Weight Table Research Articles

Two-dimensional echocardiographic right heart ratios for assessment of right heart size in dogs: Reference intervals and reproducibility.

Reference intervals for simple body weight-independent measurements of right heart size and function are limited. Generate reference intervals for measurements of right heart size indexed to the long-axis aortic valve diameter (AoD) or corresponding left heart structure (right heart ratios) and describe the reproducibility of these indices. Ninety healthy adult dogs of variable body weight. Prospective study. All dogs underwent an echocardiogram performed by the same operator. Numerous linear 2-dimensional measurements of right heart size and function from different imaging planes were performed. Eight dogs underwent repeated echocardiograms by the same operator on 3 different days, and 3 different operators performed repeated echocardiograms on the same day. Reference intervals were generated using the Clinical Laboratory Standards Institute method. Reproducibility was quantitated using coefficients of variation (CVs) and reproducibility coefficients. Reference intervals for right heart ratios were generated and allow simple assessments of right heart size and function that do not require a scaling exponent or body weight table. Right heart ratios did not show clinically relevant associations with body weight. All CVs were <22.6%. In general, CVs for right heart measurements indexed to AoD were lower compared with right heart measurements indexed to the corresponding left heart structure. Reference intervals for simple body weight-independent right heart ratios are available to help detect abnormalities of right heart size and function. Reproducibility coefficients might be useful to help identify meaningful changes in right heart size during serial evaluations.

Strategi Pengembangan Produk Baitut Tamwil Muhammadiyah (BTM) dalam Meningkatkan Keunggulan Bersaing

This research aims to formulate a product development strategy that will be carried out by KSPPS BTM West Sumatra Sungai Rumbai Branch in increasing its competitive advantage. The research method used is field research using qualitative descriptive methods. Research data collection techniques are documentation, interviews and observation. The data analysis method used is SWOT analysis which uses IFE, EFE analysis, SWOT matrix, and score weight table analysis to identify and analyze factors. From the research results, the Baitul Tamwil Muhammadiyah (BTM) product development strategy at KSPPS BTM West Sumatra Sungai Rumbai Branch has an IFE matrix analysis that produces an overall score of 3.5, which means taking advantage of the advantages of the BTM cooperative and maximizing internal factors, this has been achieved. EFE matrix analysis produces an overall score of 3.15 which shows that the BTM cooperative is very responsive to external factors by taking advantage of existing opportunities. The weighted score of the SO strategy is 3.9, the WO strategy is 3.2, the ST strategy is 3.45, and the WT strategy is 2.75. Based on the weighted assessment, the SO strategy score has the highest points compared to other strategies. The weighted evaluation is based on the contribution of the strengths or weaknesses to the achievement of the company's goals, vision and mission. The higher the weight, the greater the contribution and influence on achieving the company's goals, vision and mission, where the Strength Opportunities (SO) assessment can be used as a strategy to capture and utilize strengths in order to seize as many opportunities as possible from competitors.

A new kid on the block: The stratification pattern for space‐filling, with dimension by weight tables

A new kid on the block: The stratification pattern for space‐filling, with dimension by weight tables

Evaluation of the Scenarios of Mergers and Acquisitions in Brazil

Context -Mergers and Acquisitions (M&amp;A) are strategies that seek to conquer new markets, acquire technology, increase its portfolio of customers and products. The prospective scenario methodology aims to assist companies in making corporate decisions. Purpose -Within this context, and in an unprecedented way, the research presents a model for evaluating events for the scenarios of mergers and acquisitions planned for Brazil in the period from 2017 to 2026. Method - We used a descriptive research method, with the Multi technique -Attribute Global Inference of Quality [MAGIQ] and content analysis techniques. Conclusion - The products generated from the research were the ranking table of the global weights of the sub-factor factors and the proposal of a methodology for evaluating the events in the scenarios based on a likert scale of four points in addition to a model form for evaluation and guidance for the development of scenarios.

WordBlitz: An Efficient Hard-Label Textual Adversarial Attack Method Jointly Leveraging Adversarial Transferability and Word Importance

Existing textual attacks mostly perturb keywords in sentences to generate adversarial examples by relying on the prediction confidence of victim models. In practice, attackers can only access the prediction label, meaning that the victim model can easily defend against such hard-label attacks by denying access based on the attack’s frequency. In this paper, we propose an efficient hard-label attack approach, called WordBlitz. First, based on the adversarial transferability, we train a substitute model to initialize the attack parameter set, including a candidate pool and two weight tables of keywords and candidate words. Then, adversarial examples are generated and optimized under the guidance of the two weight tables. During optimization, we design a hybrid local search algorithm with word importance to find the globally optimal solution while updating the two weight tables according to the attack results. Finally, the non-adversarial text generated during perturbation optimization is added to the training of the substitute model as data augmentation to improve the adversarial transferability. Experimental results show that WordBlitz surpasses the baseline in terms of better effectiveness, higher efficiency, and lower cost. Its efficiency is especially pronounced in scenarios with broader search spaces, and its attack success rate on a Chinese dataset is higher than on baselines.

An Accuracy Study of Personalized Recommendation System for E-commerce Based on Big Data Analysis

Abstract E-commerce, as an emerging value chain model for the global economy, has greatly promoted development, while the impact of digitalization on traditional publishing enterprises is increasingly evident. In this paper, we propose a TextRank keyword extraction algorithm based on comprehensive weights, which extracts and assigns keywords that identify user information, behavior, and product characteristics. We then output a keyword weight table for user information, user behavior, and product keywords. Finally, utilizing an optimized collaborative filtering recommendation algorithm, we establish a recommendation model between the user-commodity matrix to build an e-commerce personalized recommendation system that provides users with more accurate customized recommendations. The practical application of the designed personalized recommendation system is examined to evaluate its accuracy. The MAE of this algorithm is smaller than that of user-based (0.8915, 0.9470) or item-based (0.8873, 0.9327) collaborative filtering algorithms, indicating that the improved collaborative filtering algorithm effectively enhances system recommendation accuracy. The direct effect value of recommendation strength is 0.344, with an indirect effect value of 0.018, leading to the highest overall effect value. This study provides users with convenient and attentive services, significantly enhances user experience quality, and generates substantial profits for the e-commerce platform.

113 Effect of Birth Weight on Tissue Copper, Iron, and Zinc Concentrations in Piglets

Abstract Pigs (n = 3,990) were used in a previous study to determine if supplemental zinc fed to sows at various timepoints during gestation would reduce pre-weaning mortality. Additionally, data were analyzed to evaluate the effect of birth weight on tissue concentrations and distribution of copper (Cu), iron (Fe), and zinc (Zn) in piglets. Mixed parity sows were fed 1 of 3 diets: a control corn-soybean meal diet containing 125 ppm supplemental Zn supplied by zinc hydroxychloride, a diet consisting of the control + 141 ppm supplemental Zn as ZnSO4 (266 ppm total supplemental Zn) fed from 5 days after breeding to farrowing, or the control diet fed from breeding to farrowing + 2,715 ppm of supplemental Zn from ZnSO4 (2,840 ppm total supplemental Zn) starting on day 110 of gestation until farrowing. Two low and 2 average birth weight pigs (n = 122) were selected from 10 sows per treatment group to assess Cu, Fe, and Zn concentrations of serum and tails. Serum was collected from each pig at day 1 of age and tails were collected on day 2 of age. Liver tissue was collected from a subset of pigs (n = 65) that died naturally or were euthanized within 2 days of age. The statistical model included fixed effects of treatment and farrowing group, the random effect of their interaction, and the random effect of pig nested within sow. Serum concentrations of each trace element did not differ by birth weight (Table). Low birth weight piglets had greater concentrations of Fe (P = 0.018) and Cu (P = 0.031) in their tails than average birth weight pigs. No differences were observed in tail Zn concentration by birth weight. Notably, pigs that died naturally weighed less at birth than euthanized pigs (P &amp;lt; 0.001). Moreover, pigs that died naturally had greater hepatic Fe concentrations (P &amp;lt; 0.001) and tended to have greater liver Cu concentrations (P = 0.098) compared with euthanized pigs. The associations between tissue iron and copper concentrations and birth weight of piglets may have nutritional and pathophysiological implications and thus warrant further investigation.

Dalton’s Long Journey from Meteorology to the Chemical Atomic Theory

The purpose of this paper is to review Dalton’s contributions to science in various fields of research in relation to the first intimation of the chemical atomic theory. Early “germs” of his physical ideas may be found in the initial meteorological studies where water vapour is viewed as an “elastic fluid sui generis” diffused in the atmosphere and not as a species chemically combined with the other atmospheric gases. The next object of Dalton’s attention was atmosphere itself. He discarded affinity between atmospheric gases as a possible cause of homogeneity and, making recourse to Newtonian Principles, considered the repulsive forces among particles. Experiments on the “nitrous air test” and on the diffusion and solubility of gases were instrumental to arrive at the chemical atomic theory. The slow, laborious, and persevering work of Dalton to get the first table of atomic weights is a fascinating piece of science which may be fully appreciated by referring to his laboratory notebooks.

Strategi Bertahan Usaha Mikro Kuliner pada Era Pandemic (Covid19) Ditinjau dari Sudut Pandang Ekonomi Syariah

The general objective to be achieved in this research is to find out the strategies used by Micro Business actors in culinary deposits so that they can survive in the midst of the Pandemic from a sharia economic point of view. This research is a qualitative field research. By using primary data and secondary data. The analytical method used is a descriptive approach, namely identifying various problems faced by the culinary sector Micro Enterprises and analyzing them using SWOT/TOWS (IFE, EFE and IE) analysis, TOWS Matrix Analysis, SWOT Weight Tables. then formulate strategies to overcome them. The method of data collection in this study is by observation, interviews and documentation. The sample method uses snowball sampling. The results of the study found that in order to survive the pandemic, Micro-Entrepreneurs in the culinary sector of the city of Bukittinggi. Based on internal and external analysis, it can be found that the main strategy is the ST strategy (Strengts and Threats) with a total score of 5.35. Bukittinggi survives the pandemic era by using the ST strategy, which is to take advantage of strengths to overcome existing threats (Covid19). Meanwhile, from a sharia economic point of view, the overall strategy for implementing sharia economic principles in business is still not optimal for micro-enterprises. &#x0D; Keywords: Covid19, Strategic Management, Marketing, Micro Enterprises, Sharia Economics

Compact and ultracompact spectral imagers: technology and applications in biomedical imaging.

Spectral imaging, which includes hyperspectral and multispectral imaging, can provide images in numerous wavelength bands within and beyond the visible light spectrum. Emerging technologies that enable compact, portable spectral imaging cameras can facilitate new applications in biomedical imaging. With this review paper, researchers will (1)understand the technological trends of upcoming spectral cameras, (2)understand new specific applications that portable spectral imaging unlocked, and (3)evaluate proper spectral imaging systems for their specific applications. We performed a comprehensive literature review in three databases (Scopus, PubMed, and Web of Science). We included only fully realized systems with definable dimensions. To best accommodate many different definitions of "compact," we included a table of dimensions and weights for systems that met our definition. There is a wide variety of contributions from industry, academic, and hobbyist spaces. A variety of new engineering approaches, such as Fabry-Perot interferometers, spectrally resolved detector array (mosaic array), microelectro-mechanical systems, 3D printing, light-emitting diodes, and smartphones, were used in the construction of compact spectral imaging cameras. In bioimaging applications, these compact devices were used for in vivo and ex vivo diagnosis and surgical settings. Compact and ultracompact spectral imagers are the future of spectral imaging systems. Researchers in the bioimaging fields are building systems that are low-cost, fast in acquisition time, and mobile enough to be handheld.

Spatiotemporal heterogeneity correction in land ecosystem services and its value assessment: a case study of the Loess Plateau of China.

The considerable variation in structures and functions of different ecosystems leads to highly variable ecosystem service values (ESVs). Consequently, the accurate quantification of ESVs can better assess and reflect impacts of land use and cover changes (LUCC) on ecosystem services. In the land use simulations of this study, a CA-Markov model was chosen and nine factors affecting land use change were evaluated, followed by the construction of a multi-criteria evaluation method to simulate land use scenarios between 2025 and 2030 on the Loess Plateau. Six key ecological indicators (economy, water production, net primary plant productivity, habitat quality, accessibility, and soil conservation) were used to correct for spatiotemporal heterogeneity within the terrestrial ESV equivalent weight table for China to obtain an ESV equivalent weight factor table that is applicable to the Loess Plateau. Using the newly corrected table, ESVs for the Loess Plateau region were estimated between 1995 and 2030, and the impacts of LUCC on ESVs were analyzed. The Kappa values for the 2015 land use simulation results were 0.80 and 0.83, which were greater than 0.75, indicating that the CA-Markov model simulations were accurate. Throughout the study period, the largest increases in land use type area were for built-up areas and forest lands, with built-up areas primarily derived from conversions of cultivated lands and grasslands, and forest land increases primarily coming from conversion of grasslands. ESVs increased overall by 933.97 × 108 yuan and 312.86 × 108 yuan from 1995 to 2018 and 2018 to 2030, respectively. The three largest contributors to ecosystem services among land use types were moderate grasses, shrublands, and dense grasslands. In conclusion, ESVs for the Loess Plateau steadily increased year by year from 1995 to 2030, indicating that ecological restoration projects played major roles in improving the stability and sustainability of the region's ecosystems.

Modelling the influence of mechanical-ecohydrological feedback on the nonlinear dynamics of peatlands

Peatlands are complex systems that exhibit nonlinear dynamics due to internal and external feedback mechanisms. However, the feedback of vegetation on peat volume changes that potentially affect peatland dynamics is not well understood. Here, we analyse the consequences of coupling between plant functional types with peat stiffness on a nonequilibrium model of a peatland by developing MPeat model. In this formulation, the peat systems prefer to exist in two possible states defined by two limit cycles, one corresponding to a wet and the other to a dry attractor. These states can also coexist under the same net rainfall indicating bistability in which a crucial drying threshold leads to a tipping point and associated regime shift from soft-wet to stiff-dry states with related changes in rates of carbon storage. While the shift from wet to dry states constitutes a tipping point, to shift from the dry to wet states requires more sustained increases in net rainfall, indicating that dry state is the more stable attractor as the peatland grows. As the model peatland evolves, the response of surface motion, carbon accumulation, and water table depth to the same external forcing becomes increasingly higher amplitude indicating that a degree of caution may be required when interpreting the paleorecord. Investigation of the behaviour of these states in response to seasonal variations in water budget suggests that the wet state will display high amplitude and later peak timing when compared to the dry state, a phenomenon that is observed in measures of surface motion. Our study highlights the possible importance of mechanical-ecohydrological feedback and, in particular, the role of the coupling between the proportion of plant functional types, peat Young's modulus, plant weight, and water table position in influencing peatland regime shifts, critical thresholds or tipping points, and both short- and long-term peatland dynamical behaviour.

Abstract 13744: The Association of Pre-Pregnancy Obesity on Postpartum Blood Pressure in Preeclampsia

Background: Women with preeclampsia have elevated risk of long-term cardiovascular disease, in part mediated by postpartum hypertension. Little is known about the association of pre-pregnancy obesity with postpartum blood pressure. Hypothesis: We hypothesized that women with pre-pregnancy obesity and preeclampsia will have higher postpartum blood pressure compared to women without preeclampsia. Methods: We included women with preeclampsia followed between 2021-2022 at a tertiary care academic center. An equal number of women without preeclampsia were then included, matched for body mass index (BMI). Pre-pregnancy weight (exposure variable) was categorized according to BMI (in kg/m 2 ) at the initial antenatal visit as follows: normal weight (&lt;25), overweight (25-&lt;30), class I obesity (30-&lt;35) and class II+ obesity ( &gt; 35 kg/m 2 ). MAP from the 6 week postpartum visit was the outcome variable. Adjusted linear regression was performed for the association of BMI category with MAP, stratified by preeclampsia status. Interaction between BMI category and preeclampsia on the outcome of MAP was tested in the fully adjusted model. Results: Among 426 women, 247 had preeclampsia. Mean age was 31 + 6 and 32 + 5 years for women with and without preeclampsia, respectively. 54% of women with preeclampsia and 43% without identified as Black. Chronic hypertension was present in 30% vs 11% of women with vs without preeclampsia. Among women with preeclampsia, obesity class II/III was associated with higher postpartum MAP than normal weight (Table). This association was not seen in women without preeclampsia (p-value interaction = 0.004). Conclusion: Higher pre-pregnancy BMI is associated with greater postpartum MAP in women with preeclampsia, but not in women without preeclampsia. These findings underscore the importance of reducing the burden of pre-pregnancy obesity in populations at risk for preeclampsia, to prevent long-term adverse cardiovascular outcomes after pregnancy.

Model Pengembangan Usaha Mikro Industri Pakaian Jadi (Konveksi) Pada Era Pandemic Disease (Covid-19) Di Kota Bukittinggi dalam Perspektif Ekonomi Syariah

The Covid-19 pandemic has an impact not only on the health aspect but also on the business aspect. To prevent the spread of Covid-19, the government issued a policy of limiting community activities that impacted almost all sectors of life, as well as the micro-enterprises of the city of Bukittinggi in the convection sector as one of the economic sectors affected by this pandemic. In order to survive, convection micro business actors must be able to create a development model from the strategies that have been carried out on micro business development.The main issue that the authors study in the research in this thesis is how the micro-enterprise development model in improving the economy of the City of Bukittinggi in the pandemic era and how the review from a sharia economic point of view of the strategy for the survival of micro-enterprises in improving the economy in the Covid-19 pandemic era. while the general objective to be achieved in the research is to find out the development model used by convection micro business actors so that they can survive in the midst of a pandemic from a sharia economic point of view.This research is a qualitative field research. By using primary data and secondary data. The analytical method used is a descriptive approach, namely identifying various problems faced by convection micro-enterprises and analyzing them using SWOT/TOWS (IFE and EFE) analysis. TOWS Matrix Analysis, SWOT Weight Table. then formulate strategies to overcome them. The data collection methods in this study were observation, FGD (Forum Group Discussion), interviews and documentation. The sample method uses snowball sampling.The results of the study found that the convection micro business development model during the Covid-19 pandemic in the city of Bukittinggi was based on a SWOT analysis and the strategies used were 1) utilizing e-commerce sales, 2) producing new convection products to be innovated, and 3) producing convection processed products that much needed during the Covid-19 pandemic such as masks. While from a sharia economic point of view, in general they have tried to apply sharia economic principles, but they are still not fully implemented by convection micro business actors such as honesty, responsibility and trust in payment of wages.

TSAW—a lifelong challenge or simply an unsolved mystery?

Abstract The table of standard atomic weights (TSAW) provides of the numbers included in all reprints of the periodic tables of the elements, in all textbooks in schools, high schools and universities, found on the internet, and numerous databases [1]. Whenever one needs to relate masses of an element to molar quantities, standard atomic weights come into the play. They are of fundamental importance in science, education, technology, industries, trade and commerce. It is therefore not surprising that the determination of atomic weights has a central role in chemistry. Also, it is not surprising that it needs a whole commission of experts to set-up such table with highest confidence even though at first sight it seems to be a simple compilation of numbers. That commission of experts is the Commission on Isotopic Abundances and Atomic Weights (referred to as the Commission in the text). (For more information about the Commission visit ciaaw.org).

Construction of Evaluation Index System for Training Quality of High-Level Tennis Team.

The paper established the evaluation index system of training quality of high-level tennis team, which comprising five first-class indexes: work planning evaluation index (i = 4) includes realistic state diagnosis, training goal establishment, specific training content, and training plan formulation; work implementation evaluation index (i = 4) includes training guarantee conditions, training plan implementation, training process monitoring, and training plan adjustment; work monitoring evaluation index (i = 5) includes physical function, physical fitness, sports technique, sports tactics, and sport psychology; the evaluation index of team work management (i = 2) is the team training management and team organization management; and the competition performance index (i = 2) includes the results of large-scale events and the trend of sports talents. Each index of the system was obtained by sorting analysis of radar chart. The weight table of evaluation index was calculated by analytic hierarchy process. Therefore, the evaluation index system of training quality of high-level tennis team constructed in this study aims to provide reference for real-time monitoring, comprehensive evaluation, and diagnostic evaluation of each link of high-level tennis team training.

Analysis of the Application Prospect of Computer Image Processing Technology in UI Design

In order to improve the interface experience effect of the mobile terminal software, this paper improves the UI design by combining computer image processing technology and improves the diffusion algorithm for images by improving the diffusion model, improving the diffusion coefficient and adaptively selecting the diffusion threshold. Moreover, this paper has carried out deep research on coordinate transformation and image interpolation and stored the result of coordinate transformation in the coordinate transformation table and weight table. In addition, this paper proposes an improved digital scan conversion method based on a lookup table and constructs an improved UI design system model. Through the analysis of experimental data, it can be seen that the application effect of computer image processing technology in UI design is very good, and it can effectively promote the improvement of UI design technology.

The Table of Standard Atomic Weights-An exercise in consensus.

The present Table of Standard Atomic Weights (TSAW) of the elements is perhaps one of the most familiar data sets in science. Unlike most parameters in physical science whose values and uncertainties are evaluated using the “Guide to the Expression of Uncertainty in Measurement” (GUM), the majority of standard atomic‐weight values and their uncertainties are consensus values, not GUM‐evaluated values. The Commission on Isotopic Abundances and Atomic Weights of the International Union of Pure and Applied Chemistry (IUPAC) regularly evaluates the literature for new isotopic‐abundance measurements that can lead to revised standard atomic‐weight values, Ar °(E) for element E.The Commission strives to provide utmost clarity in products it disseminates, namely the TSAW and the Table of Isotopic Compositions of the Elements (TICE). In 2016, the Commission recognized that a guideline recommending the expression of uncertainty listed in parentheses following the standard atomic‐weight value, for example, Ar °(Se) = 78.971(8), did not agree with the GUM, which suggests that this parenthetic notation be reserved to express standard uncertainty, not the expanded uncertainty used in the TSAW and TICE. In 2017, to eliminate this noncompliance with the GUM, a new format was adopted in which the uncertainty value is specified by the “±” symbol, for example, Ar°(Se) = 78.971 ± 0.008. To clarify the definition of uncertainty, a new footnote has been added to the TSAW. This footnote emphasizes that an atomic‐weight uncertainty is a consensus (decisional) uncertainty.Not only has the Commission shielded users of the TSAW and TICE from unreliable measurements that appear in the literature as a result of unduly small uncertainties, but the aim of IUPAC has been fulfilled by which any scientist, taking any natural sample from commerce or research, can expect the sample atomic weight to lie within Ar °(E) ± its uncertainty almost all of the time.

Body mass index and venetoclax-hypomethylating agent induction therapy for acute myeloid leukemia.

e19038 Background: Frontline Ven-HMA dosing is imperfectly estimated with HMA using body surface area (BSA) and Ven not BSA/weight-based. Not much is known if elevated body-mass-index (BMI) reduces drug exposure and impacts clinical outcomes with Ven-HMA. We sought to investigate the effectiveness of Ven-HMA in pts with elevated BMI and hypothesized no negative impact on outcomes. Methods: We retrospectively reviewed the records of pts with AML treated with frontline Ven-HMA from 12/2018-11/2021. The primary outcome was composite response rate (CR/CRi) as defined by 2017 ELN criteria. Pearson’s χ2 tests and Wilcoxon rank tests were used for bivariate analyses. Kaplan-Meier methods were used to calculate OS. Results: We identified 63 pts treated with frontline Ven-HMA, among whom 20 had a normal BMI (&lt;25 kg/m2), 27 were overweight (BMI 25-29 kg/m2), and 16 were obese (BMI&gt;30 kg/m2). Median age was 73 (range 37-89) and there were no differences in baseline patient- and disease-specific factors. The cohort overall was enriched for complex karyotype and TP53-mutated disease (46% and 33%, respectively), but without intergroup differences. Increasing BMI was associated with more HMA naivety and appeared to be associated with more antifungal use during induction (BMI &lt;25: 60%, BMI &gt;30: 88%; p=0.07) with similar rates of moderate/strong CYP3A4 inhibition. Early mortality (within 8-weeks of Ven-HMA), was greater in obese pts, but not significantly so (BMI&lt;25: 20%; BMI&gt;30: 31.3%; p=0.45). CR/CRi rate was similar among groups (BMI&lt;25: 40%; BMI 25-29: 52%; BMI&gt;30: 44%; p=0.71), as was ORR ( p=0.14). A sub-analysis excluding pts with prior HMA did not affect the parity in rate of CR/CRi in normal weight or obese pts (40% vs 44%, p=0.83) (Table). Conclusions: Our study showed that increasing BMI appears to have no negative influence on response to frontline Ven-HMA. However, it remains unclear whether increased BMI affects drug exposure, so dedicated studies are needed.[Table: see text]

339-OR: Oral Small-Molecule GLP-1R Agonist Danuglipron Robustly Reduces Plasma Glucose and Body Weight after Eight Weeks in Japanese Adults with Type 2 Diabetes Mellitus

Danuglipron is an oral small molecule glucagon-like peptide-1 receptor (GLP-1R) agonist shown to reduce plasma glucose and body weight after 28 days of treatment in adults with type 2 diabetes mellitus (T2DM) . This randomized, double-blind (sponsor-open) , placebo-controlled, Phase 1 study investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of danuglipron in Japanese patients with T2DM. A total of 37 patients with T2DM inadequately controlled on diet and exercise alone were randomized to twice-daily (BID) oral doses of placebo or multiple, ascending doses of danuglipron titrated to 40 mg, 80 mg, and 120 mg for 8 weeks. Multiple, oral doses of danuglipron were generally safe in Japanese participants with T2DM and resulted in approximate dose-proportional increases in exposure and significant reductions in fasting plasma glucose (FPG) , 24-hour mean daily glucose (MDG) , glycated hemoglobin (HbA1c) , and body weight (Table) . Most adverse events (AEs) were mild or moderate, with AEs of nausea, vomiting, abdominal discomfort, diarrhea, and headache reported most frequently. There were no deaths and no serious AEs related to dosing of danuglipron. No clinically significant adverse trends in labs, electrocardiogram, or vital sign abnormalities were apparent. Disclosure R.Ono: Employee; Pfizer Japan Inc. K.Furihata: Other Relationship; Eli Lilly and Company, Pfizer Japan Inc. Y.Ichikawa: Employee; Pfizer Inc., Stock/Shareholder; Pfizer Japan Inc. Y.Nakazuru: Employee; Pfizer Japan Inc., Stock/Shareholder; Pfizer Inc. A.Bergman: Employee; Pfizer Inc., Stock/Shareholder; Pfizer Inc. D.N.Gorman: Employee; Pfizer Inc. A.R.Saxena: Employee; Pfizer Inc. Funding Sponsored by Pfizer Inc.