more precise atomic-weight value being given (“r”). As some elements are assigned intervals for their standard atomic-weight values (applies to 12 elements since 2009), footnotes “g” and “r” are no longer needed for these elements.

The effect of rate of weight loss on long-term weight regain in adults with overweight and obesity.

To investigate the effect of rate of weight loss, with similar total weight loss, on weight regain in individuals with overweight and obesity. Fifty-seven participants (BMI: 28-35 kg/m(2) ) underwent a dietary intervention (DI). They were randomized to a low-calorie diet (LCD; 1250 kcal/day) for 12 weeks (slow weight loss) or a very-low-calorie diet (VLCD; 500 kcal/day) for 5 weeks (rapid weight loss) (weight loss (WL) period) followed by a 4-week weight-stable (WS) period and 9 months follow-up. Body weight and body composition (BodPod) were determined at study start and after each period. Weight change was similar in both groups after WL (LCD: -8.2 kg and VLCD: -9.0 kg, P = 0.24). Weight regain after follow-up was not significantly different between groups (LCD: 4.2 kg and VLCD: 4.5 kg, P = 0.73). Percentage fat-free mass loss (%FFML) was higher in the VLCD-group compared to the LCD-group after DI (8.8% and 1.3%, respectively, P = 0.034) and was associated with weight regain during follow-up in the whole group (r = 0.325, P = 0.018). The present study showed that, with similar total weight loss, rate of weight loss did not affect weight regain. However, %FFML after DI was associated with weight regain.

A Length–Weight Relationship for Pond‐raised Hybrid Catfish Fingerlings

AbstractA length–weight relationship was developed for pond‐raised hybrid catfish fingerlings, Ictalurus punctatus × Ictalurus furcatus. A total of 4663 fish were sampled ranging from 20 to 240 mm total length. Predicted weight (g) from length (mm) is based on the equation: Y = 0.000017311X2.868474309 (r2 = 0.996) where Y is the estimated individual fish weight and X is measured total length. The predicted values generated by this model differ from, but follow the same general trends seen with channel catfish, I. punctatus, fingerlings and can be used as a baseline for the development of a length–weight table for hybrid catfish fingerling production.

Cardiothoracic ratio (CTR) measured on post-mortem computed tomography (PMCT) – Pre- and post-ventilation

Abstract The cardiothoracic ratio (CTR) is commonly used as an indicator of cardiomegaly in clinical radiology. CTR is generally calculated using measurements from chest radiographs. More recently, a number of studies have used computed tomography (CT). This has not been attempted using with post-mortem ventilation, which would more closely mimic the inspiratory breath hold phase chest radiograph used for clinical CTR. The aim of this study was to determine whether CTR can be measured on post-mortem CT (PMCT), whether it correlates with heart weight at autopsy and suggests cardiomegaly, and what effect ventilated PMCT (VPMCT) has on CTR measurements. CTR (%) was measured on PMCT scans pre and postventilation using a method designed to mimic the deep inspiration and breath hold clinical thoracic CT, and compared with heart weights measured at autopsy with cardiomegaly defined from normal heart weight tables scaled for body size and sex. Forty-two cases with both PMCT and VPMCT were consented for research. Results showed excellent measurement repeatability. VPMCT reduced heart diameter and CTR. The best CTR threshold to correlate cardiomegaly was 50% for PMCT (sensitivity and specificity (S&S)=89% and 71%) and 44% for VPMCT (S&S=79% and 71%). The heart diameter thresholds were 130 mm for PMCT (S&S=89% and 93%) and 114 mm for VPMCT (S&S=93% and 86%). Both CTR and heart diameter, using both PMCT and VPMCT, correlated well with heart weight at autopsy. However, using VPMCT and CTR did not give any advantage to measuring heart size on standard PMCT in this study.

Review of Footnotes and Annotations to the 1949–2013 Tables of Standard Atomic Weights and Tables of Isotopic Compositions of the Elements (IUPAC Technical Report)

Review of Footnotes and Annotations to the 1949–2013 Tables of Standard Atomic Weights and Tables of Isotopic Compositions of the Elements (IUPAC Technical Report)

HOW DO WE DIGITIZE THE CONCEPT OF «MORE IMPORTANT»

The problem of multi-criteria analysis is a key element in making complex decisions, retaining its relevance for over fifty years. A number of decision-making approaches and methods, allowing assumption of rationality of their results, have been proposed over the years. The main idea behind the majority of those methods is the linear convolution of partial criterions and the main difference lies in heuristic or expert methods, implicated in numerical expression of weight coefficients of the criteria. In light of this, it seems beneficial to find universal means of multi-criterion comparison of alternatives, based on a small number of natural axioms that are strictly mathematically sound and, at the same time, simple in practical application. The paper proposes an approach based on a transition from continuous space of weight coefficients of partial criterions importance towards a discreet space of behavior methods that is more natural for the decision-maker. This transition enabled a relatively simple classification of decision-making tasks and made possible to form a universal table of relative weights of partial criterions, applicable to any task of multi-criteria optimization on a set of alternatives. In addition, several new aspects of comparative analysis of multi-criteria alternatives were considered based on the analysis of the concept of “importance”. In particular, the invalidity of averaging of normalized criteria values, considered to be of equivalent importance had been shown; also, the so-called “edge effect” which consists in the constancy of the chains of relative importance coefficients of criteria that meet the same extreme fragments of the decision-making policy. A comparative analysis of the proposed method with the well-known method of analytic hierarchy, proposed by Thomas Saaty was carried out and a modification, allowing to increase the ease of use and validity of this method, was developed.

STUDY THE FREQUENCY OF NON DIABETIC AND NORMOTENSIVE STUDENTS OF UOG VISITING THE NSMC HEALTH CARE CENTRE GUJRAT, PAKISTAN

The presenting complaints made by patients were recorded. Total 303 (males, 99; females, 204) patients were included in the study. RBG were measured with glucometer, BP with sphygmomanometer and BMI was recorded, to study the distribution of patients according to their living(residence), obesity, different dietary habits, blood glucose level and blood pressure was measured. Frequency distribution characteristics of patients lodging, presenting complaints in Health Care Centre, with the assistance of Biochemistry department of NSMC, UOG. The nature and outcome of patients were assessed and tabulated accordingly. From a total of 303 patients presented to health care center during the study period having 99 males &amp; 204 females with ratio of hostelite males 30, hostelite females 36, days scholar male 69 and days scholar female 168 (Table No.1). It has been observed that different individuals came with different dietary habits, but mixed food habit was observed in 214 individuals Table No.4). There are number of individuals who were suffered from variety of complaints like (Allergy, n=14; Gastritis/Food Poisoning, n=87; UTRI/Sore throat, n=169; Flu/Body ache/Fever, n=30; Muscular Pain, n=02 and Toothache ē Headache, n=01). Eight patients were obese and eight patients were under weight (Table No.2). Three patients were presented with high blood pressure and no patient has high blood glucose level (Table No. 3).

Impacts of Nosema sp. (Microsporidia: Nosematidae) on the sugarcane borer, Diatraea saccharalis (Lepidoptera: Crambidae)

In Brazil, the sugarcane borer, Diatraea saccharalis (Fabricius, 1794) (Lepidoptera: Crambidae), is controlled with massive releases of the hymenopteran parasitoid Cotesia flavipes Cam. (Hymenoptera: Braconidae); over 3 million hectares of sugarcane are treated annually with 18 billion parasitoids. In order to meet this demand, parasitoids are produced in D. saccharalis under laboratory conditions where a Nosema sp. is reported to be an important problem in mass rearing of the host. The goals for this work were to study the pathogenicity of the Nosema sp. and the progression of the disease in the host under laboratory conditions. The average median lethal time (LT50) of Nosema sp. in first instar D. saccharalis varied from 9±0.3 to 42±2.3days at concentration of 5×105–0.5 spores/mm3 artificial diet (107–10 spores/μl). For third instar, the average of LT50 ranged from 32±0.7 to 37±0.7days at concentration of 5×105–5×102 spores/mm3 artificial diet (107–104 spores/μl in saline). The concentration necessary to cause 50% mortality (LC50) of first instar larvae was 5.6 (0.9–17.6) spores/μl and the estimated LC50 for third instar larvae was 1,200 (200–4700) spores/μl. The impacts of Nosema sp. on D. saccharalis were analyzed for first instar larvae fed 0.5 spores/mm3 artificial diet. Duration and viability of the larval and pupal stages, adult longevity, pupal weight and fertility life table were measured for offspring of mating pairs composed of infected females and uninfected males or infected males and uninfected females and compared to offspring of uninfected pairs. Nosema sp. infection resulted in adverse effects on all biological parameters measured except for the duration of the larval and pupal stages and the weight of the male pupae, which did not differ statistically between infected and uninfected groups. The intrinsic rates of growth (rm) were greater for uninfected pairs compared to pairs with either male or female infected. The growth rate of individual larvae produced by uninfected adults was 48.2% faster than of larval offspring of infected females and it was negative (−0.003) when males were infected. Our study confirms the negative impact of the Nosema sp. in mass rearing of D. saccharalis for parasitoid production but shows potential for use as a microbial control agent of the sugarcane borer.

Atomic Theory and Multiple Combining Proportions: The Search for Whole Number Ratios

SummaryJohn Dalton's atomic theory, with its postulate of compound formation through atom-to-atom combination, brought a new perspective to weight relationships in chemical reactions. A presumed one-to-one combination of atoms A and B to form a simple compound AB allowed Dalton to construct his first table of relative atomic weights from literature analyses of appropriate binary compounds. For such simple binary compounds, the atomic theory had little advantages over affinity theory as an explanation of fixed proportions by weight. For ternary compounds of the form AB2, however, atomic theory made quantitative predictions that were not deducible from affinity theory. Atomic theory required that the weight of B in the compound AB2 be exactly twice that in the compound AB. Dalton, Thomas Thomson and William Hyde Wollaston all published within a few years of each other experimental data that claimed to give the predicted results with the required accuracy. There are nonetheless several experimental barriers to obtaining the desired integral multiple proportions. In this paper I will discuss replication experiments which demonstrate that only Wollaston's results are experimentally reliable. It is likely that such replicability explains why Wollaston's experiments were so influential.

Abstract P155: Weight Gain and Insulin Sensitivity in Adults With and Without Type 1 Diabetes

People with type 1 diabetes mellitus (T1D) have reduced insulin sensitivity (IS), which partially explains their increased risk of cardiovascular disease. However, there is limited data on how weight gain alters IS in T1D, and so this study aimed to analyze the effect of weight change on IS components in T1D and non-diabetic (non-DM) adults. This study included 1133 adults (T1D=528 and non-DM n=605) with a mean ± SD age of 38 ± 9 years from the Coronary Artery Calcification in Type 1 Diabetes cohort, examined at baseline and after 6.2±0.6 years. Weight change was categorized as follows: weight loss (WL), lost &gt; 2%), weight stable (WS), within 2% of baseline, and weight gain (WG), &gt; 2%. Estimated IS (eIS) was calculated by a model derived from a clamp study (Table) at each visit. Multiple age and sex adjusted least squares means were calculated by weight change group and diabetes status, and progression of coronary artery calcium (CAC) was examined by logistic regression. There was a significant improvement in eIS in the T1D WL group, along with a greater reduction in triglycerides and insulin dose and increase in adiponectin compared to the other weight change groups (Table). There was significant increase in eIS among the non-DM WL group, along with a reduction in triglycerides, fasting glucose, HbA1c and DBP and an increase in adiponectin. For each 2% increase in weight, the odds ratio (OR) for progression of CAC was 1.23 (95% CI 1.1-1.4, p=0.002), after adjusting for age, sex, diabetes status, and baseline BMI and CAC. The odds of CAC progression were decreased by 40% (OR 0.6, 95% CI 0.5-0.8, p=0.0007) for each SD increase in eIS, adjusting for the same variables. In conclusion, over 6 years of follow-up, weight loss increased eIS and related factors in both people with and without T1D, but was not associated with improved Hba1c in T1D. Additionally, weight gain was associated with a greater risk and eIS with a lower risk for CAC progression, demonstrating the importance of avoiding weight gain in prevention of subclinical cardiovascular disease.